Kyoto University

Flow-driven lumen remodeling and valve opening in the vas deferens

ABSTRACT Biological ducts must transport fluids while preserving structural integrity, yet how mechano-signaling coordinates wall deformation with luminal flow in vivo remains unclear. Here we combine intravital two-photon excitation microscopy, light-sheet imaging and FRET-based...

Cohesin prevents local mixing of condensed euchromatic domains in living human cells

The human genome is folded into chromatin loops by the cohesin complex, forming functional chromatin domains that underlie transcription and DNA replication/repair. However, how cohesin organizes these domains in living cells, especially in active euchromatin, remains elusive. To...

Life Cycle Assessment of Automobile Parts Made of Cellulose Nanofiber-Reinforced Bio-Polyethylene Using the Pulp Direct Kneading Method

The development of cellulose nanofiber-reinforced plastics (CNFRPs) is a possible option for reducing the environmental impact of plastic products, such as automotive components. This study conducted a life cycle assessment (LCA) of CNF-reinforced bio-polyethylene (CNF-BioPE) as...

Tirzepatide Benefit for Early Glycemic and Weight Management in People with T2D in Japan: Rationale, Design, and Baseline Characteristics of T-BEAT Study

Tirzepatide has demonstrated good efficacy and safety in the management of type 2 diabetes (T2D) in clinical trials. As the importance of early intensive intervention is known, the tirzepatide benefit for early glycemic and weight management (T-BEAT) study investigated the real-w...

The monochromatic Hahn-Wilson conjecture

Abstract We prove the $K(n)$ K ( n ) -local analogue of the Hahn-Wilson conjecture on fp-spectra, which states that the truncated Brown-Peterson spectra generate the category of fp-spectra as a thick subcategory. As a corollary, we deduce the original conjecture at height 1. Alon...

Chaotic Origin of Tsirelson Bound

We report a rigorous, deterministic origin for quantum non-locality and the Tsirelson bound (2 2) by revealing profound macroscopic emergent properties hidden within exactly solvable chaos towers under a strictly fixed invariant Cauchy measure (γ = 1). While evaluating joint corr...

A honey trap for Platycerus (Coleoptera: Lucanidae): Georeferenced captures indicate forest-habitat patterns in operational broadleaf forestry

Biodiversity-oriented broadleaf forestry needs practical indicators that translate local forest-habitat conditions into information useful for silvicultural and operational decisions. Here, we used the Female-attracted Flight Interception Trap (F-FIT) to quantify spatial variatio...

Serum C4/C3 ratio at disease onset predicts end-stage renal disease in microscopic polyangiitis: the multicentre REVEAL cohort

We investigated whether serum complement C3 and C4 levels and the C4/C3 ratio at disease onset were associated with clinical features, renal involvement, and prognosis in microscopic polyangiitis (MPA). Patients were stratified into tertiles according to baseline C3 and C4 levels...

Artificial intelligence in cellular senescence research: a systematic review assessing methodological quality and reporting standards using PROBAST + AI and TRIPOD + AI

Cellular senescence is a fundamental mechanism of biological ageing that has emerged as a critical target for therapeutic intervention in age related diseases. The coalesce of artificial intelligence and senescence research provides unprecedented opportunities in advancing our kn...

Finite-sample Testing of Average Out-of-specification-rate Claims: A Learn-then-test Framework for Design-space Candidates

Abstract Purpose Predictive performance can identify a design-space candidate but cannot establish its quality claim. We developed a finite-sample procedure for a prespecified average out-of-specification (OOS) rate claim under a reference plan. Methods Construction data ranked o...

Denitrative Cyanation of Nitroalkanes by Nucleophilic Substitution through Anion–Radical Coupling

Abstract We report a photocatalytic denitrative cyanation to directly convert nitroalkanes into nitriles under mild conditions. The reaction proceeds rapidly under blue LED irradiation and exhibits broad functional-group tolerance. Mechanistic investigations support an anion–radi...

Evaluation of clinical prognostic factors for radium-223 therapy in castration-resistant prostate cancer with bone metastases: the KYUCOG-1901 study

We evaluated clinical factors associated with symptomatic skeletal events (SSEs), radiographic progression-free survival (rPFS), and overall survival (OS) in patients with metastatic castration-resistant prostate cancer (mCRPC) and bone metastases treated with radium-223 (Ra-223)...

Concise Total Synthesis of Streptospherin A

Abstract A practical total synthesis of streptospherin A (1), a cancer stem cell inhibitor, is reported. The key intermediates are obtained stereoselectively in a concise synthesis by a combination of asymmetric allylation and hydroxy-directed stereoselective diboration. These in...

Effect of Machine Cover on Thermal Behavior of a Turning Center Under Environmental Temperature Changes

Environmental temperature changes are a major factor in machining accuracy degradation in machine tools. As maintaining a constant environmental temperature is costly, reducing thermal deformation through machine design is important. For this purpose, it is essential to clarify t...

High-temperature-treated soy protein isolate reduces amino acid availability and alters social novelty in mice

Abstract High-temperature (HT) treatments above 100 °C are important in food processing; however, their effects on the nutritional value of moist heat-treated proteins are less understood. Therefore, this study examined the impact of HT at 121 °C on soy protein isolate (SPI) in w...

Statistics of Solar Filament Mass Based on CHASE Sun-as-a-star Spectroscopic Observations

Abstract Filaments are cool and dense plasmas suspended in the hot corona of the Sun and other stars. Accurately estimating their masses is of great significance for understanding subsequent eruptions and induced space weather effects, but it remains hindered by their intrinsic g...

Epidemiology of macular dystrophy in Japan (2011–2020): a nationwide population-based study

Abstract Purpose To describe the characteristics and prevalence of macular dystrophy using a comprehensive national claims database in Japan. Study design Population-based retrospective study using a nationwide claims database. Methods Approximately 126 million individuals covere...

Discrete Pitch-Angle Conditions for Helicoidal Stacking of Periodically Corrugated Rods

Helical laminates, in which fibrous elements are stacked while rotating by a constant angle from one layer to the next, are common in natural and artificial materials, including Bouligand structures and fiber-reinforced composites. This study clarifies the geometric pitch-angle c...

Development of quality indicators for diabetes care in community pharmacies: a modified Delphi method

Abstract Background Type 2 diabetes is a common chronic condition requiring continuous management. Without a healthy lifestyle and regular treatment, it can lead to severe complications that greatly reduce the patients’ quality of life. Although support for medication management...

Assessing Disaster Preparedness and Recovery from Tropical Cyclones in Zimbabwe: Insights from Cyclone Ana in Nyanga

Abstract Tropical cyclones pose increasing risks in Southern Africa, with impacts shaped not only by hazard intensity but also by underlying vulnerabilities and disaster risk management (DRM) capacity. This study examines preparedness, response, and recovery following Cyclone Ana...