Massachusetts General Hospital

Rural-Urban Disparities in Contemporary Systemic Therapy for Advanced Prostate Cancer

This cross-sectional study examines the associations of rural-urban residence and race with receipt of systemic therapy for advanced prostate cancer.

Asthma Exacerbation Risk and School Asthma Readiness

OBJECTIVES: School-based asthma management is a key facet of child asthma care. We aimed to describe the proportion of students whose schools have child-specific components of asthma care, derive a composite metric of these components ("school asthma readiness"), and assess its a...

Modeling effective doses of therapeutic antibodies targeting clustered surface receptors

Abstract A longstanding practice for therapeutic dosing of monoclonal antibodies is to identify the maximally tolerated dose. However, this approach has encountered limited success with some antibodies, especially in failed cancer trials. Here we report on an alternative dose-fin...

Deletion of the Salmonella pathogenicity island 2 gene, spiC , in attenuated Salmonella Typhimurium VNP20009 optimizes its potential for bacterial schwannoma therapy

ABSTRACT Recent advances in systems biology and immunotherapy have spurred the use of bacteria as therapeutic vehicles for cancer treatment. Currently, Bacillus Calmette–Guérin remains the only FDA-approved bacterial strain for high-risk, non–muscle-invasive bladder cancer. Altho...

Durability of wrist denervation for osteoarthritis: a multicentre outcome study

INTRODUCTION: Traditional surgical treatments for wrist osteoarthritis, such as arthrodesis or arthroplasty, are invasive and irreversibly compromise joint motion. Wrist denervation offers a less invasive alternative aimed at pain relief while preserving mobility. However, its du...

Associations between metabolic dysfunction–associated steatotic liver disease and physical and mental health–related quality of life in older adults

Metabolic dysfunction–associated steatotic liver disease (MASLD) is a common, often overlooked liver condition. Its impact on quality-of-life in older adults is not well understood. We examined the association between MASLD and physical and mental quality of life in a well-charac...

Osteochondral Autograft Options for Reconstruction of Intra-articular Distal Humerus and Proximal Ulna Injuries in Physiologically Young Patients

Purpose Surgical options are limited for distal humerus and proximal ulna injuries with articular bone loss in physiologically young patients. Osteochondral grafts are a potential treatment option between open reduction internal fixation and arthroplasty that does not impart life...

Enabling Functional Independence: A Scoping Review of Upper Extremity Assistive Devices for Adults With Progressive Neuromuscular Diseases

BACKGROUND: Assistive technology offers an important means of compensating for lost upper extremity function in adults with progressive neuromuscular diseases (NMD), enabling participation in daily activities, supporting independence, and promoting quality of life. However, the r...

Conservation of Long G4-rich (LG4) genomic enhancer regulations

Long G4-rich regions (LG4s) are defined as DNA sequences containing a high density of guanine triplets capable of forming non-B DNA structures called G-quadruplexes (G4s). These regions frequently overlap with enhancers, which are regulatory DNA elements that modulate gene expres...

Analysis of serum NMR metabolomics in fibrotic diseases of the myocardium

INTRODUCTION: Heart failure accounts for more than 43% of annual deaths worldwide, and isdriven by widespread pathological remodeling, in which myocardial fibrosis plays an important role. Currently, accurate clinical diagnosis of myocardialfibrosis (MF) remains difficult, with e...

Hyperpolarized [2– 13 C]Pyruvate Identifies a Mitochondria‐Active Hepatocellular Carcinoma Phenotype With Vulnerability to Mitochondrial Inhibition

ABSTRACT Hepatocellular carcinoma (HCC) exhibits metabolic heterogeneity that is not fully characterized by glycolysis‐focused spectroscopic profiling. This study investigated whether in vitro hyperpolarized (HP) [2‐ 13 C]pyruvate NMR spectroscopy can identify a mitochondria‐acti...

The Financial Burden of Amyotrophic Lateral Sclerosis Diagnosis: Estimating Costs of Unnecessary Procedural Interventions and Exclusionary Testing

Background: People living with amyotrophic lateral sclerosis (ALS) experience diagnostic delays, involving multiple visits to neurologists and non-neurologist specialists. During this process, patients may be misdiagnosed and undergo unnecessary procedures. Additionally, ALS diag...

Fecal microbiome transplant in food allergy in humans and mice identifies a role for bile acid metabolites in oral tolerance

The gut microbiome has been implicated in the pathogenesis of food allergy (FA), prompting microbiome-focused interventions. We evaluated, in a phase 1 open-label trial (NCT02960074), the safety and efficacy of oral encapsulated fecal microbiome transplantation (FMT) in 15 adults...

Cost-Effectiveness of Endovascular vs Open Surgery for Chronic Limb-Threatening Ischemia

Importance: Choosing between endovascular and open (bypass) surgical revascularization for chronic limb-threatening ischemia has major implications for clinical practice. Objective: To evaluate the cost-effectiveness of endovascular vs bypass surgical revascularization. Design, S...

Pulsed Field Versus Cryoballoon Ablation for Atrial Fibrillation: A Systematic Review and Meta-Analysis

In the treatment of atrial fibrillation (AF), cryoballoon ablation (CBA) is associated with a high incidence of pulmonary vein reconnection, potentially limiting long-term efficacy. Pulsed field ablation (PFA) has emerged as a promising alternative with the potential for improved...

Neddylation of NFATc1 and Runx2 regulates osteoclast–osteoblast balance and represents a dual-action therapeutic target for postmenopausal osteoporosis

Postmenopausal osteoporosis (PMOP) arises from a bone remodeling imbalance in which osteoclast-mediated resorption exceeds osteoblast-driven formation. However, current therapies primarily target osteoclasts without restoring osteoblast function, underscoring the need for mechani...

A Gap Analysis of Deep Brain Stimulation for Childhood‐Onset Movement Disorders

BACKGROUND: Deep brain stimulation (DBS) is an established and increasingly utilized therapy for childhood-onset movement disorders. However, pediatric DBS poses unique challenges that are not adequately addressed by adult-derived paradigms. OBJECTIVE: To identify key gaps in the...

Cost‐Effectiveness of Radiofrequency Ablation for Benign Non‐Functioning Thyroid Nodules: A Systematic Review

ABSTRACT Purpose This systematic review tests the hypothesis that radiofrequency ablation (RFA) for benign non‐functioning thyroid nodules is associated with favourable cost‐effectiveness compared with surgery. Materials and Methods A systematic literature search of multiple data...

Clinical Meaningfulness and Improvement Thresholds of Myositis Core Set Measures: Association with Patient-Reported Outcomes

Objective The study aimed to evaluate the clinical meaningfulness and improvement thresholds of the myositis core set measures (CSMs) of disease activity in idiopathic inflammatory myopathies (IIM), emphasizing associations with patient-reported outcome measures (PROMs). Methods...