Kyoto University

Damage identification and model updating using bridge displacement under moving vehicles with uncertain weight

Bridge damage incurred during long-term service leads to discrepancies between the physical structure and its digital twin finite element (FE) model, necessitating regular model updates to ensure reliable health monitoring. Traditional methods typically adopt a two-step framework...

New Δ246p53 isoform responds to DNA damage to enhance p53 family functions in cellular senescence

Abstract p53 is, without a doubt, one of the most powerful genes in our genome, as it makes growth vs arrest, repair vs replacement, catabolism vs anabolism, life vs death decisions in the cell. An alteration or malfunction in p53 may lead to cancer, degeneration or premature age...

RBD-down stabilization of SARS-CoV-2 spike enhances cross-neutralizing antibody responses by redirecting immunodominance toward conserved epitopes

The continuous emergence of SARS-CoV-2 variants has enabled partial escape from neutralizing antibodies, necessitating frequent updates of vaccine antigens. These observations motivate vaccine strategies that can redirect antibody responses toward conserved regions of the spike (...

Emotional predictors of returning a favour: Behavioural experiments in the United States and Japan

Abstract We examined emotional predictors of favour‐returning behaviour in the United States (Study 1) and tested whether the findings in the United States would replicate in a culturally different context in Japan (Study 2). In both experiments, participants played a collaborati...

Genomic global epidemiology and evolution of Escherichia coli ST131 clade A

During the 2010s, Escherichia coli ST131 clade A tested sensitive to most antibiotics. In the 2020s, Europe experienced outbreaks of fluoroquinolone-resistant ST131-A that contained CTX-M β-lactamases and OXA-48-like carbapenemases. We investigated the acquisition of different an...

Potent Antivirals for Respiratory Syncytial Virus Detected via Peptide-Based Fusion Inhibitor Screening

Abstract The respiratory syncytial virus (RSV) causes fatal pneumonia in neonates, infants, and older adults. However, no approved antiviral drugs exist for RSV; furthermore, the currently available antibody-based therapies are expensive and do not provide complete protection aga...

Molecular Connectivity Controls Electronic Coupling and Charge-Transfer Dynamics at Anthracene–MoS2 Interfaces

Abstract Controlling interfacial charge-transfer (CT) interactions is a central challenge in two-dimensional (2D) organic–inorganic hybrid materials. Here, we show that molecular connectivity strongly governs excited-state evolution at a 2D heterointerface using anthracene (An) d...

Quality of life in hyperkalemia: baseline analysis of a cohort study of management of hyperkalemia in patients with chronic kidney disease or heart failure in Japan

Abstract Background Hyperkalemia is common in chronic kidney disease (CKD) and chronic heart failure (CHF), often leading to treatment dilemmas regarding renin–angiotensin–aldosterone system (RAAS) inhibitors. Although potassium binders and dietary restrictions are central to chr...

Construction of signed distance functions through an elliptic equation

Motivated by recent advances in structural optimization, we propose a novel method for constructing the distance function to the boundary of a given domain. Building on and extending the celebrated Varadhan asymptotic theory, our approach reformulates the governing equation into...

The dimensions and realization mechanism of brand Jing-Jie(境界) initiated by brand ritual behaviours: a grounded analysis inspired by Chinese Zen Jing-Jie(境界) theory

Purpose This research seeks to explain the phenomenon of consumers' internal growth initiated by brand ritual behaviours, by establishing a novel construct “brand Jing-Jie(境界)”, inspired by Chinese Zen Jing-Jie(境界)theory. The connotation of “brand Jing-Jie(境界)” is a supplem...

Octahedral tilt relaxation decoupled from lattice parameters in epitaxial perovskite oxide films

Epitaxial strain in perovskite oxide thin films is conventionally understood through lattice parameter modulation, characterized by the c / a ratio of the pseudocubic cell. However, internal atomic arrangements such as octahedral tilting can relax independently, a phenomenon that...

Three cases of Dravet syndrome with electrical status epilepticus in sleep: Case reports

Background Interictal electroencephalography (EEG) findings in Dravet syndrome (DS) evolve with age. EEG is typically normal during early infancy; however, various abnormalities may later emerge, including generalized spike-and-wave activity. Nevertheless, cases of DS associated...

Transmembrane PhoxID: photoproximity labelling across the plasma membrane in vivo

Transmembrane proteins perform essential roles in cellular transport, signalling, and communication. The function and dynamics of these proteins are precisely regulated by interactions on both sides of the plasma membrane; thus, mapping the composition of these interactomes is a...

Hydrodynamics substantially affects induced structure formation in magnetic fluids

Magnetorheological fluids consist of micrometer-sized magnetic particles in a carrier liquid. Sufficiently strong external magnetic fields lead to the formation of string-like particle aggregates. We demonstrate that hydrodynamic interactions, that is, mutual couplings via induce...

Design of a novel hybrid advanced adiabatic compressed air and gravity energy storage system

Abstract To enhance the energy efficiency and energy density of physical energy storage (PES) systems, this study introduces a novel hybrid advanced adiabatic compressed air and gravity energy storage (HAACAGES) system. This system integrates advanced adiabatic compressed air ene...

Pediatric health events during disaster response: a multi-disaster analysis of emergency medical team records in Japan, 2016–2020

Children are particularly vulnerable during disasters; however, comprehensive data on pediatric health events across multiple disasters are lacking. This study aimed to characterize the health events affecting children during disaster response using disaster medical records from...

Flowering Plant Species Differ in Their Suitability for Orius strigicollis (Poppius): Effects on Plant Preference, Longevity and Oviposition Under Laboratory Conditions

ABSTRACT Flowering plant species can support pest control by providing resources for natural enemies. Polyphagous predatory species of the genus Orius occur in many parts of the world and are widely used as biological control agents. They feed on several common pest species and c...

Towards responsible AI in workplace-based assessment: a scoping review using Downing’s framework

This scoping review maps generative AI applications in workplace-based assessment (WBA) and analyzes validity evidence through Downing’s framework. Following JBI methodology and PRISMA-ScR guidelines, four databases were searched (2022-February 2026) with dual-AI screening and hu...

Cesarean delivery and overweight at 6 years of age: a prospective cohort analysis of the Japan Environment and Children’s Study

Abstract Cesarean delivery (CD) has been suggested as a potential risk factor for childhood overweight and obesity; however, evidence beyond early childhood remains inconsistent. We examined the association between CD and childhood overweight at age 6 years and explored early lif...

Universal Mass-Gap Formula ∆ = μ ln K: Exact Spectral-Chaos Scaling and Hadron Spectroscopy

We propose a universal logarithmic scaling law for excitation gaps, ∆a(K) = μa ln K, where K ≥ 2 is the integer branch degree of exactly solvable chaos and μa is a sector-dependent physical calibra- tion scale. The mathematical origin of the logarithm is the exact regularity-reso...