Kyoto University

P1.094. Cooporation of Aldh2 Deficiency and Tp53 Loss in Alcohol-Mediated Esophageal Squamous Field Cancerization

Abstract Topic Esophageal Cancer: Esophageal Carcinogenesis Background Field cancerization in the upper aerodigestive tract is driven by alcohol, ALDH2 polymorphism, and TP53 mutation. However, animal models reflecting these factors are lacking. This study aims to clarify the com...

Universal Mass Gap Formula ∆m = m0 ln K: Spontaneous Kubo-Martin-Schwinger State Emergence with Maximal Quantum Chaos

We demonstrate that quark confinement and a non-zero quantized mass gap naturally emerge from deterministic, exactly solvable chaotic dynamics. Crucially, the fluctuation spectrum is natively quantized by discrete Lyapunov exponents λL = lnK, yielding a universal logarithmic mass...

Geneformer-guided multiomics integration identifies Pbx1 as a network hub of hematopoietic stem cell aging

Hematopoietic stem cells (HSCs) constitute an organized hematopoietic system that undergoes age-related alterations, including increased platelet production and decreased erythropoiesis. The fundamental mechanisms driving these shifts remain incompletely understood. We used singl...

Clinical significance of inhaled COPD therapy in advanced or recurrent non-small cell lung cancer in the immune checkpoint inhibitor era: a multicenter retrospective cohort study

Immune checkpoint inhibitors (ICIs) have markedly improved survival in advanced non–small cell lung cancer (NSCLC), potentially modifying the prognostic impact of comorbid chronic obstructive pulmonary disease (COPD). We conducted a multicenter retrospective cohort study across f...

Comparative Analysis of Ion and Electron Contributions to Ionospheric Ionization at Auroral and Subauroral Latitudes

Abstract Electron and proton precipitation into the nightside ionosphere is a key process in magnetosphere–ionosphere coupling. Although auroral electron precipitation at –10 keV is traditionally considered the main driver of auroral emissions, recent studies show that keV electr...

The Evolutionary Paradox of Human Intelligence ー Why Intelligence Does Not Eliminate War

The dynamics described here parallel cultural narratives such as the Tower of Babel.In that story, a collectively constructed symbolic structure expands until it exceeds the constraints of the external world,after which the shared referential network collapses and language fragme...

Programming Backpropagation with Reverse Handlers for Arrows

We introduce a new programming language and its categorical semantics in order to design and implement neural networks within the framework of algebraic effects and handlers for arrows. Our language enables us to construct neural networks symbolically, in the same manner as algeb...

The Clinicopathological Characteristics and Prognosis of Cholangiolocarcinoma: A Multicenter Study With a Central Pathology Review

BACKGROUND: Cholangiolocarcinoma (CLC) is a rare liver cancer with ≥ 80% ductular configuration (DC). Given its rarity, its clinicopathological characteristics remain poorly understood, and its status as a distinct disease entity remains controversial. We conducted a nationwide m...

Chikungunya fever among Japanese travelers: monthly and yearly trends in imported cases, 2011–2023

Objectives: Chikungunya poses an increasing threat to people living in endemic areas and to travelers from non-endemic regions. This study descriptively characterized imported chikungunya cases in Japan and explored the relationship between local incidence in destination areas an...

BSFT-like action from cohomomorphism

Abstract By performing a field redefinition via a cohomomorphism on the Maurer-Cartan action of the A∞ algebra, we construct an action that reproduces the characteristic structure of boundary string field theory (BSFT), which we refer to as the BSFT-like action. We show that the...

Homologous knock-in processes facilitated by CRISPR-Cas9 in Aurantiochytrium and disrupting the gene for DNA ligase IV prevents transformation events

Abstract This study explores advanced molecular breeding techniques for Aurantiochytrium limacinum , a eukaryotic microorganism valued for its industrial production of DHA and astaxanthin. We first employed the CRISPR-Cas9 system to simultaneously disrupt two genes: crtIBY , a mu...

Hydrogel-EmpoweredInterfacial Reactive Hydrogen onCopper Enables Selective Nitrate-To-Ammonia Electrocatalysis

Abstract Precise control of interfacial reactive hydrogen is crucial for improving the selectivity of proton-coupled electron transfer reactions in electrocatalysis. In the nitrate electroreduction to ammonia reaction, a fundamental trade-off is identified for copper (Cu)-based c...

Supramolecular Polymerization and Morphological Transformation of Dynamic Helical Poly(Phenylacetylene)s via Chain‐End Host–Guest Interactions

ABSTRACT Integration of dynamic helical polymers with supramolecular polymerization offers a promising strategy for constructing adaptive hierarchical chiral materials. However, the transformation of molecular‐level conformational changes in dynamic helical polymers into structur...

Coupled Electron–IonTransfer Drives NickelNanofilm Formation at a Water-Free Deep Eutectic Solvent/Oil Interface

Abstract Nickel nanofilms were prepared at an ethaline/toluene interface, which is a water-free deep eutectic solvent (DES)/oil (O) interface, where the absence of water enables a unique environment for interfacial redox chemistry. When NiCl42– in ethaline was contacted with deca...

3D Hierarchical Water‐Salt Transport Networks for Highly Efficient Solar‐Driven Interfacial Evaporation

ABSTRACT Solar‐driven interfacial evaporation (SDIE) offers a sustainable pathway for freshwater production, yet conventional hydrogel evaporators are hindered by high pore tortuosity, prolonged diffusion pathways, and interfacial salt accumulation that severely compromise long‐t...

Single-Dose L-Lysine-Induced Pancreatitis Followed by Pancreatic Neoplastic Progression in Adult Kras/Trp53-Driven Mice

Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal malignancy, highlighting the need for reproducible experimental systems that model pancreatic injury and subsequent neoplastic progression. Adult-onset genetically engineered models in which oncogenic Kras and mutant...

A hydro-mechanical mechanism for cyclic ratcheting of embedded cantilever retaining walls in saturated sand

Saturated backfills behind embedded cantilever walls deform through coupled hydro-mechanical processes that pseudo-static methods cannot capture. Three 40 g dynamic centrifuge tests are presented to isolate how the pre-seismic static state, set by wall flexural stiffness, togethe...

Smartphone-measured heart rate variability and quality of life in patients with gynecological cancer: a multicenter prospective study

In this study, we aimed to investigate the association between heart rate variability (HRV) and quality of life (QoL) in patients with gynecological cancer and examine whether continuous HRV monitoring may help identify QoL deterioration. This multicenter, prospective, observatio...

Auroral Belts as Magnetically Localized Reactors for Prebiotic Chemistry on Early Earth

Most models of prebiotic chemistry emphasize globally distributed or widely acting energy sources, including ultraviolet radiation, lightning, impacts, and energetic particles. However, spatially localized environments capable of repeatedly concentrating reactive chemistry may al...

Auroral Belts as Magnetically Localized Reactors for Prebiotic Chemistry on Early Earth

Most models of prebiotic chemistry emphasize globally distributed or widely acting energy sources, including ultraviolet radiation, lightning, impacts, and energetic particles. However, spatially localized environments capable of repeatedly concentrating reactive chemistry may al...