McMaster University

Amniotic fluid index versus maximum vertical pocket for predicting adverse perinatal outcomes in singleton term pregnancies: A retrospective cohort study

OBJECTIVE: Amniotic fluid assessment is central to antepartum fetal surveillance. Current guidelines favor the maximum vertical pocket (MVP) over the amniotic fluid index (AFI), as AFI increases oligohydramnios diagnosis and labor induction rates without improving perinatal outco...

Interactions Between Health Inequalities on the Management and Outcomes of Thoracic Aortic Disease in England: A National Cohort Study

BACKGROUND: The aim of this study was to evaluate the intersectionality between measured causes of health inequality and clinical factors that influence treatment decisions and regional variations in care and survival for people with thoracic aortic disease (TAD) in England. METH...

The Forgotten Joint Score Shows High Correlation With Established Anterior Cruciate Ligament Reconstruction Patient‐Reported Outcome Measures While Capturing Joint Awareness and Functional Recovery: A Systematic Review

PURPOSE: To systematically review and analyze the existing literature on the use of the Forgotten Joint Score-12 (FJS-12) in patients undergoing anterior cruciate ligament reconstruction (ACLR), with the aim of evaluating its effectiveness as a complementary tool to traditional p...

Sex Disparity in Enrolment to Clinical Trials for Onchocerciasis and Trachoma

To determine whether female enrolment in randomized interventional clinical trials for onchocerciasis and trachoma reflects the real-world sex distribution of disease burden, and to evaluate sex-based differences across trial characteristics. We performed a cross-sectional analys...

From Awareness to Action: Co‐Designing Culturally Safe and Equitable Rehabilitation in Canada – Protocol for the Two‐Phase Ireach Qualitative Study

ABSTRACT Background Inequities in access, engagement, and outcomes persist across outpatient rehabilitation services in Canada, disproportionately affecting Indigenous Peoples, newcomers and refugees, gender‐ and sexually‐diverse individuals, and people with lower income. Althoug...

Genetic diversity and antifungal susceptibility among ecological niche populations of Aspergillus flavus in Yaoundé, Cameroon

Aspergillus flavus is a ubiquitous fungus commonly found in a variety of ecological niches including soil, crops, the air, and humans. In humans, it is the second leading cause of invasive aspergillosis (IA) and is linked to other illnesses through contamination of agricultural p...

The RESPOND trial: protocol for a novel phase-based psychotherapy and integrated neurobiological investigation of depression following early life adversity

Exposure to early life adversity (ELA) is one of the most robust predictors of future psychiatric illness. Among individuals assigned female at birth (AFAB), ELA can alter neuroendocrine, epigenetic, and inflammatory processes in ways that increase sensitivity to reproductive hor...

Vortex-induced vibrations of a circular cylinder in unsteady freestream conditions

The transient response of an elastically-mounted rigid cylinder subjected to unsteady incoming flow conditions is experimentally examined through simultaneous displacement, force, and two-component velocity field measurements. The incoming flow was varied at two distinct freestre...

Gender, descriptive representation, and the public legitimacy of international organizations

Abstract How does descriptive representation influence citizens’ perceptions of international organizations’ (IOs) legitimacy? While past work has investigated the impact of procedural and substantive dimensions on the legitimacy of IOs, the effect of descriptive representation r...

Interventions to increase involvement of primary care clinicians in providing palliative care: A scoping review

Background: It is recognized that primary care clinicians have a critical role in ensuring access to palliative care in health systems. When primary palliative care has been examined at the system level, provision is highly variable, making the study of best practices challenging...

Incidence, Risk Factors and Management of Adverse Events in Contemporary Real‐World Care of Children with Juvenile Idiopathic Arthritis

OBJECTIVE: We describe the frequency, risk factors, severity, and management of actionable and serious adverse events (AAE and SAE) in children with newly diagnosed Juvenile Idiopathic Arthritis (JIA) in Canada. METHODS: We enrolled patients within 3 months of JIA diagnosis in th...

Respiratory Syncytial Virus–Related Hospitalizations Among Infants Receiving Nirsevimab

Importance Respiratory syncytial virus (RSV) is a leading cause of hospitalization among infants. Nirsevimab, a long-acting monoclonal antibody that protects against severe RSV, was publicly funded for all infants in the Canadian provinces of Ontario and Quebec starting in the fa...

Pharmacological Management of Opioid Use Disorder: A Systematic Review and Network Meta-Analysis: Prise en charge pharmacologique du trouble de l'usage des opiacés : revue systématique et méta-analyse en réseau

Objective To assess the comparative benefits and harms of opioid substitution and antagonist therapies (OSATs) for opioid use disorder (OUD) using a network meta-analysis (NMA) of randomized controlled trials (RCTs). Data Sources Medline, EMBASE, PubMed, PsycINFO, Web of Science,...

Evaluating the use of artificial intelligence (AI) in systematic review abstract screening: a comparative study of freely available AI-aided tools

Abstract Background Manual abstract screening in systematic reviews is a time-consuming and labour-intensive task. With the rise of artificial intelligence (AI), the number of published articles has grown substantially, adding to the workload of review studies that rely on robust...

Star cluster formation from turbulent clumps. V. Stellar clustering around massive stars

Abstract Massive stars (≥8 M⊙) are known to have high degrees of multiplicity, e.g., with about 60% in triples or higher-order multiples. Such high levels of multiplicity may arise during formation (primary multiplicity) or through dynamical processing of already formed stars in...

Stability of Intrinsic Localized Modes on the Lattice with Competing Power Nonlinearities

Abstract. We study the discrete nonlinear Schrödinger equation with competing powers [Formula: see text] satisfying [Formula: see text]. The physically relevant cases are given by [Formula: see text], [Formula: see text], and [Formula: see text]. In the anticontinuum limit, all i...

Insights into the Hospital Experiences of Patients and Caregivers Affected by Sickle Cell Disease in Ontario

Abstract Objectives Sickle Cell Disease (SCD) is a group of inherited blood disorders affecting over 6,500 people in Canada with around 3500 residing in Ontario. Despite frequent interactions with healthcare providers (HCPs), individuals with SCD face barriers such as delays, sti...

Early Emergence of Cultural Differences in Audiovisual Speech Perception

Integrating auditory and visual cues is a hallmark of human speech perception, yet adults from East Asian backgrounds show less reliance on visual speech than their Western counterparts. The origins of this cultural difference, however, remain unknown. To investigate whether this...

Crack Intensity Reduction in Fe–6.5Si Alloy by Adding Cr and Controlling the Thermal Gradient

Fe-6.5wt.%Si alloy is a promising soft magnetic material for electric motor applications owing to its high electrical resistivity and low core loss. However, the intrinsic brittleness of this alloy precludes fabrication of thin laminates using conventional rolling processes. Lase...

Laboratory Stewardship: Improving Quality of Care by Linking Clinical Outcomes to Appropriate Test Utilization in Clinical Chemistry Laboratories

Stewardship of laboratory services aims to ensure appropriate test utilization and improve patient outcomes. However, clinical chemistry initiatives have largely focused on reducing test volumes and costs rather than linking interventions to clinical outcomes. This review examine...