Institution
Istanbul University
Recent research
- Health & MedicineOpen access
Abstract Background Thymic carcinoma (TC) is a rare and aggressive malignancy with limited evidence guiding second-line treatment after prior systemic therapy. We evaluated real-world outcomes of second-line systemic therapy in a multicenter cohort. Methods Adults with unresectab...
- Health & MedicineOpen access
Background/Objectives: Drug resistance is a major challenge in cancer therapy, and mitochondria contribute to this process by controlling both metabolic adaptability and cell survival signaling. Mitophagy, the selective lysosomal removal of dysfunctional mitochondria, has been im...
- Health & MedicineOpen access
Background: Long-term post-disaster settings increase infectious disease risks, requiring adequate knowledge and risk awareness to promote protective behaviors. This study was conducted to investigate the relationships between infectious disease knowledge, risk awareness, and pro...
- Society & Economics
A GOVERNANCE-ORIENTED PROMPT ENGINEERING FRAMEWORK FOR AI-ASSISTED INTERNAL AUDITING
The diffusion of generative Artificial Intelligence (AI) across organizational environments is reshaping both the objects of internal audit and the tools auditors use during assurance work. Although prior research has discussed AI adoption in auditing and the risks associated wit...
- Physics & SpaceOpen access
THE UNIFIED FLUIDIC UNIVERSE (UFU) MODEL: A MECHANICAL PARADIGM FOR VECTORIAL FLOW COSMOLOGY
Contemporary physics relies heavily on field-theoretic approaches and the addition of adhocentities such as dark matter to explain macro-scale phenomena. This manuscriptintroduces the Unified Fluidic Universe (UFU) model, redefining cosmology through thelens of fluid mechanics. W...
- AI & ComputingOpen access
Recent Advances and Open Challenges in Mitigating Inference-Time Attacks on Large Language Models
The rapid integration of Large Language Models into high-stakes domains has elevated inference-time attacks into a primary security concern for production deployments. These attacks are adversarial techniques that exploit models exclusively through their input–output interface. T...
- Health & MedicineOpen access
Background: Candida auris (C. auris) has emerged as a multidrug-resistant fungal pathogen causing healthcare-associated outbreaks worldwide, particularly in intensive care units (ICUs). Its environmental persistence, multidrug resistance, and high mortality make it a major challe...
- BiologyOpen access
Background: Inclusive educational assessment requires tools that capture how learners with diverse cognitive profiles engage with tasks. This study examines whether a game-based, gaze-contingent eye-tracking task can generate relevant indicators for inclusive assessment of autist...
- BiologyOpen access
Thymotrinan is an immunomodulating tripeptide containing the Arg-Lys-Asp sequence.In this study, the structural, vibrational, and electronic properties, as well as the bioactivity of thymotrinan, have been thoroughly examined.The conformational preferences of thymotrinan were eva...
- Society & Economics
Reinforcement Learning in Eating Disorders: Clinical, Cognitive, and Metabolic Correlates
OBJECTIVE: Reinforcement learning has been implicated in eating disorders, but findings remain inconsistent. This study compared reinforcement learning performance in anorexia nervosa (AN), bulimia nervosa (BN), and healthy controls (HC) using the Probabilistic Reward Task (PRT),...
- Health & MedicineOpen access
PURPOSE: This study evaluated the validity of the color selection results obtained from digital cameras. MATERIALS AND METHODS: Four observers matched the colors of 30 extracted maxillary incisors under daylight conditions. Two different digital cameras, with 1.5- and 5.0-megapix...
- AI & ComputingOpen access
Abstract Identifying suitable regions for solar photovoltaic (PV) deployment is commonly addressed through GIS- and multi-criteria decision-making (MCDM)-based frameworks; however, criterion weights in such studies are often derived from expert judgement or purely statistical ass...
- Health & MedicineOpen access
To develop and validate machine learning models for predicting match outcomes in elite kickboxing based on technical-tactical performance indicators and to identify the key variables distinguishing winners from defeated athletes. Video analysis was conducted on 142 elite kickboxi...
- Health & MedicineOpen access
This study aimed to determine the predictors of 14th and 28th day mortality in Staphylococcus aureus bacteremia and to evaluate the risk factors of methicillin-resistant S. aureus (MRSA). Our study, designed as a single-center retrospective observational study, included adult pat...
- Health & MedicineOpen access
ACUTE NECROTISING PANCREATITIS CAUSED BY SODIUM VALPROATE: A CASE REPORT
Valproic acid (sodium valproate; VPA)-associated pancreatitis is an uncommon but potentially life-threatening adverse event, particularly in children. Although pancreatitis related to valproate therapy is reported more frequently in pediatric patients than in adults, necrotizing...
- Society & EconomicsOpen access
The transformation of global competition from a predominantly cost-based structure towards technological capability, innovation, sustainability, and brand value has expanded the meaning of “made in” labels beyond the mere identification of a product’s country of manufacture. Thes...
- AI & ComputingOpen access
GROUND-STATE NEGATIVITY OF TRUNCATED CONNES-VAN SUIJLEKOM FORMS FOR DIRICHLET L-FUNCTIONS.
The Connes-van Suijlekom (CvS) framework associates to a real distribution Don [0, L] a finite Galerkin matrix whose ground state encodes spectral data of an associated L-function. We construct the CvS kernel for real primitive Dirichlet characters $\chi_{D}$ D a fundamental disc...
- Society & EconomicsOpen access
The transformation of global competition from a predominantly cost-based structure towards technological capability, innovation, sustainability, and brand value has expanded the meaning of “made in” labels beyond the mere identification of a product’s country of manufacture. Thes...
- Society & EconomicsOpen access
Non-routine problems play a significant role in mathematics learning due to their potential to foster students’ reasoning, inquiry, and critical thinking skills. Students, however, often experience difficulties in solving these problems and may experience negative attitudes towar...
- BiologyOpen access
Background/Objectives: Benzimidazole and hydrazone scaffolds are widely investigated in anticancer drug discovery because of their structural versatility and capacity to interact with multiple cancer-related targets. This study aimed to synthesize a series of trifluoromethyl-subs...