McMaster University

Interpersonal Predictors of Youth Internalizing Symptom Trajectories During the COVID‐19 Pandemic

INTRODUCTION: The COVID-19 pandemic disrupted youths' interpersonal relationships, posing risks for internalizing distress. Yet, evidence remains limited beyond the early pandemic waves and with changing interpersonal contexts. This study examined trajectories of youth internaliz...

Serum Glial Fibrillary Acidic Protein Dynamics, Disease Progression, and Therapy Response in Multiple Sclerosis

Importance: Capturing individual multiple sclerosis (MS) progression is difficult; few studies have evaluated glial fibrillary acidic protein (GFAP) in large longitudinal cohorts with independent validation. Objective: To investigate whether serum GFAP levels and treatment-relate...

Collaboratively building teaching resources for EDI in epidemiology and biostatistics

Abstract Objectives The objective of this workshop was to collaboratively co-create concrete, practical teaching resources that embed equity, diversity, and inclusion (EDI) concepts into epidemiology and biostatistics teaching in Canada. Methods The 3-h interactive session develo...

Efficacy, Tolerability, and Safety of Pitolisant for Residual Sleepiness in Obstructive Sleep Apnea Treated with CPAP: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

There is growing evidence on the use of pitolisant for the treatment of residual excessive daytime sleepiness (EDS) in adults with obstructive sleep apnea (OSA) treated with continuous positive airway pressure (CPAP). We conducted a systematic review and meta-analysis of randomiz...

Exploring Training Needs to Facilitate Shared Decision Making in Juvenile Idiopathic Arthritis Symptom Management and the Use of the JIA Option Map

Objectives Our team developed the JIA Option Map, a web-based patient decision aid (PDA) designed to support shared decision-making (SDM) for juvenile idiopathic arthritis (JIA) symptom management. Since training for health care providers (HCP) can enhance SDM and the use of PDAs...

The Ink Strikes Back: Tattoo-Associated Uveitis Syndrome. A 5-Case Series

Objectives Tattoo-Associated Uveitis Syndrome (TAUS) is a rare immune-mediated condition characterized by synchronous inflammation, including some cases with granulomatous involvement, of tattooed skin and ocular structures, reflecting a hypersensitivity to pigment antigens. This...

Defining Difficult-to-Treat Rheumatoid Arthritis in Routine Care: Comparative Performance of Published Criteria and Description of Early and Late D2T-RA Phenotypes

Objectives Despite advances in treat-to-target strategies, a subset of rheumatoid arthritis (RA) patients remains refractory to therapy, described as difficult-to-treat RA (D2T-RA). The European Alliance of Associations for Rheumatology (EULAR) has proposed formal criteria for D2...

Performance of the 2025 ASAS-Spartan Revised Classification Criteria for Axial Spondyloarthritis in a Canadian Multicenter Inception Cohort with Psoriasis, Uveitis, or Colitis Presenting with Undiagnosed Back Pain

Objectives To test the performance of the 2025 ASAS-SPARTAN Revised Classification Criteria for Axial Spondyloarthritis (axSpA)[1] in a multicenter inception cohort of patients with undiagnosed chronic back pain attending dermatology, ophthalmology, and gastroenterology clinics w...

Exploring Decisional Factors to Include Approaches in a Patient Decision Aid for Juvenile Idiopathic Arthritis Symptom Management

Objectives Youth with juvenile idiopathic arthritis (JIA) experience physical and mental health symptoms that negatively impact their participation in daily life activities. The JIA Option Map is a web-based patient decision aid (PDA) created to facilitate decision-making for JIA...

Beyond the Bone Marrow: Aortic Inflammation in Waldenström’s Macroglobulinemia

Background Peri-aortitis is defined by inflammation of the adventitia layer of the aortic wall that can extend into the connective tissue surrounding the aorta. Primary peri-aortitis refers to IgG4-related or primary inflammatory diseases, whereas secondary causes can be non-infl...

Identification of Clinical and Radiologic Markers of Disease Presentation in Patients with Scleroderma Related Interstitial Lung Disease (SSc-ILD) in a Cohort from Ontario, Canada

Objectives Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by vasculopathy, inflammation and fibrosis of multiple organs including the skin, lungs, heart, and GI tract.[1] Lung involvement, characterized by interstitial lung disease (SSc-ILD) and pulmon...