McMaster University

Hip and groin pain in physically active adults with a focus on terminology, clinical examination and imaging: A formal ESSKA‐EHPA‐ESMA Consensus

Abstract Purpose This European Society of Sports Traumatology, Knee Surgery and Arthroscopy–European Hip Preservation Associates–European Sports Medicine Association (ESSKA‐EHPA‐ESMA) formal consensus aims to provide evidence‐ and expert opinion‐based recommendations for the term...

Effects of a Cycling‐Based Aerobic Exercise Program Versus a Resistance and Neuromuscular Exercise Program on Exercise‐Induced Hypoalgesia in Knee Osteoarthritis: A Study Protocol for a Randomized Clinical Trial

ABSTRACT Background and Purpose Exercise therapy is a core treatment for knee osteoarthritis (KOA), but the effects of different exercise modalities on endogenous pain modulation remain unclear. This trial will compare a cycling‐based aerobic exercise program with a resistance an...

Purinergic Receptor P2Y2 Regulates Neurogenesis and Functional Recovery Following Spinal Cord Injury in Zebrafish

In contrast to mammals, adult zebrafish (Danio rerio) undergo neuronal regeneration following spinal cord injury (SCI), thereby allowing successful functional recovery. The adaptive regenerative response to SCI in zebrafish includes injury-induced proliferation of ependymal radia...

Characteristics of interprofessional collaboration between physicians and chiropractors within Québec multidisciplinary clinics: a mixed-methods study

Abstract Background Physician referral rates to chiropractors remain low in Quebec, and few multidisciplinary clinics include both professions. Yet these settings represent a unique opportunity to study interprofessional collaboration in musculoskeletal care. This study aimed to...

Prevalence of burnout among practising anaesthesia providers: a systematic review

Summary Introduction Burnout is characterised by emotional exhaustion, depersonalisation and reduced personal accomplishment. Anaesthesia providers are at particular risk of experiencing burnout, with implications for workforce well‐being and patient safety. We aimed to quantify...

Understanding rhythmic behavior in infancy: Perspectives for addressing developmental, methodological, and analytical challenges

Neural sensitivity to rhythm emerges prenatally, yet observable movement synchronization to an external beat occurs later and more gradually over development. Integrating findings from developmental psychology, neuroscience, music cognition, and social interaction research, we pr...

Ex vivo cardiac simulator platforms for personalized cardiovascular diagnostics and intervention planning

Ex vivo cardiac simulators are an ideal solution to the rising burden of cardiovascular disease by leveraging native tissue to replicate patient hemodynamics with high fidelity. Their continued evolution necessitates a review of the technology’s development and analysis of simula...

j-IR-vis: Vision model for infrared spectroscopy embeddings

Infrared (IR) spectroscopy provides rich structural information, but interpreting spectra at scale remains challenging. Here, we introduce j-IR-vis, a vision model trained on IR spectra for functional-group prediction and downstream molecular characterization. Trained separately...

Cross-sectional evaluation of anthropometric measures vs MRI-measured visceral and hepatic fat in a Canadian cohort

Abstract Context Accurate assessment of excess body fat and its cardiometabolic risk is essential in clinical and epidemiologic research. Body mass index (BMI), although widely used, does not capture visceral or ectopic fat. Objective To evaluate how anthropometric measures—BMI,...

How can traditional Chinese medicine trials achieve global credibility

Abstract Traditional Chinese medicine (TCM) needs credible evidence that meets international evidence-based medicine standards to achieve global credibility and acceptance. A fundamental and crucial task is to conduct high-quality randomized controlled trials (RCTs). To achieve g...

Novel urinary biomarker panel to detect Cyclosporine-induced nephrotoxicity in kidney transplantation

Kidney transplantation is the best long-term solution for kidney failure [1]. In 2017, over 20 000 people received kidney transplants in the USA [2]. More than 90% were treated with calcineurin inhibitors (CNI), including cyclosporine. CNI inhibit calcineurin, a protein that acti...

Frameworks to identify research gaps, frame research needs, and derive research priorities from evidence syntheses:a scoping review

Objectives To identify and describe frameworks for systematically identifying research gaps from evidence syntheses, framing research needs, and establishing priorities, with emphasis on their use of GRADE (Grading of Recommendations Assessment, Development and Evaluation) certai...

The historical development of sample size estimation: from Huygens and Bernoulli to the present

This paper traces the historical development of frequentist sample size estimation from its philosophical origins to its present-day complexity. Preliminary concepts were identified by Christiaan Huygens’ work on expected value and Jacob Bernoulli’s law of large numbers , which f...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Acute viral infection accelerates neurodegeneration in a mouse model of ALS

Summary While several viral infections have been associated with amyotrophic lateral sclerosis (ALS), the mechanism(s) through which they promote disease has remained almost entirely elusive. This study investigated the impact of common, acute viral infections prior to disease on...

Living With Chronic Pain: A Narrative Inquiry Into Identity Reconfiguration Among Canadian Veterans—A Research Note

Approximately one-third of Canadian Veterans live with chronic pain, which can profoundly disrupt identity as they transition to civilian life. Little is known about how chronic pain reshapes the moral and embodied dimensions of military identity. Using narrative inquiry, semi-st...

Experimental Assessment of Postearthquake Reusability and Repairability of Controlled Rocking Masonry Walls with Replaceable Energy Dissipation Devices

Abstract Recent research on controlled rocking masonry walls has focused on self-centering mechanisms with accessible energy dissipation devices and enhanced toe protection strategies to improve seismic performance. Unlike post-tensioned rocking systems, where unbonded post-tensi...

Diffusion tensor tractography of the corpus callosum in major depressive disorder: a case-control study

Major Depressive Disorder (MDD) is a common and disabling psychiatric disorder that has been associated with alterations in white-matter microstructure, including abnormalities of the corpus callosum. This study aimed to compare the brain tracts of the corpus callosum using diffu...

Follistatin Alleviates Vascular Dysfunction by Reducing Oxidative Stress and Promoting Browning in Perivascular Adipose Tissue

BACKGROUND: Essential hypertension, characterized by vascular dysfunction, remains a leading modifiable cause of death globally. Perivascular adipose tissue (PVAT), which normally reduces vasoconstriction, becomes contractile in hypertension due to increased reactive oxygen speci...

Developmental trajectories of vigilance in childhood and adolescence: Disentangling underlying mechanisms through behavioral modeling.

Sustained attention is crucial for daily functioning, yet research on vigilance development has yielded inconsistent findings. These discrepancies arise partly from the use of tasks with different vigilance demands and from limitations in the indices of sensitivity and response c...