Monash University

An Enhanced Projection Pursuit Tree Classifier with Visual Methods for Assessing Algorithmic Improvements

This paper presents enhancements to the projection pursuit tree classifier and visual diagnostic methods for assessing their impact in high dimensions. The original algorithm uses linear combinations of variables in a tree structure where depth is constrained to be less than the...

Association between prior ICU admission for drug overdose and ICU readmission: A retrospective registry-based study

Objective We aimed to investigate patients discharged alive from hospital following an ICU admission for drug overdose and whether exposure of prior overdose-related ICU admission was associated with a future ICU readmission. Design, setting, participants This multicentre registr...

Anxiety and mood disorders from childhood to adulthood in very preterm and term-born individuals

BACKGROUND: Very preterm (VP) birth has been associated with higher rates of anxiety and mood disorders, but the emergence and persistence from childhood to adulthood is unknown. This study examined prevalence rates and early risk factors of these disorders in VP and term-born in...

Effect of the November 2023 Medicare Benefits Schedule PSA Testing Reform on National Utilisation, Diagnostic Activity, and Health-System Expenditure in Australia

Background/Objectives: On 1 November 2023, the Medicare Benefits Schedule (MBS) introduced major reforms to prostate-specific antigen (PSA) testing in Australia, extending the minimum re-test interval for average-risk men (item 66655) from 12 to 23 months and introducing a new an...

Impact of socioeconomic status on treatment and survival in multiple myeloma in Australia

<title>Abstract</title> Outcomes in multiple myeloma (MM) have improved significantly but remain heterogeneous. We assessed the impact of non-biological social determinants of health on treatment and survival outcomes in Australia using data from the Australian and New Zealand My...

Fibrinogen Early In Severe Trauma studY II (FEISTY II): study protocol for a randomised clinical trial of fibrinogen concentrate vs cryoprecipitate in traumatic haemorrhage in Australia and New Zealand

Haemorrhage is a leading cause of preventable death amongst severe trauma patients and is often complicated by hypofibrinogenaemia. Fibrinogen replacement can be achieved using fibrinogen concentrate (FC) or Cryoprecipitate (Cryo), but comparative evidence in traumatic haemorrhag...

Effectiveness of bitter almond (Amygdalus communis L. var. Amara) gum as a prebiotic on glycemic indices, oxidative stress, and antioxidant biomarkers in women with type 2 diabetes mellitus: a randomized, placebo-controlled trial

Type 2 diabetes mellitus (T2DM) is marked by hyperglycemia, oxidative stress, and systemic inflammation. Prebiotics, such as bitter almond gum ( Amygdalus communis L. var. amara ), have the potential to influence gut microbiota and metabolic parameters, suggesting their role as d...

Steric stabilizers inhibit or enhance enzymatic digestion depending on the internal nanostructure of lipid nanoparticles

Abstract Lipidic nanoparticles (LNPs), including liposomes and cubosomes, are widely employed drug delivery systems owing to their biocompatibility and capacity for stimuli-responsive ‘smart’ drug release. Steric stabilizers, including DSPE-PEG-2000 and Pluronic F127, are commonl...

Stellar Interpretation of Meteoritic Data and PLotting for Everyone (SIMPLE): Isotope Mixing Lines for Six Sets of Core-collapse Supernova Models

Abstract Bulk meteorites and their inclusions exhibit, for many chemical elements, isotopic variability produced by nucleosynthetic events in stars and supernovae before the formation of the Sun. While the exact astrophysical origins of these variations are still a matter of deba...

Co-designed development of a vocational education and training program for peer health and social care navigators in Australia

<title>Abstract</title> Background Peer health navigators (lay patient navigators) are increasingly used to support consumers to access and navigate health and social care systems, particularly for populations experiencing barriers to care. Despite growing evidence of their effec...

Hypothermia in the intensive care unit after surgery: a registry based retrospective cohort study

Background Hypothermia is common in patients admitted to the ICU after surgery; however, its relationship with postoperative outcomes has not been fully explored. This study investigates the association between postoperative hypothermia in the ICU and patient mortality. Methods R...

Clustered coloring of graphs excluding a subgraph and a minor

A graph coloring has bounded clustering if each monochromatic component has bounded size. Equivalently, it is a partition of the vertices into induced subgraphs with bounded size components. This paper studies clustered colorings of graphs, where the number of colors depends on a...

The Saxl hypergraph of a permutation group

Given a permutation group G ≤ Sym(Ω), a subset B of Ω is said to be a base if its pointwise stabiliser in G is trivial, and thebase size b(G) is the minimum size of a base. In the notable case b(G) = 2, Burness and Giudici define the Saxl graph of G to be the graph on Ω with base...

Bedside assistant models in robotic abdominal and pelvic surgery: a systematic review of operative efficiency, training exposure, and perioperative safety

Robotic surgery depends on effective bedside assistance, yet staffing models vary between physician and non-physician assistants. We systematically reviewed comparative evidence evaluating these models in robotic abdominal and pelvic surgery. A PRISMA compliant systematic review...

Protective role of dietary antioxidant intake on long-term effects of extreme PM2.5 exposure on respiratory health

Objective: To test whether dietary antioxidants moderated effects of PM 2.5 from coal mine fire smoke on respiratory symptoms. Methods: We conducted cross-sectional analyses of diet and respiratory symptom data from 448 members of the Hazelwood Health Study Adult cohort. Individu...

Latent profile analysis of postpartum depression symptoms and its associations with weight stigma and eating behaviors among postpartum women in China

Abstract Background Postpartum depression (PPD) represents a significant maternal health challenge with diverse symptom manifestations. Traditional analytical approaches that treat postpartum women as a homogeneous group may obscure distinct symptom patterns, limiting the develop...

The Effect of Antenatal Paracetamol on Breathing Effort of Premature Infants at Birth: A Feasibility Trial

Background: Prostaglandin E2 (PGE2) suppresses perinatal breathing. Reducing antenatal PGE2 concentrations with paracetamol could stimulate spontaneous breathing in premature infants at birth. We aimed to assess feasibility and potential effects of antenatal paracetamol. Methods:...

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

ABSTRACT CEP55, a centrosomal protein frequently overexpressed in multiple cancers, is implicated in regulation of genomic instability and PI3K/AKT pathway activation, yet its role in tumor progression and the tumor microenvironment remains incompletely defined. Here, we develope...

Ag-iPyramidSERS Enables Single-Particle Detectionof Sub-200 nm Nanoplastics in Real Samples

Abstract The detection of nanoplastics smaller than 200 nm is critical because of their potential to cross biological barriers, yet it remains a significant analytical challenge in complex environmental matrices due to weak signals and matrix interference. Here, we developed an o...

Relationship between neck weakness in motor neurone disease and respiratory function: a retrospective study

AIMS: The primary aim was to explore the relationship between neck weakness in people with motor neurone disease (MND) and their respiratory function. The secondary aim was to identify whether neck weakness can be a prognostic factor. METHODS: This was a retrospective observation...