Leipzig University

Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network

Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially)...

Moser–Tardos Algorithm with small number of random bits

We study a variant of the parallel Moser–Tardos Algorithm. We prove that if we restrict attention to a class of problems whose dependency graphs have subexponential growth, then the expected total number of random bits used by the algorithm is constant; in particular, it is indep...

On-demand therapies–emergency medication or daily routine?

Abstract Fluctuations represent a major therapeutic challenge in Parkinson’s disease (PD) and become increasingly prevalent with disease progression. While oral and device-aided therapies (DAT) improve symptom control, patients continue to experience disabling OFF episodes, in pa...

Curriculum for Bioimaging Data Stewardship: A Systematic Review of Existing Training Resources

Abstract The increasing complexity and volume of biological imaging data require structured and sustainable research data management to ensure reproducibility, reusability, and compliance with FAIR (Findable, Accessible, Interoperable, and Reusable) principles. In this context, D...

War-related and psychological predictors of experiential and physiological fear of war in Germany: findings from a nationally representative survey

Abstract Background Fear of war has emerged as a relevant psychosocial phenomenon in Europe, yet little is known about factors associated with its experiential and physiological dimensions in representative populations. This study examined sociodemographic, war-related, and psych...

Psychotherapy remission prediction models show limited cross-clinic generalizability in routine outpatient care

Abstract Clinical prediction models for psychotherapy outcomes have the potential to assist therapists in planning a patient’s individual treatment, but their clinical utility depends on maintaining predictive performance across settings. We assessed prediction of post-treatment...

Beyond the Static Approximation: Assessing the Impact of Conformational and Kinetic Broadening on the Description of TADF Emitters

Abstract Thermally activated delayed fluorescence (TADF) is a promising route toward high-efficiency, metal-free organic light-emitting diodes (OLEDs). However, the characterization of TADF kinetics in solid-state thin films is often complicated by pronounced multiexponential pho...

Teaching staff as gatekeepers for student mental health in higher education: findings from an exploratory sequential mixed-methods study on mental health promotion, psychological crises, and stigma

Abstract Background Mental health problems among university students are highly prevalent, while stigma and limited help-seeking remain major barriers to support utilization. Teaching staff can act as important gatekeepers who recognise distress, encourage help-seeking, and contr...

Evaluation of inert gases as alternatives to Carbon Dioxide for stunning pigs: effects on gas stability, effectiveness and animal welfare

The European Union requires pigs to be stunned before slaughter, with Carbon Dioxide (CO₂) being the most common method, although it is increasingly criticized for its aversiveness. This study evaluated inert gases for stability, effectiveness, and animal welfare. Ten gas mixture...

Enhanced survival through repeated photodynamic therapy and almost complete tumor regression by prior radiation therapy in an orthotopic rat bladder cancer model

Abstract Introduction The development of new organ-preserving treatment alternatives is still an important issue in bladder cancer (BCa) research. A combination of minimally-invasive photodynamic therapy (PDT) with ionizing radiation (IR) could be beneficial for bladder tumor reg...

The orientation of cholesterol’s hydroxy group affects its membrane dynamics and intracellular transport

The brain, though less than 10% of body mass, contains about 25% of total cholesterol (CHL), emphasizing CHL's key role in neuronal function. Many actions of CHL are stereospecific, as shown by differences from its 3 α -hydroxy epimer, epicholesterol (epiCHL). How this minor stru...

Tearing Down Scientific Boundaries: Frontiers in Medicinal Chemistry 2026

The Frontiers in Medicinal Chemistry (FiMC) was held in Münster from March 24 th to 27 th as the largest international Medicinal Chemistry conference in Germany. Welcoming more than 240 participants from around 20 countries, it was a vibrant conference, celebrating the community...

GUTchetp: integrated prediction of gut microbial biotransformation profiles using ensemble monolingual and multilingual neural machine translation and enzyme class consistency–reaction similarity

The analysis of the metabolic fate of chemical compounds in the human gut remains a fundamental challenge, as comprehensive experimental characterization across the vast chemical space is infeasible. Moreover, despite progress in computational biology, a comprehensive tool for pr...

Multimodal fertility cues in chimpanzees: how body odours complement sexual swellings

Abstract To attract mating partners, female mammals communicate their reproductive status through one or multiple sensory modalities, providing redundant or complementary information. Chimpanzees ( Pan troglodytes ) are an excellent model for studying multimodal communication. Ex...

Coronary artery calcification score as a prognostic factor in patients undergoing allogeneic stem cell transplantation – a retrospective analysis

Abstract Background Coronary artery calcification (CAC) scoring can be measured as a by-product of computed tomography (CT). CAC scoring reflects the general cardiovascular risk profile of patients. The aim of the present study was to determine the prognostic role of CAC on overa...

Barriers, challenges, and facilitators in oral health care for older adults in home-based care: stakeholder perspectives from germany

Abstract Background With the growing number of people requiring long-term care in Germany, not only is the prevalence of chronic diseases increasing, but oral health is also deteriorating. Many older adults with functional impairments who live at home can no longer maintain their...

From Conflict to Coordination: Children as Strategic Problem Solvers in Social Dilemmas

Human cooperation requires resolving social dilemmas—situations in which individual interests conflict with what is best for the group. A growing body of work has begun to explore how children develop and implement solutions to these conflicts, shedding new light on the developme...

Invited perspectives: Towards usable compound event research

Abstract. Supporting stakeholders with science-based decision-making to mitigate and adapt to climate change impacts is a central mandate of the climate research community. In particular, mapping out scenario-dependent climate risk landscapes is one of the most pressing challenge...

From Inhibitor to Reporter: Nirmatrelvir-Derived Fluorogenic Substrates for the SARS-CoV-2 Main Protease

The SARS-CoV-2 main protease (Mpro) is a key antiviral drug target due to its essential role in the pathogen's replication cycle. The development of potent next-generation Mpro inhibitors is of great importance to ensure the availability of safe and effective COVID-19 therapeutic...

Comparative performance of portable DNA extraction protocols and bioinformatics workflows for rapid detection of gram-negative bacteria and antimicrobial resistance using Oxford Nanopore sequencing

ABSTRACT Oxford Nanopore Technology (ONT) enables rapid, portable pathogen identification and antimicrobial resistance (AMR) detection, but the reliability of downstream genomic analyses is highly dependent on DNA extraction quality, particularly in resource-limited settings. Thi...