Inserm

Questioning the Evidence for Host-Symbiont Codiversification in Mycorrhizal Symbioses

Abstract The vast majority of plants form mycorrhizal symbioses. The ecological importance of these mutualistic interactions has sparked interest in their long evolutionary history. By examining interaction networks and phylogenetic trees, several studies have suggested that plan...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...

Efficacy of rTMS in Post‐Stroke Bilingual Aphasia: A Single Case Experimental Design

BACKGROUND: The application of non-invasive brain stimulation in the rehabilitation of bilingual individuals with aphasia following a stroke is understudied. Recent studies show benefits of anodal cerebellar transcranial Direct Current Stimulation in bilinguals, while in monoling...

Critical neuronal avalanches arise from excitation-inhibition balanced spontaneous activity

Neuronal avalanches are sequences of neural activations exhibiting scale-invariant statistics, indicative of critical dynamics. Theoretical studies proposed that the balance between excitation (E) and inhibition (I), along with neuromodulation, are key factors influencing this cr...

A dendritic cell autophagy–neutrophil axis limits intratumoral STING immunotherapy

The cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway promotes tumor immunogenicity, but intratumoral STING agonists, despite strong preclinical efficacy, have shown limited clinical efficacy. The mechanisms restricting therapeutic STING activation rem...

DOPAL links dopamine dysregulation to neurodegeneration: a translational systematic review and meta-analysis

3,4-Dihydroxyphenylacetaldehyde (DOPAL) is the most reactive dopamine (DA)-derived aldehyde and has been implicated in selective dopaminergic neurodegeneration in α-synucleinopathies, including Parkinson’s disease (PD) and multiple system atrophy (MSA). Here, we present the first...

Macrophage heterogeneity in human secondary lymphoid organs

Abstract Macrophages play a major role in immune responses and in the maintenance of tissue homeostasis. Most of our knowledge of macrophage biology comes from mouse studies, which have revealed the existence of distinct subpopulations differing in origin, life cycle and tissue-s...

Conserved dimerization architecture in C‐type lectins from virus‐vector mosquitoes

Abstract C-type lectins (CTLs) play key roles in innate immunity and microbial carbohydrate recognition. In the disease vector mosquito Aedes aegypti , the CTLD-S family comprises 34 soluble CTLs whose members are implicated in flavivirus dissemination and microbial homeostasis,...

Seed-based functional connectivity of the anterior cingulate cortex and the posterior insula predicts placebo analgesia in Parkinson’s disease

Chronic pain affects up to 80% of people with Parkinson’s disease (PD) and remains difficult to treat. Functional brain connectivity can predict analgesic response in other conditions, but has not been explored in PD. To assess whether baseline resting-state functional connectivi...

Agreement of Hematologic Measurements Between Jugular and Coccygeal Puncture Sites in Cattle

ABSTRACT Background In bovine medicine, venipuncture is commonly performed at either the jugular or coccygeal vein. Although the coccygeal site is often preferred for practical reasons, sampling sites are inconsistently standardized in scientific studies. It is therefore importan...

Robot-Assisted Versus Open and Laparoscopic Radical Nephrectomy with Inferior Vena Cava Thrombectomy forRenal Cell Carcinoma: A Systematic Review and Meta-Analysis

Background/Objectives: To compare perioperative, pathological, functional, and oncological outcomes of robot-assisted radical nephrectomy with inferior vena cava tumor thrombectomy (RARN-TT) versus open (ORN-TT) and laparoscopic (LRN-TT) approaches. Methods: PubMed, Scopus, and W...

Effect of the WHO ICOPE prevention program on falls and mobility functions : a retrospective study in France

Abstract Background World Health Organization developed the Integrated Care for Older People (ICOPE) prevention program in order to promote the maintenance of intrinsic capacities for older adults, based on six key domains. Each key domain is a risk factor for falls in older adul...

Defining global priorities in hematopoietic transplantation and cellular therapy: a statement paper from EBMT Global ComMittee

Abstract Hematopoietic cell transplantation, cellular and gene therapies, and (CAR)-T cells have revolutionized outcomes in hematologic disorders. However, major disparities persist in their availability, accessibility, and affordability, particularly in low- and middle-income co...

Association between Pulmonary Vascular Obstruction Phenotype and Pulmonary Embolism Recurrence: Results from the PADIS-PE Study

Pulmonary vascular obstruction index (PVOI), assessed using the Qanadli index on computed tomography pulmonary angiography (CTPA) at pulmonary embolism (PE) diagnostic, has been associated with recurrence after unprovoked PE, but its complexity limits routine use. We aimed to eva...

Prospective analysis of pre-diagnostic untargeted plasma metabolomics and risk of triple-negative breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Triple-negative breast cancer (TNBC) accounts for 10–15% of newly diagnosed breast cancer, and its aetiology is poorly understood compared to other breast cancer subtypes. We applied untargeted metabolomics to identify novel biological pathways associated with TNBC risk and poten...

Long‐Term Outcomes of Continent Cutaneous Urinary Diversion in Patients With Neurogenic Lower Urinary Tract Dysfunction: A Monocentric Experience

PURPOSE: To evaluate long-term outcomes and quality of life after continent cutaneous urinary diversion (CCUD) in patients with neurogenic lower urinary tract dysfunction (NLUTD). MATERIALS AND METHODS: We conducted a retrospective, single-center study including all patients with...

Lost in Translation: Interprofessional Variability in Understanding Pro Re Nata (PRN) Prescribing in Geriatric Practice—A Prospective Observational Study

Background/Objectives: Medication safety is a critical concern in older adults due to age-related vulnerability, multimorbidity, and polypharmacy. Pro Re Nata (PRN, “as needed”) prescribing is common in geriatric care but may be interpreted inconsistently across healthcare profes...

Adrenaline Use and Request for Emergency Medical Assistance to Manage Food Anaphylaxis

Summary Adrenaline was rarely used, medical assistance being requested in two thirds of anaphylaxis cases. Medical assistance request was less frequent if milder or no cardiovascular anaphylaxis symptoms.

Mechanism of Autophagic Extracellular Vesicles Revealed

Recent work by Mao and colleagues identifies a distinct class of small extracellular vesicles, termed autophagic extracellular vesicles (AEVs), generated from amphisomes upon autophagy induction. In this commentary, we discuss how this study provides important mechanistic insight...

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...