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Venular-centered thrombo-inflammation drives microvascular failure after arterial recanalization in acute mesenteric ischemia

Abstract Background Acute mesenteric ischemia (AMI) remains associated with high mortality despite prompt revascularization, suggesting that downstream ischemia–reperfusion injury contributes to poor outcomes. However, the microvascular mechanisms underlying this process are not...

Quantification of absolute IgG concentration in bat sera

Abstract Bats are endowed with a remarkable capacity to withstand important pathogens through evolutionary adaptations in their immune systems. Antibodies are essential component of the adaptive immune response and serve as a crucial biomarker, indicating both present and past pa...

The Costs of Parkinson's Disease in Europe: Results of the Costs of Illness in Neurology Initiative

Abstract Background Parkinson's disease (PD) is the second most common neurodegenerative disease. It imposes substantial and growing burden on patients, families, and caregivers and reduces quality of life. The disability and care needs associated with PD carry economic ramificat...

Clinical Variability and Genotype‐Driven Outcomes in CHRND ‐Related Congenital Myasthenic Syndrome

BACKGROUND: Congenital myasthenic syndromes (CMS) caused by pathogenic variants in CHRND, encoding the δ-subunit of the nicotinic acetylcholine receptor (AChR), are rare, and data on genotype-phenotype correlations and long-term outcomes are limited. METHODS: We performed a retro...

Deep molecular profiling of lung neuroendocrine tumours and supra-carcinoids

BACKGROUND: Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. The current WHO classification, based on mitotic count and presence or absence of necrosis...

The importance of classifying central hypopneas: a call to action

Obstructive and central sleep apnea share pathophysiologic features and often coexist within individual patients. There is general agreement on the criteria for scoring obstructive and central apneas but less guidance and clarity on how and when to classify obstructive and centra...

Contribution of mechanical forces in multiciliated cell differentiation

Abstract Multiciliated cells, through the coordinated beating of motile cilia, are vital for moving fluids in the brain and mucus in the airways and in the reproductive organs. Their dysfunction leads to diseases, associated with chronic airway infections, subfertility and ventri...

Longitudinal alignments and syntheses of multimodal clinical data for personalized medicine with the PULSE framework

Multimodal models capable of imputing diverse data used in single-cell biology studies provide potential foundational opportunities in clinical practice. However, patient data uniquely comprise longitudinal mosaic measurements that reflect underlying physiological dynamics and ex...

SRF fusion oncogenes encode constitutively activated chimeric transcription factors in myoid soft tissue tumors

ABSTRACT SRF fusion genes drive the pathogenesis of muscle-related soft tissue tumors, including subsets of perivascular tumors, inflammatory myofibroblastic tumor, and rhabdomyosarcoma. SRF encodes Serum Response Factor, a well-characterized transcription factor that regulates m...

Miscompartmentalization of microbiota-derived TMAO is a reversible driver in autism spectrum disorder

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder. Unlike genetics and gut dysbiosis, ASD appears to be homogeneous when considering tryptophan metabolism. Following these findings, we found that ASD was associated with the miscompartmentalization of t...

High uptake and adherence to cervical cancer screening among older French women based on a midwife-led outreach strategy and vaginal self-sampling: results from the RIDECA study

The acceptability and effectiveness of the invitation strategies using self-sample devices for cervical cancer screening are critical before further implementation. In France, participation of older women in cervical cancer screening remains low, and studies evaluating outreach s...

A nationally representative One Health multi-pathogen serosurvey in Cambodia: study protocol for the RACSMEI mixed-methods study

Abstract Background Cambodia faces a high and complex burden of zoonotic, vector-borne, vaccine-preventable and environmentally transmitted infections, driven by intensive human–animal–environment interactions. However, nationally representative data integrating human, animal and...

CLEC-1 promotes early IFN response in cDC1s and favors immune dysregulation during sepsis in mice

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host immune response, characterized by both hyperinflammation and immunosuppression. Here, we show that the absence of the C-type lectin receptor CLEC-1—expressed particularly by lung cDC1s—improves mouse rec...

Huntingtin, signaling endosomes and neuronal survival in health and Huntington disease

The axonal transport of organelles mediates several functions throughout the lifespan of neurons. Over the past years, the role of endosomes, a specific type of trafficking organelle, has been extensively investigated for their increasing relevance during development, maturation...

The rod bipolar cell pathway contributes to surround responses in OFF retinal ganglion cells

Abstract Sensory neurons can be influenced by stimuli beyond their receptive field center, yet the mechanisms underlying this surround modulation remain poorly understood. In the retina, many OFF ganglion cells exhibit responses to ON stimulation outside their receptive field cen...

Sex of central neurons controls intestinal niche signalling to drive sex differences in stem cell activity and cancer susceptibility

Abstract Sex differences in cancers arising in non-reproductive organs are widespread. While sex hormones and the intrinsic sexual identity of cancer cells are well-established contributors, it is unknown whether other mechanisms are involved. Here, we reveal an unexpected source...

Distinct Molten‐Globule Conformations in an Interacting Protein Domain Resolved by 19 F NMR of Fluoroproline Residues

ABSTRACT Recently, the application of deep learning to structural data deposited in the Protein Data Bank has enabled the reliable and accurate prediction of 3D folded structures of proteins from their sequences. However, this approach is not applicable to highly dynamic proteins...

Efficacy and safety of fenfluramine in Dravet syndrome: The impact of patient clinical characteristics

Abstract Objective To assess the efficacy and safety of fenfluramine in patients with Dravet syndrome (DS) stratified by age, number of previously attempted antiseizure medications (ASMs), and SCN1A pathogenic variant status. Methods In this post hoc analysis, data from three ran...

Distinct Molten‐Globule Conformations in an Interacting Protein Domain Resolved by 19 F NMR of Fluoroproline Residues

ABSTRACT Recently, the application of deep learning to structural data deposited in the Protein Data Bank has enabled the reliable and accurate prediction of 3D folded structures of proteins from their sequences. However, this approach is not applicable to highly dynamic proteins...

Constitutive natural killer cell features associated with post-treatment control of SIV infection in the pVISCONTI study

Abstract Post-treatment HIV controllers (PTC) offer a unique opportunity to uncover the determinants of durable remission after antiretroviral therapy (ART) interruption. Here, using six PTC and six post-treatment non-controllers from the pVISCONTI study in cynomolgus macaques, w...