Inserm

Cardiolipin deficiency disrupts electron transport chain and drives steatohepatitis

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive disorder marked by lipid accumulation, leading to metabolic dysfunction-associated steatohepatitis (MASH). A key feature of the transition to MASH involves oxidative stress resulting from defects in...

Cost-utility study of cognitive-behavioural management of auditory hallucinations in schizophrenia: a study protocol

Abstract Background Auditory verbal hallucinations (AVHs) affect 60–80% of patients with schizophrenia, causing significant distress and functional impairment. Although cognitive-behavioural therapy (CBT) has been shown to reduce AVH-related distress and relapse risk, its use rem...

Measurement of binding antibodies to SARS-CoV-2 variants elicited by natural infection and COVID-19 vaccines in a sub-Saharan African population

Abstract Data on immune responses to COVID-19 vaccination in West and Central Africa remain limited, particularly with respect to antibody (Ab) binding across SARS-CoV-2 variants and for different types of vaccine platforms. We assessed anti-spike (anti-S) antibody binding to nin...

Calpain inhibition prevents high-glucose-induced autophagy blockade and mitochondrial fragmentation in endothelial cells and preserves vascular functions in diabetic mice

Endothelial dysfunction is a major contributor to diabetic vascular complications, yet the mechanisms linking hyperglycemia to impaired endothelial homeostasis remain insufficiently defined. This study identifies calpains as key regulators of endothelial autophagy and mitophagy u...

Shared Hyperphagia phenotypes and variable response to semaglutide in adults with neurodevelopmental obesity

Adults with neurodevelopmental disorders (NDD) are at high risk of developing obesity, yet systematic evaluations of their eating behavior profiles remain scarce. In this study, participants were adults with overweight or obesity associated with a genetically confirmed NDD with i...

Reflex seizures and epilepsy surgery: A network approach case‐based exploration

Abstract Context Reflex seizures (RS) are defined by their consistent provocation by specific stimuli, encompassing a broad range from elementary sensory inputs to complex cognitive tasks. While RS are often encountered in clinical practice, their surgical management remains spar...

Timing of PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation

BackgroundApproximately one half of patients undergoing transcatheter aortic-valve implantation (TAVI) have concomitant coronary artery disease. Although percutaneous coronary intervention (PCI) is often performed before TAVI, the preferred treatment strategy has not been establi...

The Probiotic Strain Hafnia Alvei HA4597 and Its Protein Extract Selectively Activate Membrane Digestive Enzymes of Intestinal Cells in Mice

Oral supplementation of the Hafnia alvei (H. alvei) HA4597 probiotic strain has been shown to reduce appetite, body weight and fat content in overweight humans and obese mice. However, it remains unknown if H. alvei may also influence the gut digestive function. Thus, in the pres...

LDL Cholesterol Lowering With Evolocumab Before Percutaneous Coronary Intervention for Acute Myocardial Infarction

Importance: Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibition is recommended as second- or third-line lipid-lowering therapy after myocardial infarction (MI), resulting in prolonged periods of inadequate low-density lipoprotein cholesterol (LDL-C) control. Whether...

Real-World Use of Adjuvant Nivolumab for Resected Stage III–IV Melanoma: 2-Year Analysis of AdjuMel

Following the positive findings of the phase 3 CheckMate 238 trial, adjuvant nivolumab has become a standard therapy in patients with completely resected stage III–IV melanoma. The prospective, ongoing AdjuMel study is evaluating the real-world use, effectiveness, and safety of a...

Oral health, oral follow-up and infectious risk management of rheumatoid arthritis patients on anti-TNF drugs: a survey of a French e-cohort

Abstract Background As periodontitis is a recognized risk factor for rheumatoid arthritis (RA), it should be adequately treated before the initiation of biologic disease-modifying antirheumatic drugs (bDMARDs), along with any concomitant acute oral infection. bDMARDs remains a co...

The identification of a PRKACA duplication at 19p13.12 in a female with PPNAD and thyroid carcinoma after a 20-year diagnostic journey

Abstract Rare pathogenic variants affecting components of the evolutionary conserved cAMP/protein kinase A (PKA) signalling pathway are implicated in a spectrum of adrenocortical disorders. Germline inactivating PRKAR1A variants leading to constitutive PKA activation, underlie pr...

Evaluating the Validity of Model Organisms: A Review and a New Framework for Biologists

Model organisms are central to biological research. Living organisms are models in the sense that the knowledge gained from their study is meant to be generalized. For example, experiments conducted on Drosophila or nematodes bring general knowledge on phenomena such as cell migr...

FastCNV: fast and accurate copy number variation prediction from high-definition spatial transcriptomics and scRNA-seq data

Abstract Background Predicting DNA copy number variations (CNVs) from spatial transcriptomics (ST), including Visium HD, or single-cell RNA-sequencing (scRNA-seq) data helps to distinguish malignant from non-malignant cells and to characterize the clonal architecture of tumor cel...

Cancer in systemic sclerosis: clinical associations and prognostic impact from the EUSTAR registry

BACKGROUND: Cancer represents a major cause of mortality in systemic sclerosis (SSc). Established risk factors are limited to specific subsets, particularly early diffuse anti-RNA polymerase III (POLR3)-positive disease, needing further exploration. METHODS: We performed a nested...

A survey among geriatricians on geriatric oncology and geriatric surgical oncology models in Europe

Abstract Purpose To provide an up-to-date overview of geriatricians’ involvement in oncological and onco-surgical care for older adults across Europe. Methods An anonymous 35-item online survey was distributed via (inter)national societies between 10 April and 23 May 2025. The re...

Five Years of HCV Dried Blood Spot Testing in At‐Risk Populations and the Impact of Reduced Sensitivity on Missed Diagnoses

BACKGROUND & AIMS: Achieving HCV elimination requires diagnostic strategies capable of reaching underserved populations who remain poorly accessed by conventional healthcare pathways. Dried blood spot (DBS) sampling enables decentralised testing, but concerns remain regarding its...

Death determination at the bedside: clinical judgement beyond criteria

In clinical practice, death determination—a core responsibility of critical care clinicians—is commonly taught as the technical application of standardized medical and legal criteria. However, contemporary practices, including resuscitation, death determination by neurological cr...

Gut virome instability in HSCT

The gut virome remains one of the least resolved components of the human microbiome, limiting interpretation of how viral communities shape intestinal injury and recovery. Hematopoietic stem cell transplantation (HSCT), particularly in the allogeneic setting, offers an informativ...

Establishing a Prognosis When Identifying Pathogenic Variants in Usher Syndrome/ DFNB ‐Related Genes: An Impossible Challenge?

As our results show that very few published variants could currently be considered causative of DFNB due to lack of precise clinical studies, strict and uniform criteria should be applied by authors publishing on USH/DFNB genes.