Monash University

Evidence for endemism and local adaptation in Antarctic soil bacteria

Antarctic soils represent one of the more extreme environments for microbial life on Earth, yet they harbor heterogeneous and diverse microbial communities. Biologists have long hypothesized that Antarctic microorganisms are unique from those found on other continents due to the...

Coronary Plaque Burden and Plaque Composition in Long-Term Cancer Survivors: A Comparative CCTA Study

Abstract Background The increased risk of atherosclerotic cardiovascular disease in cancer survivors is not fully elucidated. Understanding the coronary plaque burden and composition in survivors could address this gap. Objectives To determine whether cancer survivorship is assoc...

The Impact of Intrathecal Hydrophilic Opioids on Postoperative Pain, Opioid Consumption and Adverse Events for Abdominal Surgery: A Systematic Review and Meta-analysis

Abstract Purpose of Review Intrathecal morphine (ITM) is a promising analgesic option for major abdominal surgery, but its clinical efficacy, potential adverse events and optimal dosing require further investigation. Methods We searched MEDLINE, Embase, and Cochrane Central Regis...

The indirect effects of cognitive function in the association between stroke and quality of life among older adults in a rural community: A cross-sectional study

Abstract Purpose We examined whether cognitive function statistically accounted for associations between stroke and quality of life (QOL). Methods A cross-sectional survey included adults aged ≥ 60 years in Segamat, Malaysia. Cognition was assessed using the Identification and In...

Reframing HRM for a multipolar world: insights from the Asia-Pacific region

Purpose The purpose of this anthology is to critically evaluate the role of human resource management in International Business within an increasingly multipolar, digitally disrupted and institutionally diverse global environment. By bringing together leading scholars, the collec...

Advanced Materials for Biologics Delivery to Brain Tumors

ABSTRACT Brain cancer remains a major global health challenge due to its high morbidity and mortality. Current standard therapies are often limited by incomplete tumor resection, systemic toxicity, and the inability to effectively penetrate the blood‐brain barrier (BBB), which re...

Building effective leadership and coordination for assistive technology: best practices and recommendations from six countries across Sub-Saharan Africa

BACKGROUND: Effective leadership and coordination are essential for improving access to assistive technology (AT), particularly in low- and middle-income countries where efforts are often fragmented and resources limited, posing significant challenges. This study examines best pr...

From mass-loss histories to lightcurves: a generalised framework for interaction-powered transients

Abstract We introduce a fast (~1–50 ms) and generalised public framework for modelling interaction-powered transients. The framework solves the thin-shell equations of motion for ejecta colliding with circumstellar material (CSM), and supports arbitrary CSM density and velocity p...

Stable tissue oxygen cerebral perfusion pressure (stoCPP): Proof of concept for a novel method for the assessment of optimum cerebral perfusion pressure in severe traumatic brain injury

Abstract To demonstrate a method for the identification of safe cerebral perfusion pressure (CPP) in patients with severe traumatic brain injury using brain tissue oxygen (PbtO₂) readings as a surrogate marker of cerebral blood flow. Retrospective analysis of prospectively collec...

Progress and challenges in expanding access to clinical trials in pancreatic cancer

Clinical trials are essential for developing new cancer treatments and improving patient care. However, participation remains low across oncology and is particularly challenging for people with pancreatic cancer, who often experience rapid disease progression, limited treatment o...

Beyond Behaviour: Exploring How Positive Behaviour Support Might Work for Autistic Children Within Australia's NDIS

ABSTRACT Positive Behaviour Support (PBS) is the National Disability Insurance Scheme (NDIS) endorsed‐behavioural intervention framework. Understanding how and why PBS is effective is critical, given the increasing number of autistic children accessing the NDIS. Guided by critica...

Crucial role of telomere maintenance-related genes in survival prediction and subtype identification in colorectal cancer

Abstract Telomere maintenance genes are closely related to colorectal cancer (CRC) development and progression. However, the potential influence of telomere maintenance-related genes (TMRGs) on the prognosis of CRC and their clinical relevance remains insufficiently explored. Uti...

LLM-Driven Cost-Effective Requirements Change Impact Analysis

Requirements are inherently subject to change throughout the software development lifecycle. Within the limited budget available to requirements engineers, manually identifying the impact of such changes on other requirements is error-prone and effort-intensive, especially in reg...

Customer-level factors associated with discretionary food and beverage purchasing in Aboriginal and Torres Strait Islander community stores in remote Australia: a customer intercept survey of Healthy Stores 2020

Abstract Background Healthy Stores 2020 (HS2020), a 12-week randomised controlled trial conducted in partnership with an Aboriginal-owned retail organisation, reduced retailer merchandising and store-level purchases of unhealthy foods. Evidence on the influence of customer-level...

HITH4HIPs: a feasibility trial of hospital in the home after hip fracture

In Australia, as in many other jurisdictions, people with low-trauma hip fractures often stay in hospital for extended periods, even when medically stable, increasing risk of hospital-related complications and increasing healthcare costs. In this context, we sought to determine t...

The association between documented right ventricular dysfunction and in-hospital mortality in mechanically ventilated critically ill patients receiving a noradrenaline infusion: A retrospective observational cohort study

Objective To determine the documentation of right ventricular dysfunction (RVD) in mechanically ventilated patients receiving a noradrenaline infusion, and to assess the association with in-hospital mortality, length of stay (LOS) and treatment intensity. Design and setting This...

Feasibility and acceptability of a compassion-focused program to support staff, improve workflows and enhance the clinic environment in South African primary health clinics with low ART retention

South Africa has the largest HIV epidemic globally. Despite improvement, retention on antiretroviral therapy (ART) remains challenging. We used a positive deviance (PD) approach to develop a program called Connect designed to increase retention in HIV care by improving the staff...

The effect of augmented protein intake on nitrogen balance: A nested cohort study of the TARGET protein trial

Purpose The impact of augmenting enteral protein delivery on nitrogen balance, urea generation, and kidney function in critically ill patients remains poorly defined. This study aimed to investigate these effects in a nested cohort within the TARGET Protein trial. Methods We cond...

Thalamocortical network dynamics can explain visual impulse responses and perceptual echoes

Although temporal information is ubiquitous in natural vision, the cortex shows strong intrinsic rhythmicity. Recent electroencephalogram (EEG) studies have revealed a component of the visual impulse response function (IRF) resembling a narrow alpha-band (7–13 Hz) filter with a s...

Pre-existing systemic and nasal antibodies against avian H5 influenza A viruses vary according to childhood imprinting

Avian influenza A viruses (IAVs) pose a constant pandemic threat, with the recent 2.3.4.4b clade of the H5 subtype causing high pathogenicity and spreading across animal species and geographic locations. Understanding human pre-existing immunity to avian H5 IAV can inform on popu...