Leipzig University

Comparative performance of portable DNA extraction protocols and bioinformatics workflows for rapid detection of gram-negative bacteria and antimicrobial resistance using Oxford Nanopore sequencing

ABSTRACT Oxford Nanopore Technology (ONT) enables rapid, portable pathogen identification and antimicrobial resistance (AMR) detection, but the reliability of downstream genomic analyses is highly dependent on DNA extraction quality, particularly in resource-limited settings. Thi...

Precursor Design Principles for Area‐Selective Atomic Layer Deposition of Alumina: Quantifying the Role of Lewis Acidity, Steric Repulsion, and Dimerization in Surface Adsorption

ABSTRACT In atomic layer deposition (ALD), precursor adsorption plays a critical role in determining growth characteristics. This is particularly important in area‐selective ALD (AS‐ALD), where adsorption on the non‐growth surface (NGS) leads to selectivity loss. In this context,...

Anticipating the hospital of the future: stakeholder perspectives on 6G technology requirements in health care

PURPOSE: The ongoing 6G standardization process is largely driven by technical advancements, but with limited consideration of sector-specific needs, particularly in health care. The current scientific literature primarily focuses on technical aspects, offering minimal empirical...

Upward transport and segregation of ice-nucleating particles in deep convective clouds

Abstract. Ice-nucleating particles (INPs) play a crucial role in Earth’s weather and climate by influencing cloud properties and precipitation. However, their abundance in the free troposphere, vertical distribution, and transport mechanisms are not well-characterized. This study...

Mechanochemical energy landscapes under force support catch–slip bonds in T-cell activation

Abstract Traditional theories explain T-cell activation using antigen concentration, binding affinity and dissociation rate, but they fail to account for its extraordinary sensitivity. Recent developments in structural biology, biophysics and modelling have motivated the view tha...

The role of general practitioners in German cancer care: a scoping review

Abstract Background General practitioners (GPs) play an important role in the care of patients with cancer across the entire cancer continuum, from diagnosis to palliative care. Despite their broad range of responsibilities, structures to facilitate the systematic involvement of...

Transcriptome Dynamics From Primary Gastric Cancer to Peritoneal Metastases: Translational Insights for Surgical Oncology

BACKGROUND AND AIMS: Peritoneal metastases (PMs) represent the most frequent, clinically challenging dissemination pattern in advanced gastric cancer, especially poorly cohesive (PCGC) subtype, and are associated with poor prognosis. We aimed to characterize the transcriptomic la...

Dystonia 3×3: A Training Guideline for Beginners in Botulinum Neurotoxin Treatment of Cervical Dystonia

Cervical dystonia (CD) is a hyperkinetic movement disorder characterized by involuntary muscle contractions leading to abnormal postures of the head and neck. The injection of botulinum neurotoxin type A (BoNT-A) into the muscles involved is the treatment of choice for CD. BoNT-A...

Programmable hydrodynamics of active particles

Abstract Self-propelled microparticles create flow fields that determine how they interact with surfaces, external flows, and each other. These flow fields fall into distinct classes–pushers, pullers, and neutral swimmers–each exhibiting fundamentally different collective behavio...

Effort-Reward Imbalance, related risk factors and the association with depression and suicidal ideation in German dentists- BMC Psychology

Abstract Background Dentistry involves substantial physical, psychological, and organizational demands. Increasing administrative tasks and structural changes in dental health care may exacerbate imbalances between professional effort and rewards. According to the Effort-Reward I...

Exploring self-regulatory processes in League of Legends using think-aloud

Although self-regulation is widely recognised as central to performance in traditional sport, esports research often relies on retrospective or self-report measures, offering limited insight into how players regulate cognition, emotion, and behaviour in real time. This novel stud...

Machine learning provides individualized prediction of outcomes after first complete remission without allo‐HSCT consolidation in adult acute myeloid leukemia—A HARMONY study

Abstract Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is a curative treatment option for a significant proportion of patients with acute myeloid leukemia (AML), and it is generally recommended when the relapse risk without allo‐HSCT outweighs the estimated non‐r...

Growth parameters and IGF-1 axis biomarkers differ among omnivorous, vegetarian, and vegan children

Abstract Purpose Whereas an increasing number of families choose a vegan or a vegetarian diet, the effects of a plant-based nutrition on height and BMI of children and their IGF-1- and IGFBP-3-serum concentrations as measures for growth and development are not entirely described....

Overview of the re‐evaluation of trace elements as nutritional feed additives in the European Union : characterization, safety, and efficacy

The re-evaluation of feed additives in the European Union was outlined in the Regulation (EC) No 1831/2003. The primary objectives were to ensure safety and verify efficacy, as well as to update authorizations and phase out unsafe additives or those in which the industry expresse...

Towards an open registry of Earth observation instruments

Abstract. Earth observation (EO) is essential to understanding the Earth system, enabling the transformation of planetary properties into measurable variables that can be analysed, compared, and modelled. In recent decades, EO capabilities have grown rapidly, accompanied by an ev...

LDL Cholesterol Lowering With Evolocumab Before Percutaneous Coronary Intervention for Acute Myocardial Infarction

Importance: Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibition is recommended as second- or third-line lipid-lowering therapy after myocardial infarction (MI), resulting in prolonged periods of inadequate low-density lipoprotein cholesterol (LDL-C) control. Whether...

Sample size shapes metabarcoding-driven biodiversity assessments across body sizes in soil

Understanding how sample size influences biodiversity detection across taxonomic groups differing in body size is critical for designing robust and cost-efficient metabarcoding studies of soil eukaryotes. Using a soil mass gradient (0.25-32 g) combined with a universal 18S rRNA m...

A Peter–Weyl theorem for compact group bundles and the geometric representation of relatively ergodic compact extensions

We show that a relatively ergodic extension of measure-preserving dynamical systems has relative discrete spectrum if and only if it can be represented as a skew-product by a bundle of compact homogeneous spaces. Our result holds without restrictions on the acting group or the un...

From peaks to plummets—linking sleep, effort, and absorption to trajectories of energetic activation during the day

Abstract This study examines daily energy trajectories at work from a temporal self-regulation perspective, addressing the paradoxical finding that effort can be both energizing and depleting. Rather than treating daily energy curves as purely descriptive, we distinguish three se...

Real-World Therapy with Eravacycline for Complex Infections Caused by Carbapenem-Resistant Pathogens with a Focus on Patients with Severe Burns

The purpose of this study was to describe the clinical outcomes in patients with complex infections caused by carbapenem-resistant pathogens who were treated with eravacycline (ERV) containing regimens. A retrospective chart review was conducted at Hospital St. Georg in Leipzig,...