Kyoto University

Muscle mechanical properties during voluntary contraction with motor-threshold neuromuscular electrical stimulation

Abstract Neuromuscular electrical stimulation (NMES) is often superimposed on voluntary contraction, but its effects on muscle mechanical properties remain unclear. We used shear wave elastography to assess the tibialis anterior at rest and during isometric ankle dorsiflexion wit...

An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation

Heterozygous carboxyl-terminal variants in the RHO guanosine triphosphatase (GTPase) CDC42 are known to cause severe autoinflammatory syndromes. Here, we identified a heterozygous amino-terminal p.T43I (Thr 43 →Ile) CDC42 variant in patients with autoinflammation and uncovered a...

Non-communicable disease care delivered by emergency medical teams during the Gaza Health Response in 2024–2025: an observational analysis of WHO Minimum Data Set Reports

The objective is to describe patterns of noncommunicable disease (NCD) service delivery and the operational roles of the different Emergency Medical Team (EMT) types-Type1 mobile (outpatient mobile primary care), Type1 fixed (outpatient static primary care), and Type2 (inpatient...

A genotype-first approach reveals the molecular basis of pyrin inflammasome activation

Mutations in the MEFV gene, which encodes pyrin, are associated with a spectrum of inflammatory conditions called pyrin-associated autoinflammatory diseases (PAADs). Of the 400 MEFV variants listed in the Infevers database, most are classified as variants of uncertain significanc...

Every non-trivial knot group is fully residually perfect

Abstract Given a class script upper P <mml:math xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mnf="http://cambridge.org/core/manifest" xmlns:cup="http://contentservices.cambridge.org" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:m="http://cambridge.org/core/metadata" x...

From Environmental Structure to Biodiversity: The Referential Function of Life

Darwinian natural selection explains how advantageous traits become established through differential survival and reproduction, but it provides a less direct explanation for how organisms progressively acquire novel adaptive capacities and generate increasing biological diversity...

Genetic characterizations and seroprevalence of hepatitis B virus among non-human primates and human caretakers in Indonesia

Hepatitis B virus (HBV) is a major human pathogen also detected in non-human primates (NHPs), yet its cross-species and zoonotic transmission potential remains poorly defined. We screened 237 NHPs across 10 species together with 65 human caretakers from four major Indonesian isla...

Flexible cognition, perceived conflict, and self-monitoring in autism spectrum condition

Social adaptation often requires balancing interpersonal conflict with flexible responses to others’ expectations and self-monitoring. However, the mechanisms linking these processes remain unclear. This preliminary study aimed to examine whether perceived interpersonal conflict...

Death, Deprivation, and the Symmetry Problem

ABSTRACT According to the deprivation account of the badness of death, death is bad for the one who dies because it deprives her of goods she would otherwise have enjoyed. This view faces the so‐called symmetry problem when one considers prenatal nonexistence. Scholars have propo...

MedKGent: a large language model agent framework for constructing temporally evolving medical knowledge graph

The rapid expansion of medical literature challenges the scalable structuring of domain knowledge. Knowledge Graphs (KGs) offer a solution, yet current construction methods lack generalizability and ignore the temporal dynamics of evolving knowledge. To address this, we introduce...

Potential EnergySurfaces of Environment-SensitiveFlapping Fluorophores: FLAP

Abstract A series of FLAP molecules are one of the functional fluorescent probes that can sense subtle changes in local environments such as viscosity, polymer free volume, and external mechanical force. In this work, potential energy surfaces (PESs) of a representative Flexible...

Rearing history, larval density, and larval developmental stage affect volatile- and light-mediated diel hiding behavior in Mythimna unipuncta

<title>Abstract</title> Our previous study has shown that plant volatiles and light jointly influence the diel hiding behavior of <italic>Mythimna unipuncta</italic> larvae using the third instars of the laboratory colony. Here, we investigated the effect of rearing history, larv...

Diversity on the Plate: The Quest for Inclusion and the Challenges of Providing Halal School Meals in Japan

Japanese public elementary school lunch (gakkō kyūshoku) programs play a vital role in providing affordable, nutritious meals while fostering communal dining and food education (shokuiku). However, these programs often fail to accommodate religious and cultural dietary needs, lea...

Universal Mass Gap Formula ∆m = m0 ln K: Spontaneous Kubo-Martin-Schwinger State Emergence with Maximal Quantum Chaos

We demonstrate that quark confinement and a non-zero quantized mass gap naturally emerge from deterministic, exactly solvable chaotic dynamics. Crucially, the fluctuation spectrum is natively quantized by discrete Lyapunov exponents λL = lnK, yielding a universal logarithmic mass...

Monitoring pedestrian walking dynamics under environmental and policy influences in urban spaces

Abstract Understanding how environmental conditions and policy interventions jointly shape pedestrian mobility is essential for designing resilient, adaptive, and human-centered urban spaces. This study presents a computer-vision framework that extracts pedestrian trajectories fr...

Neural Assimilation and Accommodation in Trilinguals: An fMRI Study at 7 T

Understanding how multiple languages are represented in the multilingual brain is critical to theories of multilingual assimilation and accommodation. Whether a second language (L2) recruits native-like networks (assimilation) or engages additional neural resources (accommodation...