Istanbul University

Structural and functional impact of lingual frenulum alterations on oral and craniofacial development in children during the mixed dentition stage

The clinical relevance of ankyloglossia in children remains controversial, largely due to the absence of standardized diagnostic criteria and the predominant reliance on morphological assessment. Evidence linking the combined anatomical and functional characteristics of the lingu...

The Limit of Halal Logistics Standards and the Need for "Halal Customs Clearance": Qualitative Evidence from Turkish Foreign Trade Processes

This study examines the customs clearance stage, which has remained largely outside the analytical scope of halal logistics literature that predominantly focuses on transportation and storage activities. Drawing on qualitative data obtained through semi-structured interviews with...

How appropriate are ChatGPT-5’s answers to acne questions?

Online conversational tools have become increasingly common sources of health information, with many patients seeking acne advice through such platforms. Although they may enhance awareness and encourage early consultation, their medical reliability remains uncertain. Because acn...

Reticulated Ferrocene−Polycarbazole Nanofibers Coupled with CuAl-LDH for Ultrasensitive Label-Free Electrochemical Detection of CA125

Abstract The development of highly sensitive and reliable sensing platforms for ovarian cancer biomarkers is of considerable importance for improving the early diagnostic performance and supporting clinical decision-making. Cancer antigen 125 (CA125) is among the most critical tu...

Automated lung tumor segmentation using enhanced U-Net architectures: a multi-backbone comparative study for clinical applications

Lung cancer remains a leading cause of cancer-related mortality worldwide, and manual delineation of tumors on computed tomography (CT) is time-consuming and prone to inter-observer variability. This study systematically evaluates nine deep learning configurations for automated l...

Beyond aerobic intensity: Comparing the effects of cognitively engaging gross-motor coordination training and aerobic exercise on working memory and selective attention in school-age children: A randomized controlled trial

Working memory and selective attention develop rapidly during middle childhood and are sensitive to physical activity. Aerobic exercise is thought to act mainly through intensity-driven physiological pathways (cerebral perfusion, neurotrophic signalling and arousal), whereas gros...

Simultaneous Reconstruction of Early Orbital Implant Exposure and Lower Eyelid Symblepharon Using an Oral Mucosal Membrane Graft Following Evisceration

A 72-year-old male patient presented with early orbital implant exposure and lower eyelid symblepharon after evisceration surgery performed at an outside center after severe ocular penetrating trauma. A single-stage reconstruction was performed. After release of the lower eyelid...

Beyond corneal structure in Noonan syndrome: topographic, tomographic, and optical findings

Introduction This study aimed to evaluate corneal topographic, tomographic, and wavefront characteristics in individuals with Noonan syndrome (NS) and to compare these findings with those of healthy controls.Methods This prospective, case–control study included 18 patients with N...

Can preheated resin composite optimize bond strength and film thickness for indirect adhesive restorations?

Abstract Purpose Resin composite shows potential as a luting agent for indirect adhesive restorations, but its viability as an alternative to resin cement remains uncertain. This study aimed to evaluate the microtensile bond strength (µTBS) and film thickness of preheated resin c...

Synthesis, in vitro enzyme inhibitory and antioxidant activities of novel S -Alkylated indole-1,2,4-triazole acyl hydrazones targeting type 2 diabetes

Managing postprandial hyperglycemia and oxidative stress remains a major hurdle in type 2 diabetes treatment. To tackle this dual challenge, we synthesized a novel series of S-alkylated indole-1,2,4-triazole acyl hydrazones, evaluating their antidiabetic and antioxidant capacitie...

SLC7A6OS Founder Mutation: A Rare Cause of Progressive Myoclonus Epilepsy Dated to 1100 Years Ago

BACKGROUND: SLC7A6OS c.191A>G is a rare, autosomal recessive cause of progressive myoclonus epilepsy (PME). The c.191A>G variant, first discovered in two families from Türkiye and Portugal, was recently identified in three additional probands from the USA, all of Puerto Rican anc...

Adult Mixed Epithelial and Stromal Tumor of the Kidney Harbors Recurrent Whole Chromosome 12 Gain

Mixed epithelial and stromal tumor (MEST), including adult cystic nephroma (CN), is an uncommon benign renal neoplasm that mostly occurs in middle-aged women. To date, a comprehensive molecular genetic investigation of MEST and/or adult CN has not been performed. Fourteen archiva...

Strongmen and warmaking

This essay asks whether warmaking can discipline the contemporary strongman regimes, as Tilly's account of European state formation might suggest it once did absolutism. To probe this question, it briefly revisits two non-European cases: New Kingdom Ancient Egypt and Warring Stat...

Clinical Outcomes of Robotic and Laparoscopic Ileal Pouch–Anal Anastomosis in Ulcerative Colitis: A Retrospective Cohort from Two Tertiary Referral Centers

Background: Robotic platforms may facilitate the technically demanding pelvic and multiquadrant components of ileal pouch-anal anastomosis (IPAA), but comparative evidence remains limited. Methods: We retrospectively compared 90-day outcomes after robotic ( n = 36) and laparoscop...

Requirements for Sustainable Industrial Facilities: A Systematic Review and Traceable Evidence-Mapped Requirements Framework

Industrial facilities combine production-driven loads, large-span structures, specialised environmental control, safety constraints and frequent process reconfiguration, limiting the direct transfer of generic green-building criteria. This PRISMA 2020 systematic review identifies...

Fenugreek ( Trigonella foenum‐graecum L.) as a functional food associated with improved heat‐stress survival in Caenorhabditis elegans

Abstract BACKGROUND Fenugreek ( Trigonella foenum‐graecum L.) is widely consumed as a functional food across Mediterranean, Middle Eastern, and South Asian cultures and has long been valued in traditional diets for its health‐promoting properties. Although fenugreek contains dive...

In silico characterization of SAP55: insights into a predicted phytoplasmal M41-like metallopeptidase effector with potential eukaryotic host dual lipidation motifs

Abstract Phytoplasmas are cell wall-less, phloem-limited plant pathogenic bacteria that cause devastating agricultural losses globally. Although phytoplasma pathogenicity is driven by secreted effector proteins translocated via the Sec pathway, their identification and functional...

The Use of Phytoplankton Communities to Determine the Ecological Status of the Büyükçekmece Reservoir and Investigate Water Quality Problems

Objective: This study aimed to assess the ecological status of Büyükçekmece Reservoir, a major drinking water resource for Istanbul, by integrating phytoplankton community structure with trophic indices, nutrient dynamics, and multivariate analyses. Temporal patterns were also ev...

Rei Vindicatio’da Davalının Dava Konusu Eşya Üzerinde Yaptığı Masraflara İlişkin Hukuki İmkanları

Roma hukukunda haksız zilyede yöneltilen rei vindicatio’da, davalının belli şartlar altında eşya üzerinde yaptığı masraflara ilişkin taleplerde bulunabileceği kabul edilmiştir. Talep edilebilir masrafların belirlenmesinde, masrafların türlerine ilişkin temel bir ayrımdan yararlan...

When Transparency Is Not Enough: Judicial Reviewability of Automated Billing Decisions in EU Consumer Disputes

This paper examines what EU transparency obligations achieve in consumer disputes arising from automated billing systems. The problem is not a mere lack of information, but the legal usability of the information disclosed. The fundamental question is whether the automated outcome...