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Human-inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity

Abstract We previously reported inherited RORγT deficiency in seven patients from three ancestries (Chilean, Palestinian, Saudi Arabian) with mycobacterial disease and chronic mucocutaneous candidiasis (CMC). We report here five additional patients from different ancestries (Afgh...

Coupling between statistical learning and interference suppression

Abstract In an ever-changing environment, synchronizing automatic and controlled behaviors is essential for successful adaptation. Yet, the relationship between these behaviors is often debated, partly because of the diverse approaches used to investigate them. The present study...

Patient and parent voices in tetralogy of Fallot: A French social media analysis

AIMS: To analyse French-language public online conversations about tetralogy of Fallot (TOF), with emphasis on patient and parent concerns, emotional tone, and information needs relevant to congenital cardiovascular care. METHODS AND RESULTS: We conducted a retrospective observat...

Morphology-Based Surgery for Chronic Pancreatitis Across Europe: Toward the Next Generation of Unified Guidelines

OBJECTIVE: To evaluate the use and impact of current surgical guidelines for chronic pancreatitis (CP) across Europe. SUMMARY BACKGROUND DATA: Current guidelines recommend morphology-based surgery for CP, but international studies evaluating their use and impact are lacking. METH...

Hippocampal volume changes in astronauts and bilateral vestibulopathy patients

Abstract The hippocampus is a particularly plastic and vulnerable brain structure. Given the modulatory role of the vestibular system on hippocampal function, we hypothesized that altered vestibular stimulation associated with prolonged spaceflight could lead to similar hippocamp...

Pattern-Anchored Diagnosis of Oral Epithelial Dysplasia: A Position Paper From COST Action INTERCEPTOR Working Group 2

Abstract Purpose Oral epithelial dysplasia (OED) is the principal histopathological marker for malignant risk stratification in oral potentially malignant disorders (OPMDs). Current World Health Organisation (WHO) three-tier and other binary grading systems are limited by modest...

Widespread circulation of West Nile and Usutu viruses in sedentary and migratory avifauna: A two-year study (2024–2025) of active surveillance in South of France

Abstract West Nile virus (WNV) and Usutu virus (USUV) are neurotropic Orthoflaviviruses sharing a similar enzootic transmission cycle primarily involving Culex pipiens mosquitoes as vectors and birds as amplifying hosts. First identified in Africa, both viruses established endemi...

Understanding rhythmic behavior in infancy: Perspectives for addressing developmental, methodological, and analytical challenges

Neural sensitivity to rhythm emerges prenatally, yet observable movement synchronization to an external beat occurs later and more gradually over development. Integrating findings from developmental psychology, neuroscience, music cognition, and social interaction research, we pr...

Burnout syndrome, sleep quality and the effect of the practice of physical activities among community pharmacists in Douala, Cameroon: a cross-sectional study

Abstract Background Burnout is a human psychological response to work stress, evolving more prevalent among healthcare professionals and associated with many contributing factors. Aim The present study aimed to determine burnout prevalence and its associations with physical activ...

NucGen3D: A synthetic framework for large-scale 3D nuclear segmentation with open-source training data and models

A bstract Robust nuclear segmentation in 3D microscopy images is a critical yet unresolved challenge in quantitative cell biology, hindered by the scarcity and variability of annotated volumetric datasets. Because such data are difficult to obtain, most state-of-the-art approache...

Evaluation of Disease Severity Using CSF Biomarkers in Patients With Probable Cerebral Amyloid Angiopathy

Cerebral amyloid angiopathy (CAA) is currently diagnosed using MRI-based Boston criteria. However, imaging markers represent downstream consequences of vascular injury and may not fully reflect disease severity. CSF biomarkers, particularly β-amyloid 1–42 (Aβ42) and β-amyloid 1–4...

Improving diabetes management in older adults with cancer: a quality improvement project to enhance monitoring during steroid-based systemic anti-cancer therapy

PURPOSE: Older adults undergoing systemic anti-cancer therapy (SACT) with steroids are at high risk of developing steroid-induced hyperglycaemia (SIH). However, monitoring and management remain inconsistent. This quality improvement project (QIP) involved developing and evaluatin...

Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism

Abstract Human reward processing varies along cue-centric and outcome-centric axes, but a reproducible mechanistic account of individual variation in incentive salience attribution has been lacking. Using fMRI across five cohorts (N-total=1,251; N1=890; N2=245; N3=34; N4=48; N5=3...

Longitudinal evidence for decreasing statistical learning abilities across childhood

Abstract Statistical learning enables us to identify patterns in our environment and predict future events, thereby supporting a range of motor, cognitive, and linguistic skills. Despite its significance, the developmental trajectory of statistical learning has remained unclear d...

Sensory plasticity of dorsal horn silent neurons as a critical mechanism for neuropathic pain

The spinal cord dorsal horn (DH) integrates sensory processing but undergoes critical plasticity following nerve injury, leading to mechanical allodynia, or “touch-evoked pain”. It has been proposed that after nerve injury, innocuous sensory neurons gain access to nociceptive-spe...

From fluid loss to calcification: MRI and CT matrix features in cystic echinococcosis

Abstract Objective To characterize MRI matrix signal and CT calcification patterns across WHO-IWGE stages, compare them with lesion mimicking cystic echinococcosis (CE), and derive an MRI-based subclassification for inactive cysts. Materials and methods This retrospective multice...

Frequency and laminar profile of feature-specific visual activity revealed by interleaved EEG–fMRI

Abstract The role of cortical oscillations in brain function has been extensively debated, resulting in a variety of theoretical frameworks. Using inter-leaved simultaneous EEG-fMRI, we examined the layer-specific relationship between oscillatory activity and visual processing. W...

Early mechanical changes of limb muscle in septic shock assessed by dual-plane shear-wave elastography

Abstract Background Septic shock induces skeletal muscle wasting and neuromuscular dysfunction, contributing to ICU-acquired weakness (ICUAW) and poor recovery after critical illness. Conventional ultrasound primarily captures structural changes but provides limited insight into...

Towards a deep-learning genomic tool for risk stratification and diagnostic support in sporadic ALS

Abstract Background A variety of common and rare genetic factors have been implicated in the development of amyotrophic lateral sclerosis (ALS), and the evidence is that a genetic component is present in most affected individuals. However, our current understanding of ALS genetic...

Classification of Seasonal Allergic Rhinitis Patients by Prospective Patient‐Recorded Symptoms: The @ IT .2020 Project

BACKGROUND: Seasonal allergic rhinitis (SAR) has been so far classified according to frequency and severity by retrospective information based on the ARIA (Allergic Rhinitis and its Impact on Asthma) classification. Electronic symptom diaries (e-Diaries) are feasible tools to col...