Massachusetts General Hospital

Integration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment

Abstract Drugs for aging-related diseases may modulate aging itself, but standard clinical trial designs cannot detect such effects. Aging clocks could close this gap, but epigenetic models often yield inconsistent, hard-to-interpret results. In contrast, proteomic clocks, by tra...

Fibroblast growth factor receptor signaling in maturing osteoblasts controls cell-matrix interactions critical for osteocyte survival

Abstract The terminal differentiation of osteoblasts into osteocytes, the most abundant cell type in cortical bone, is critical for skeletal homeostasis. Osteocyte loss is a hallmark of bone aging and fragility, yet the mechanisms regulating osteocyte formation and survival are p...

Author reply to Rothschild, Bruce (Tele‐rheumatology. The risk related to diagnostic and therapeutic decisions based on purposely incomplete, unvetted examination reports)

Disclosure Form Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Amygdala shows heterogeneous atrophy and tauopathy patterns across the AD continuum

Abstract Background Amygdala shows early vulnerability in Alzheimer’s disease (AD), although its substructures have been less studied than hippocampal subfields. Neuropathological evidence suggests that tau pathology affects amygdala subnuclei differentially, yet in vivo characte...

Oral Anticoagulants in Patients With Atrial Fibrillation and Advanced CKD Not Requiring Dialysis

Importance The net benefit of oral anticoagulants (OACs) in patients with atrial fibrillation (AF) and advanced chronic kidney disease (CKD) not receiving dialysis remains uncertain. Objective To compare the estimated effectiveness and safety of apixaban compared with warfarin an...

Prenatal maternal infection promotes maternal microchimeric cells to alter infection risk in male offspring

Summary Vertically transferred maternal cells or maternal microchimeric cells (MMCs) engraft the fetus and persist in offspring for long periods of time. How altered maternal immune states arising from infection affect MMCs and their function in offspring is poorly understood. He...

Threatened Identity: Self Psychology Informed Communication for Serious Illness Care

Serious illness threatens both the body and the self: the coherent, continuous sense of who one is, from bodily integrity to psychosocial identity. When illness disrupts identity and patients confront mortality and dependence, a range of responses may follow, including behaviors...

Impact of Omitting Observation-Status Data on Hospital Readmission Metric for Pediatric Care

OBJECTIVES: Literature from Medicare beneficiaries suggests that hospital readmission metrics limited to inpatient encounters, omitting observation-status data, may not fully capture hospital performance and affect rankings. The impact of omitting observation-status data on this...

Buying Time: T cells and Delayed HIV Rebound After Treatment Interruption

Charles R Crain, Gaurav D Gaiha, Rajesh T Gandhi; Buying Time: T cells and Delayed HIV Rebound After Treatment Interruption, The Journal of Infectious Dise

Toward continuous quality observability in medicine

Hospitals often detect complications retrospectively via error-susceptible mechanisms including self-reporting, manual abstraction, or billing codes. We propose a paradigm of continuous clinical quality observability : a background, non-interruptive layer where AI agents continuo...

Mouse bio-behavioral phenotyping using a digital homecage framework for long-timescale, high-resolution, and multi-factor data collection and analytics

Long-term monitoring of behavioral and physiological processes is essential for elucidating complex brain-based phenomena and disorders that develop over extended periods, such as chronic stress, circadian disruption, and metabolic syndromes. Though digital phenotyping is well-es...

Robust inference and correlates from genetic associations with personality

Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustne...

Estimating enteric fever seroincidence in rural western Cambodia: Findings from a population-based cross-sectional serosurvey

Background: Enteric fever, caused by Salmonella enterica serovars Typhi and Paratyphi, remains an important cause of febrile illness in low- and middle-income countries (LMIC). However, the exact burden is difficult to estimate due to limitations in diagnosis and surveillance.Met...

Elevated translocator protein in skull bone marrow is linked to human chronic pain

The skull bone marrow (SBM) is emerging as a critical hub for neuroimmune signaling, yet its role in chronic pain is unknown. Using integrated positron emission tomography/magnetic resonance imaging, here, we show that the levels of 18-kilodalton translocator protein (TSPO), a pu...

Functional Brain Network Alterations Linked to Cancer-Related Cognitive Impairment in Breast Cancer Patients

Abstract Background Life expectancy for cancer patients has improved due to new therapies, but many survivors experience long-lasting side effects, including cancer-related cognitive impairment (CRCI). CRCI symptoms—such as difficulties with attention, memory, processing speed, f...

Preoperative, Intraoperative, and Postoperative Parathyroid Pathology: Clinical Pathologic Collaboration for Optimal Patient Management.

Parathyroid disease typically presents with parathyroid hyperfunction as result of neoplasia or a consequence of non-neoplastic systemic disease. Given the parathyroid gland is a hormonally active organ with broad physiologic implications and serologically accessible markers for...

Return to Golf Rehabilitation Progression after Anterior Cruciate Ligament Reconstruction Using an Evidence-Based Foundation

Background Golf is commonly regarded as a low-impact sport, yet the golf swing generates multiplanar loads across both knees. No validated return-to-golf protocol after anterior cruciate ligament reconstruction (ACLR) has been published, and general return-to-sport timelines do n...

Remote Monitoring Devices and Heart Failure.

Remote patient monitoring (RPM) in patients with heart failure (HF) involves transmitting physiological data from devices to a health-care provider via a wireless connection with targeted interventions when values exceed the preset threshold. Devices used in telemonitoring range...

Para This, Fibromin That: The Role of CDC73 in Parathyroid Tumors and Familial Tumor Syndromes.

CDC73 alterations are associated with three main parathyroid lesions according to the World Health Organization (WHO) classification of tumors of the endocrine system. These include hyperparathyroidism-jaw tumor (HPT-JT) syndrome-associated adenomas, atypical parathyroid tumors (...

Safety of Psychotropic Medications During Pregnancy: An update on Antipsychotics, Anxiolytics & Sedative Hypnotics, Stimulants, and Medications for Treatment of Substance Use Disorders.

The objective of this article is to discuss the most updated data on the safety and efficacy of some psychotropic medications during pregnancy, specifically antipsychotic medications, anxiolytic and sedative hypnotics, stimulant medications, and medications for treatment of subst...