King's College London

Access in all areas? A round-up of developments in market access and health technology assessment: part 16

In this update we review new evidence on the rising prevalence of prior authorization rejections, delays and denials affecting US patients seeking access to branded prescription medications. We also examine a comparative study of cost-effectiveness thresholds cited in the USA and...

Large-Scale Open Science Simulated Data to Study the Development of Brain and Behavior Relationships: Epidemiologic, Clinical, and Neuroimaging Characteristics

Both brain and behavior undergo considerable changes during adolescence, a time synonymous with the emergence several psychiatric disorders, including mood and psychotic disorders. Multiple studies have explored the interaction between brain and behavior during childhood and adol...

A liquid handling platform for standardised quantification of cell-free enzymatic activity encoded by antimicrobial resistance genes

ABSTRACT Antimicrobial resistance (AMR) is a growing global threat to human health, and rapid methods for characterising emerging antimicrobial resistance genes (ARGs) are needed. Here, we develop a semi-automated workflow using cell-free gene expression (CFE) systems to measure...

Deep learning super-resolution of paediatric ultra-low-field MRI without paired high-field scans

ABSTRACT Brain magnetic resonance imaging (MRI) is essential for diagnosis and neurodevelopmental research, but the high cost and infrastructure demands of high-field MRI limit its use to high-income settings. Ultra-low-field MRI scanners offer a more affordable and energy-effici...

Uniqueness problem for accretive Schrödinger operators with complex singular coefficients

Abstract This paper studies the uniqueness problem for the one‐dimensional Schrödinger operator associated with the formal differential expression in the complex Hilbert space . The coefficients of the expression are complex‐valued and satisfy where the derivative is understood i...

Shifting drivers and predictable corridors of an illegal wildlife trade network

Illegal wildlife trade is a major driver of biodiversity loss but the lack of understanding of mechanisms sustaining criminal networks hampers law enforcement. We integrated three decades of confiscation data, criminological modeling, and spatial network analysis to dissect the i...

Estimating differing causal roles of glutamate and GABA genes on brain and behavior in autism

Abstract The excitatory/inhibitory (E/I) imbalance theory suggests that excitatory and inhibitory alterations underlies autism characteristics. However, genetic underpinnings of this imbalance and its impact on brain function and behavior remains unclear. We explored causal links...

Identification of a novel small-molecule modulator targeting SNX10 to inhibit osteoclastic bone resorption

Current antiresorptive therapies reduce bone loss by eliminating osteoclasts or inhibiting their formation. However, these approaches could disrupt osteoclast-osteoblast communication and cause serious complications with long-term usage. There is a need for developing new therapi...

Beyond Surface Catalysis: Dynamic Cation‐Regulated Interfacial Water Gating for Aqueous Polysulfide Electrochemistry

ABSTRACT Aqueous sulfur electrochemistry holds great promise for high‐energy density storage but is currently constrained by sluggish redox kinetics and severe polarization. Despite extensive efforts in catalyst design to enhance polysulfide adsorption, kinetic improvements have...

Gender Bias in Clinical Diagnosis of Borderline Personality Disorder and Autism Spectrum Disorder: A Retrospective Cohort Study

Background: Autism spectrum disorder (ASD) and borderline personality disorder (BPD) share overlapping clinical features including social cognitive differences, interpersonal difficulties, emotional dysregulation, and alexithymia. The two conditions show different gender prevalen...

Reducing Emotional Burden Carried by Neurodivergent Students in School: Perspectives From Students and School Staff

Abstract Purpose Compared to neurotypical peers, neurodivergent students experience increased exposure and more intense responses to commonly upsetting events (emotional burden), contributing to poor mental health. Student and staff perspectives offer insights into sources of emo...

Dosimetry and immunohistochemistry study to establish radiolabelled prostate-specific membrane antigen (PSMA) as a potential theranostic target in high-grade glioma treatment

Abstract Prostate-specific membrane antigen (PSMA) is upregulated in high-grade glioma (HGG). This study aimed, firstly, to establish dosimetry for the radionuclide [68Ga]-PSMA-11 in HGG patients; secondly, to determine theoretical tumour doses for [177Lu]-PSMA, a potential thera...

Inclusive designs that allow the inclusion of a broader population in randomized controlled trials: An evaluation of randomization ratio and analysis strategy

In most multi-arm randomized controlled trials, all participants need to be eligible to be randomized to all the arms. This means some participants are excluded from participating in multi-arm studies. We propose to relax this by considering a 'differential randomization' approac...

Universal modular properties of generalized Gibbs ensembles and chiral deformations

A bstract We study modular properties of conformal field theories perturbed by holomorphic fields. We prove an asymptotic formula for the modular S-transform of a generalized partition function that includes zero modes of higher spin holomorphic currents. The derivation makes use...

EFAU-Net: efficient feature-enhanced U-Net for early pregnancy ultrasound segmentation

Early-pregnancy ultrasound images often contain gestational sac, yolk sac, and embryo regions with blurred boundaries, variable shapes, and small target sizes, which makes accurate segmentation difficult. In addition, many existing segmentation networks have high computational co...

Selective Neuronal Vulnerability to Alpha-Synuclein Pathology in Parkinson’s Disease: A Critical Review of Mechanistic Rationale and Biomarker Stratification

Background: Parkinson’s disease (PD) exhibits remarkable clinical heterogeneity, with substantial variability in motor progression, cognitive decline, and the development of non-motor manifestations. Although the propagation of pathological alpha-synuclein is considered a central...

The long view: in conversation with the former editors of Journal of Cyber Policy

On 29 June 2026, the Editor-in-Chief, Tim Stevens, sat down with the Journal’s former editors, Emily Taylor and Joyce Hakmeh, to discuss the past, present and future of the Journal. Emily has been ...

Earthquakes and divergent economic recovery: case studies of Chile and New Zealand

Abstract The consequences of natural disasters, such as earthquakes, are evident: death, coordination problems, destruction of infrastructure, and displacement of the population. However, according to empirical research, the impact of a natural disaster on economic activity is mi...

Strain-Specific Reduction of Ndel1 Enzymatic Activity During Early Zika Virus Infection in the Neonatal Brain

Zika virus (ZIKV) infection during early development is associated with severe neurodevelopmental impairment, including congenital microcephaly, yet the molecular mechanisms linking viral exposure to neuronal dysfunction remain incompletely understood. Ndel1 (nudE neurodevelopmen...

Labeling of PET and PP nanoplastic test materials with non-leachable π-conjugated fluorescent polymers

<title>Abstract</title> Micro- and nanoplastic (MNP) particles are widely present in nature, mainly due to the extensive overuse of single-use plastics combined with poor waste management. Despite the diversity in the environment, many experimental studies still rely almost exclu...