Massachusetts General Hospital

Safety of Psychotropic Medications During Pregnancy: An update on Antidepressants and Mood Stabilizers.

The objective of this article is to discuss the most updated data on the safety and efficacy of some psychotropic medications during pregnancy, specifically antidepressants and mood-stabilizing medications. The common disorders and the risks of not receiving treatment of certain...

Functional fractionation of large-scale brain networks in the human subcortex

Brain network mapping plays a crucial role in advancing our understanding of human brain organization and the neuroanatomic foundations of cognition. Historically, the identification of large-scale brain networks has focused on the cerebral cortex. Some cortical networks have bee...

Exploring the mediating role of working alliance in a peer support intervention for late-life depression

Objective: Peer support is an evidence-based intervention for depression, yet the mechanisms underlying its effectiveness remain understudied, particularly in randomized clinical trials. This study examined the mediating role of working alliance components (task, bond, and goal)...

Incidence, risk factors, and prognostic implications of hospitalizations for heart failure among patients with myeloproliferative neoplasms

Myeloproliferative neoplasms (MPNs), including essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF), are a group of chronic leukemias associated with increased risk of heart failure (HF). Despite a link between MPNs and HF, prognostic implications and ri...

Mapping Essential Genes in Klebsiella pneumoniae Using Transposon-Insertion Sequencing (Tn-seq)

Abstract Background Klebsiella pneumoniae is a common cause of sepsis in adults and children. Given the emergence of multidrug-resistant isolates, there is an urgent need to develop novel therapeutic strategies. Essential bacterial genes and their products, which are critical to...

Rhinosinusitis in Adults Receiving Tumor Necrosis Factor Alpha Inhibitors and Anti‐CD20 Therapy: A Scoping Review

ABSTRACT Introduction Immunomodulatory therapies, including tumor necrosis factor alpha (TNF‐α) inhibitors and anti‐CD20 agents, are often used for autoimmune, inflammatory, and neoplastic disorders. While infection risk is well recognized, their association with rhinosinusitis r...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Balancing privacy and performance: the impact of facial defacing on AI in medical imaging

Background Recent NIH Data Management and Sharing (DMS) policy updates and NIH controlled-access data security requirements have increased attention to facial anonymization and controlled-access handling of shared head imaging data. This is particularly relevant for datasets subm...

Hallux Valgus, Not Hallux Abductus Valgus: A Short Report on Historical and Anatomical Terminology

Background: This short report argues that the term “hallux abductus valgus” is anatomically inconsistent and should be replaced by “hallux valgus.” Hallux valgus describes a lateral deviation of the great toe with a medial deviation of the first metatarsal. Although the deformity...

Summary of Research: Brentuximab Vedotin and Nivolumab in Combination with Chemotherapy for Nonbulky, Early-Stage Classical Hodgkin Lymphoma

This is a summary of the original research article “Brentuximab Vedotin and Nivolumab in Combination with Chemotherapy for Nonbulky, Early-Stage Classical Hodgkin Lymphoma.” The phase 2 SGN35-027 study (NCT03646123) is a multiple-part clinical trial of brentuximab vedotin (BV), w...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...

Investigating patients’ experiences with dyspnea associated with warm autoimmune hemolytic anemia (wAIHA) and cognitive debriefing of the FACIT-Dyspnea 10-item short form: a qualitative patient interview study

Abstract Background Dyspnea is a prominent symptom in patients with warm autoimmune hemolytic anemia (wAIHA), yet its lived experience remain under-researched. Although clinically relevant, dyspnea is not routinely assessed in wAIHA trials, and no validated patient-reported outco...

Masculinity-Informed Therapeutic Discussions: Strengthening Father Engagement and Family Mental Health Systems

OBJECTIVE: Men underuse mental health services in part because of masculine norms. Few interventions focus on masculinity in therapeutic contexts, especially in low- and middle-income countries. This study analyzed transcripts from masculinity-focused therapeutic sessions with fa...

Use of Electroconvulsive Therapy for Catatonia in Down Syndrome Regression Disorder: A Systematic Review, Case Series, and Analysis

Abstract Purpose Down syndrome regression disorder (DSRD) is a condition occurring in young people with Down syndrome. It is associated with functional decline, new onset psychopathology, and increased support needs. DSRD is often associated with catatonia, for which electroconvu...

Impact of Response to Hypomethylating Agent‐Based Therapy on Survival Outcomes in the Context of Baseline Clinical‐Molecular Risk and Transplant Status in Patients With Higher‐Risk Myelodysplastic Syndromes/Neoplasms: An analysis From the International Consortium for MDS (icMDS)

Baseline IPSS-M risk, response to hypomethylating agent (HMA) therapy, and receipt of allogeneic stem cell transplant (allo-HCT) have all been individually shown to impact overall survival (OS) in patients with myelodysplastic syndromes (MDS). However, the prognostic impact of re...

Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture

Endolysosomal dysfunction is a hallmark of Alzheimer’s disease and related tauopathies, yet underlying mechanisms remain poorly understood. This study investigates the role of sphingolipid metabolism in maintaining endolysosomal membrane integrity and its impact on tau aggregatio...

Utility of Face2Gene’s DeepGestalt and D-Score applications in paediatric neurodevelopmental disorders in South Africa

Abstract Face2Gene is a clinical tool that leverages facial features to aid genetic diagnosis. The DeepGestalt application suggests potential diagnoses based on facial similarity, while the D-Score evaluates likelihood of an individual having dysmorphic features suggestive of a p...

Perceptions of surrogate decision-makers of cardiac arrest patients on engaging in research during high emotional distress

The perception that individuals in crisis experience undue psychological burden by participation in research is a barrier to including surrogate decision-makers to critically ill patients in research studies. Importantly, perceptions from those who have engaged as surrogates are...

Toward Improved Classification of Vulvar Smooth Muscle Tumors

Vulvar smooth muscle tumors have been evaluated using site-specific (1979 and 1996 Vulvar Criteria) or Uterine Criteria. We compared the performance of 3 classification systems for predicting clinical behavior in the largest series of 35 such tumors to date. Follow-up was availab...

The Costs of Parkinson's Disease in Europe: Results of the Costs of Illness in Neurology Initiative

Abstract Background Parkinson's disease (PD) is the second most common neurodegenerative disease. It imposes substantial and growing burden on patients, families, and caregivers and reduces quality of life. The disability and care needs associated with PD carry economic ramificat...