Istanbul University

Durable complete response after a single cycle of pembrolizumab-based chemoimmunotherapy in metastatic squamous cell lung cancer: a case report

Squamous cell lung cancer (SqCLC) is an aggressive subtype of non-small cell lung cancer (NSCLC), frequently associated with distant metastases. Although immune checkpoint inhibitors improve survival, complete responses after a single cycle of pembrolizumab-based chemoimmunothera...

Common Food Emulsifiers Impair Epithelial Barrier Integrity and Trigger Pro‐Inflammatory Responses and IgE Production

The global rise in allergic and autoimmune diseases since the 1960s has been associated with environmental disruptions of epithelial barriers, particularly in the gastrointestinal tract. Among the implicated factors are food emulsifiers, which have become increasingly prevalent i...

Comparison of clinical and dermoscopical nail findings of rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and psoriasis: A prospective study

Psoriasis (PsO), psoriatic arthritis (PsA), rheumatoid arthritis (RA), and ankylosing spondylitis (AS) are chronic inflammatory disorders classified as immune-mediated inflammatory diseases (IMIDs). Although these diseases share common pathogenic mechanisms, they can affect diffe...

Patient-level topology-aware graph transformer for breast histopathology classification

Progress in computational pathology is limited not only by model architecture, but also by evaluation design. In breast histopathology benchmarks such as BreaKHis, multiple correlated image tiles often originate from the same patient; consequently, image-wise splits can inflate p...

Outcomes of living related kidney donors of recipients with familial mediterranean fever-associated Amyloid A Amyloidosis

BACKGROUND: Living kidney donation among carefully selected individuals is generally considered safe but post-donation health risks vary by factors including family history. Data on long-term outcomes of related living kidney donors of recipients with familial Mediterranean fever...

Greater Mediterranean Diet Adherence Is Associated with Lower Odds of Chronic Migraine: A Retrospective Observational Study

Background: Dietary factors may influence migraine burden, but the relationship between Mediterranean diet (MD) adherence and migraine chronicity remains unclear. This study aimed to investigate whether higher MD adherence is associated with a less severe migraine phenotype, part...

A Data-Driven Framework for Condition Monitoring and Early Warning of Low-Efficiency Events in Photovoltaic Systems

Reliable photovoltaic (PV) operation requires monitoring strategies that can detect performance degradation before it develops into persistent efficiency loss. This study proposes an interpretable data-driven framework for condition monitoring and early warning of low-efficiency...

Nonfermenting Gram-Negative Bacilli Other Than Pseudomonas and Acinetobacter Species in Pediatric Blood Cultures: A Multicenter European Analysis

BACKGROUND: Nonfermenting Gram-negative bacilli other than Pseudomonas and Acinetobacter species are increasingly recognized as opportunistic pathogens in pediatric populations, yet their epidemiology and antimicrobial resistance remain poorly defined. METHODS: We conducted a mul...

Beyond Traditional Continuous Performance Tests: The Incremental Diagnostic Value of Distractor-Embedded Paradigms

Objective Distractor-embedded continuous performance test (CPT) paradigms have been developed to enhance the ecological validity and diagnostic precision of attention-deficit/hyperactivity disorder (ADHD) assessment. This study aimed to quantitatively synthesize the diagnostic pe...

Blood Pressure and Angina-Related Health Status During Benidipine Therapy: A Multicenter Real-World Cohort Study

Background: Benidipine is a long-acting calcium channel blocker used for the treatment of hypertension and chronic coronary syndrome. Although it effectively lowers blood pressure (BP), the relationship between BP reduction and improvement in angina-related health status during b...

The Past, Present, and Future of Online Biodiversity Knowledge Systems

In recent decades, the availability and accessibility of biodiversity data and the profusion of portals, tools, and platforms through which to utilize them have increased rapidly. This reflects the extensive variety of challenges biodiversity data are being used to address and th...

A Telerehabilitation-Based Life Balance Training Program for People with Schizophrenia: A Pilot Study

This pilot study examined the preliminary effects of a telerehabilitation-based Life Balance Training (LBT) program on life balance and instrumental activities of daily living (IADL) in individuals with schizophrenia. Twelve adults with schizophrenia were allocated to an interven...

Impact of adjuvant endocrine therapy on disease-free survival in early triple-positive breast cancer: a multicenter retrospective cohort study of the Turkish oncology group

Triple-positive breast cancer (TPBC), characterized by concurrent ER, PR, and HER2 positivity, poses unique therapeutic challenges due to ER–HER2 crosstalk. The optimal adjuvant endocrine therapy in TPBC patients receiving anti-HER2 regimens remains poorly defined. This multicent...

Machine Learning-Based Sex Classification Using Linear Dimensions of the Talocrural Joint

Background: Pelvic and cranial markers are often fragmented in mass disasters. The resilient talocrural joint serves as a valuable secondary site. This study presents a novel 12-landmark configuration on conventional 2D AP ankle radiographs as a rapid, cost-effective auxiliary se...

Exploring Decisional Factors to Include Approaches in a Patient Decision Aid for Juvenile Idiopathic Arthritis Symptom Management

Objectives Youth with juvenile idiopathic arthritis (JIA) experience physical and mental health symptoms that negatively impact their participation in daily life activities. The JIA Option Map is a web-based patient decision aid (PDA) created to facilitate decision-making for JIA...

Beyond the Heritage Text: Arab Folklore as an Approach to Developing Linguistic and Cultural Competence in Teaching Arabic to Non-Native Speakers: The Intermediate Level as a Model

تمثل الثقافة مكوّنًا أساسيًا في تعليم اللغات؛ إذ لا يتحقق اكتساب اللغة بصورة متكاملة بمعزل عن سياقاتها الاجتماعية وقيمها ورموزها الثقافية. ويُعد الفلكلور العربي، ولا سيما الحكاية الشعبية، من المصادر الثرية القادرة على الجمع بين المحتوى اللغوي والثقافي في تجربة تعليمية واحدة. هدفت...

Exploring Training Needs to Facilitate Shared Decision Making in Juvenile Idiopathic Arthritis Symptom Management and the Use of the JIA Option Map

Objectives Our team developed the JIA Option Map, a web-based patient decision aid (PDA) designed to support shared decision-making (SDM) for juvenile idiopathic arthritis (JIA) symptom management. Since training for health care providers (HCP) can enhance SDM and the use of PDAs...