Massachusetts General Hospital

Women, Medicine, and AI

This Viewpoint examines the relationship between women in the health care workforce and artificial intelligence (AI) and highlights opportunities for women to influence the design and use of AI in health care.

MRI Characteristics of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

Importance Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a demyelinating disease distinct from multiple sclerosis (MS) and aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD). Magnetic resonance imaging (MRI) is central t...

mRNA Therapeutics for Skin Rejuvenation: From Aging Atlases to Clinical Translation

ABSTRACT Skin aging is a multifactorial process characterized by the progressive decline of tissue structure, function and regenerative capacity. Although numerous interventions have been developed to improve the clinical manifestations of aging, most primarily alleviate downstre...

Association of antiplatelet and anticoagulant use history with 30-day outcomes after lumbar puncture: a population-based retrospective study

Abstract Objective The safety of lumbar puncture in patients with a history of anticoagulant or antiplatelet use remains incompletely characterized. This study evaluated the coded occurrence of blood patch, paralysis, and spinal decompression within 30 days of lumbar puncture usi...

PD GENEration: an international Parkinson’s disease genetic research study

Abstract Background PD GENEration (NCT04057794, NCT04994015), sponsored by the Parkinson's Foundation in partnership with Aligning Science Across Parkinson’s (ASAP) through the Global Parkinson’s Genetics Program (GP2), is an international, observational, clinical research study...

Cancer survivors’ sleep outcomes across cognitive behavioral therapy for insomnia

Background Insomnia is a frequent and distressing concern for cancer survivors and is often associated with increased risk for depression and anxiety. Although cognitive behavioral therapy for insomnia (CBT-I) has been established as an effective treatment, brief, virtually deliv...

An rRNA hybridization-based approach for rapid and accurate identification of diverse fungal pathogens

species, to identify diverse fungal pathogens. We created a set of 91 probes targeting 86 medically relevant fungal species, designed to recognize regions of differential conservation across taxonomic groupings, from class- to species-specific probes. We assessed assay performanc...

Tunable nanofluidic ion gating via in situ salt precipitation-dissolution

Nanofluidic ion gating underpins both biological signal transduction and iontronic signal processing. However, a simple and reliable mechanism that functions independently of local electrochemical conditions remains unavailable, hindering interference-free integration of artifici...

Reducing Serum Bilirubin Measurements in a Newborn Nursery Using Quality Improvement Methodology

BACKGROUND: Transcutaneous bilirubin (TcB) screening in the newborn nursery (NBN) is noninvasive and appropriate for most infants; however, reported rates of total serum bilirubin (TSB) measurement remain at 17% to 30%. OBJECTIVE: From January to December 2024, 17.2% of infants s...

Temporal Dynamics of Urinary Extracellular Vesicle Excretion and Cargo in Healthy Subjects over 24 Hours

Abstract Urinary extracellular vesicles (uEVs) are promising non-invasive biomarkers of renal physiology and pathology, yet little is known about their temporal excretion patterns or optimal normalization strategies as urine concentrations vary significantly during the day. In th...

Exploratory data analysis of tonometry and PTT/PIR signals for cuffless blood pressure monitoring: dynamic responsiveness versus baseline stability

OBJECTIVE: Sensing modalities for cuffless blood pressure (BP) monitoring remain insufficiently characterized. To address this, we used exploratory data analysis (EDA) to evaluate multimodal physiological signals' associations with reference BP, to gain insight into their BP-rela...

Actionable genetic landscape and dynamics in circulating DNA from 12,827 patients with metastatic breast cancer

Abstract Plasma cell-free DNA (cfDNA) is a sensitive, noninvasive tool for monitoring the genomic landscape, heterogeneity, and evolution of cancer, aggregating genetic information from multiple metastatic sites. Here, we study 15,564 cfDNA samples from 12,827 patients with metas...

Football Cleats and Injury Patterns in 14- to 19-Year-Old Female Football Players: The Effect of Surface, Gender-Specific Shoe Gear and Cleat Pattern

BACKGROUND: Female football (soccer) players are at increased risk for lower extremity injuries, yet prevention strategies remain based mostly on male athlete data. Modifiable extrinsic factors including footwear design and playing surface have not been well defined in youth fema...

T9. BRAIN–BONE CROSSTALK IN SCHIZOPHRENIA-ASSOCIATED OSTEOPOROSIS: FROM BRAIN-CENTERED THERAPY TO BRAIN–BONE CO-TREATMENT

Background Schizophrenia is increasingly recognized as a systemic disorder rather than a purely brain-centered psychiatric disease. Osteoporosis and fragility fractures are underrecognized but clinically important comorbidities in patients with schizophrenia, who often show reduc...

RamanOmics decodes the spatial vibrational–molecular architecture of senescence in aging and repair

Aging and tissue repair involve heterogeneous remodeling across transcriptional, biochemical and cellular dimensions, yet prevailing definitions rely on isolated molecular markers that obscure how these states co-evolve. Here we present RamanOmics, a multimodal framework integrat...

Tumor Vascular Features and Colorectal Cancer–Specific Mortality

Importance The phenotypic and morphologic heterogeneity of tumor vasculature in colorectal cancer (CRC) has been increasingly recognized; however, its clinical importance remains unclear. Objective To examine whether specific tumor vascular features are associated with CRC-specif...

LEVERAGING A NETWORK OF EHR-LINKED BIOBANKS TO INVESTIGATE CLINICAL AND GENETIC RISK FOR PERINATAL DEPRESSION

Perinatal depression (PND) is a depressive illness occurring during pregnancy and up to one year following childbirth. PND affects 10-20% of mothers and can contribute to maternal mortality and morbidity, as well as adverse outcomes in children. Despite increasing interest in ris...

Voices From the Community: How Inpatient Clinicians Experience Caring for Deteriorating Children

BACKGROUND: National initiatives to improve care for children in community emergency department settings have demonstrated improved quality with decreased pediatric mortality. In contrast, pediatric readiness for inpatient care in community hospitals remains poorly defined. Carin...

Portable Low-Field MRI of the Brain in Clinic and Community Settings

This cohort study evaluates portable, low-field magnetic resonance imaging (MRI) against conventional MRI in memory clinic and community cohorts.

Acute Myeloid Leukemia Involving the Skin

ABSTRACT Leukemia cutis (LC) refers to cutaneous infiltration by leukemic cells, most often by acute myeloid leukemia (AML) in adults and by lymphoblastic leukemia in children. Although uncommon, LC is a clinically significant manifestation of extramedullary disease and may prece...