Institution
Kyoto University
Recent research
- BiologyOpen access
Multiheme selenoenzyme essential for elemental sulfur respiration
Abstract Microbial reduction of elemental sulfur is a pivotal process in the global sulfur cycle 1 . Insoluble elemental sulfur can serve as a terminal electron acceptor during anaerobic respiration, producing sulfide 2,3 . However, the molecular mechanisms underlying sulfur redu...
- Climate & EnvironmentOpen access
Spontaneous segmentation of slow slip events on a homogeneous planar fault
Abstract Slow slip events (SSEs) are transient aseismic fault slip events that often display segmentation along strike. While fault segmentation is commonly attributed to physical heterogeneities, numerical studies have shown that segmentation can also occur on homogeneous planar...
- AI & ComputingOpen access
Boundedness of Composition Operators in Orlicz–Morrey Spaces
ABSTRACT In this paper, we investigate the necessary and sufficient conditions for the boundedness of composition operators on Orlicz–Morrey spaces. Our results encompass Lebesgue and generalized Morrey spaces as special cases. In addition, we characterize the boundedness of comp...
- Physics & SpaceOpen access
Environmental Energetics of Multicellularity
Complex differentiated multicellularity entails energetic demands associated with cellular differentiation, adhesion, communication, and division of labor. Here, I propose environmental energetics as a heuristic framework for considering how environmentally structured energy beco...
- Physics & SpaceOpen access
Auroral Belts as Magnetically Localized Reactors for Prebiotic Chemistry on Early Earth
Most models of prebiotic chemistry emphasize globally distributed or widely acting energy sources, including ultraviolet radiation, lightning, impacts, and energetic particles. However, spatially localized environments capable of repeatedly concentrating reactive chemistry may al...
- BiologyOpen access
11β-HSD2 buffers fetal glucocorticoid exposure inducing Per1 expression under maternal stress
Abstract Glucocorticoids (GCs) have been proposed as maternal-fetal communication signals. However, fetal circadian rhythms are initially shielded from maternal entrainment, in addition to delayed circadian clock emergence due to CLOCK suppression. Premature CLOCK/BMAL1 activatio...
- Health & MedicineOpen access
Abstract Background Hepatocellular carcinoma (HCC) ranks as the fifth most common cancer globally and the third leading cause of cancer-related death. Systemic therapies such as lenvatinib or the combination of atezolizumab and bevacizumab has recently emerged as a first-line the...
- Health & Medicine
Abstract Topic Esophageal Cancer: Esophageal Carcinogenesis Background Field cancerization in the upper aerodigestive tract is driven by alcohol, ALDH2 polymorphism, and TP53 mutation. However, animal models reflecting these factors are lacking. This study aims to clarify the com...
- Physics & SpaceOpen access
We demonstrate that quark confinement and a non-zero quantized mass gap naturally emerge from deterministic, exactly solvable chaotic dynamics. Crucially, the fluctuation spectrum is natively quantized by discrete Lyapunov exponents λL = lnK, yielding a universal logarithmic mass...
- BiologyOpen access
Hematopoietic stem cells (HSCs) constitute an organized hematopoietic system that undergoes age-related alterations, including increased platelet production and decreased erythropoiesis. The fundamental mechanisms driving these shifts remain incompletely understood. We used singl...
- Physics & SpaceOpen access
The Evolutionary Paradox of Human Intelligence ー Why Intelligence Does Not Eliminate War
The dynamics described here parallel cultural narratives such as the Tower of Babel.In that story, a collectively constructed symbolic structure expands until it exceeds the constraints of the external world,after which the shared referential network collapses and language fragme...
- Physics & SpaceOpen access
Abstract Electron and proton precipitation into the nightside ionosphere is a key process in magnetosphere–ionosphere coupling. Although auroral electron precipitation at –10 keV is traditionally considered the main driver of auroral emissions, recent studies show that keV electr...
- Health & MedicineOpen access
Immune checkpoint inhibitors (ICIs) have markedly improved survival in advanced non–small cell lung cancer (NSCLC), potentially modifying the prognostic impact of comorbid chronic obstructive pulmonary disease (COPD). We conducted a multicenter retrospective cohort study across f...
- AI & ComputingOpen access
Programming Backpropagation with Reverse Handlers for Arrows
We introduce a new programming language and its categorical semantics in order to design and implement neural networks within the framework of algebraic effects and handlers for arrows. Our language enables us to construct neural networks symbolically, in the same manner as algeb...
- Materials & EnergyOpen access
Abstract This study explores advanced molecular breeding techniques for Aurantiochytrium limacinum , a eukaryotic microorganism valued for its industrial production of DHA and astaxanthin. We first employed the CRISPR-Cas9 system to simultaneously disrupt two genes: crtIBY , a mu...
- Health & MedicineOpen access
BACKGROUND: Cholangiolocarcinoma (CLC) is a rare liver cancer with ≥ 80% ductular configuration (DC). Given its rarity, its clinicopathological characteristics remain poorly understood, and its status as a distinct disease entity remains controversial. We conducted a nationwide m...
- Health & MedicineOpen access
Chikungunya fever among Japanese travelers: monthly and yearly trends in imported cases, 2011–2023
Objectives: Chikungunya poses an increasing threat to people living in endemic areas and to travelers from non-endemic regions. This study descriptively characterized imported chikungunya cases in Japan and explored the relationship between local incidence in destination areas an...
- Materials & EnergyOpen access
BSFT-like action from cohomomorphism
Abstract By performing a field redefinition via a cohomomorphism on the Maurer-Cartan action of the A∞ algebra, we construct an action that reproduces the characteristic structure of boundary string field theory (BSFT), which we refer to as the BSFT-like action. We show that the...
- Materials & EnergyOpen access
Abstract Nickel nanofilms were prepared at an ethaline/toluene interface, which is a water-free deep eutectic solvent (DES)/oil (O) interface, where the absence of water enables a unique environment for interfacial redox chemistry. When NiCl42– in ethaline was contacted with deca...
- Materials & Energy
Abstract Precise control of interfacial reactive hydrogen is crucial for improving the selectivity of proton-coupled electron transfer reactions in electrocatalysis. In the nitrate electroreduction to ammonia reaction, a fundamental trade-off is identified for copper (Cu)-based c...