Istanbul University

Machine learning-assisted design of a novel crocin-loaded poloxamer 407/hyaluronic acid in situ forming hydrogel for endometriosis treatment: in vitro characterization and in vivo efficacy evaluation

Our study focused on fabricating and characterizing a crocin in situ forming hydrogel for endometriosis treatment. An artificial neural network (ANN)-based machine learning (ML) approach was employed to determine the effects of poloxamer 407 (P407) and hyaluronic acid (HA) concen...

Geleneksel Para ve Kripto Varlıklar Arasında İkame Dinamikleri: Bitcoin ve M2 Para Arzı Üzerine SVAR Analizi

Literatürde parasal ikame kavramı, ekonomik birimlerin portföy tercihlerinde yerli para yerine alternatif değer saklama ya da mübadele araçlarını tercih etmeleri şeklinde tanımlanmakta ve çoğunlukla enflasyon, finansal istikrarsızlık ile güven faktörleriyle ilişkilendirilmektedir...

Fresh-semen proAKAP4 concentration predicts sperm cryotolerance independently of conventional semen quality across three goat breeds

Abstract Cryopreservation compromises sperm quality, yet conventional semen analysis poorly predicts which ejaculates will withstand freezing. proAKAP4, a sperm-specific structural protein, is a candidate freezability biomarker, but is usually measured after thawing. We tested wh...

Effects of virtual reality-based aerobic exercise versus traditional aerobic exercise training on physical fitness, functional capacity, and quality of life in individuals with Down syndrome: DOWNFIT (Down Syndrome Fitness Intervention Trial) randomized controlled trial

Purpose To compare the effects of virtual reality-based aerobic exercise (VR-AE) and traditional aerobic exercise (TAE) on on physical fitness, functional capacity, and quality of life (QoL) in adolescents with Down syndrome (DS).Methods Forty adolescents with DS (mean age 14.45...

Cluster headache care gaps among primary healthcare physicians in the Middle East, North Africa, and Türkiye: a multinational study

Cluster headache is one of the most severely disabling primary headache disorders and is frequently associated with diagnostic delay, inappropriate treatment, disability, and substantial psychosocial burden. Because primary healthcare (PHC) physicians are commonly the first point...

Real-world outcomes of children with first relapsed acute lymphoblastic leukemia treated according to the ALL-IC REL 2016 guideline in Türkiye

Relapsed acute lymphoblastic leukemia (ALL) remains a major challenge in pediatric oncology, particularly where access to modern immunotherapies is limited. This national multicenter study evaluated real-world outcomes of children with first relapsed ALL treated according to the...

Calibrating Integrity Claims for Centrally Operated Records: An Optional-Scrutiny Design Model

A hash chain, a ledger database, or a transparency log makes a single-writer record checkable; what the operating institution may claim depends on who retained evidence, when, and how independently. This paper develops an optional-scrutiny assurance model for centrally operated i...

Composite Uric Acid Index for Prediction of Significant Coronary Stenosis on Computed Tomography Angiography

OBJECTIVE: A recently proposed uric acid index combining fasting glucose, triglycerides, and uric acid has shown promise in cardiovascular risk stratification. It was assessed whether the index could predict significant coronary artery stenosis (≥50%) on coronary computed tomogra...

Türk Atasözlerinde Kardeşlik Kavramı

Atasözleri uzun gözlem, deneyim ve yaşantılara dayanır. Onu üreten milletin evrene ve yaşama bakışını yansıtır ve kültüründen izler taşır. Öğüt verme amacını taşıyan felsefi ve hikmetli özlü sözler olan atasözleri, halka mal olmuştur. Mecazi ve metaforik anlamlara sahiptir. Şiirl...

Evaluation of the accuracy and reproducibility of large language models (ChatGPT, DeepSeek, Gemini) in responding to patient-centered lipedema questions

Background Lipedema is a frequently misdiagnosed chronic condition that significantly impacts patients’ quality of life. As artificial intelligence (AI)-based large language models (LLMs) become increasingly integrated into healthcare communication, their accuracy and consistency...

Do Free-Living Amoebae Serve as a Shelter for Helicobacter pylori in Istanbul’s Water Treatment Plants?

Understanding microbial survival mechanisms in aquatic environments is essential for public health. This study investigates the potential role of free-living amoebae (FLA) as environmental shelters for Helicobacter pylori in Istanbul’s potable and wastewater treatment plants. Sam...

Circadian Misalignment and Chrononutrition in Type 2 Diabetes: Mechanistic Insights and Translational Gaps

Circadian rhythms regulate glucose metabolism, insulin secretion, hepatic glucose production, peripheral insulin sensitivity, nutrient handling, and energy balance. Observational studies have associated circadian timing disruption through shift work, irregular sleep, artificial l...

Effect of education on oral antiviral use on medication adherence and quality of life in patients with chronic hepatitis B: a randomised trial

Background: Adherence to oral antiviral therapy is essential to reduce progression from chronic hepatitis B (CHB) to cirrhosis and hepatocellular carcinoma. Aim: To evaluate the effect of education on oral antiviral use on medication adherence and quality of life (QoL) in patient...

Assessing the Reliability of Micro-Doppler Spectrogram Classification from the DIAT-μSAT JPEG Archive

Reliable AI-assisted interpretation of radar-derived micro-Doppler images requires evaluation protocols that separate image-archive regularities from physical generalization. We audited 4849 DIAT-μSAT JPEG spectrograms and evaluated partition sensitivity, image controls, and repr...

Stroboscopic Versus Traditional Balance Training in Female Volleyball Players With Chronic Ankle Instability: A Randomized Controlled Trial

Background: Chronic ankle instability (CAI) causes recurrent sprains, reduced proprioception, and impaired postural control, negatively affecting volleyball performance. Stroboscopic glasses-based balance training can enhance sensorimotor control by manipulating visual input. Hyp...

Translating Mahr into Secular Categories: Turkish Civil Law and the Legal Characterization of an Islamic Institution

The Turkish Civil Code of 1926, received from Switzerland, established a secular family law resting on numerus clausus and a broadly mandatory structure; yet mahr, an institution of Islamic family law, has persisted in social practice and, since the binding unification-of-case-la...

Rare WDR19 Variants in Patients With Dental and Retinal Anomalies

Genetic variants in WDR19 cause ciliopathies with craniofacial and ectodermal features, including dental and retinal anomalies. This study characterized the clinical and molecular features of patients with isolated dental anomalies harboring WDR19 variants. Clinical and radiograp...

Time-dependent efficacy of tumor burden score in hepatocellular carcinoma treated with transarterial chemoembolization

Tumor Burden Score (TBS) is an emerging prognostic indicator for hepatocellular carcinoma (HCC). We aimed to evaluate the long-term prognostic efficacy, time-dependent discrimination, and treatment response associations of TBS in patients with HCC undergoing transarterial chemoem...

Miocene to Quaternary Tectonostratigraphic Evolution of the Northern Section of the Burdur‐Fethiye Shear Zone, South‐Western Türkiye

ABSTRACT The Burdur‐Fethiye Shear Zone (BFSZ) is a deformation zone accommodating strain partitioning between extensional and compressional domains in south‐western Türkiye. It exhibits a broad, linear geometry with a width of ~75–90 km and extends from Şuhut‐Çay to Sarıgerme‐Gel...

Association of Monocyte Subsets with Carotid Artery Stenosis Severity

Background and Objectives: This study aimed to investigate the association between circulating monocyte subset profiles and carotid artery stenosis (CAS) severity and to examine their relationships with inflammatory and atherosclerosis-related parameters. Materials and Methods: T...