Humboldt-Universität zu Berlin

The core taxa connectivity in leaf microbiomes in ash trees stands is modulated by host-related and environmental factors

Abstract Background Forests cover large areas of the terrestrial land surface and play a key role in climate regulation and biodiversity conservation. Tree-associated microbial communities are integral components of forest ecosystems and contribute to plant functioning, stress to...

MOSAIC: Intra-tumoral heterogeneity characterization through large-scale spatial and cell-resolved multi-omics profiling

Understanding the tumor microenvironment has the potential to significantly advance precision oncology, but this effort has been hampered by the scarcity of consistent large data sets. Here, we introduce MOSAIC (Multi-Omics Spatial Atlas in Cancer), a multi-center clinical omics...

Pre-ECMO characteristics, organ dysfunction and exploratory mortality prediction in COVID-19 versus non-COVID-19 ARDS treated with veno-venous ECMO: a retrospective cohort study

Abstract Objective The transferability of pre-ECMO characteristics and established mortality prediction tools across COVID-19 (C-19) and non-COVID-19 (nC-19) acute respiratory distress syndrome (ARDS) remains uncertain. We compared clinical characteristics, organ dysfunction, res...

The future of scholarly blogs: Scholarly bloggers' perspectives on long‐term preservation

Abstract Scholarly blogs are an important venue for scholarly communication; however, they are not yet integrated into the preservation workflows of digital research and information infrastructures, which places their long‐term access at risk. By using Star and Ruhleder's (1996)...

What Works Against Populist Rhetoric? The Effects of Counter-Arguments on Democratic Attitudes

Abstract Politicians use populist rhetoric – arguments that portray politics as an enduring conflict between “the good people” and “the evil elites” – to generate support for attacks on constitutional safeguards, the media, and minorities. Yet, little is known about how to counte...

Nutrition and health status in the follow-up of the risks and benefits of a vegan diet (RBVD) study

Abstract To examine health risks and benefits of a vegan diet, the RBVD study was conducted in 2017 and followed up in 2021. The present paper evaluated dietary nutrient intake and status together with systemic cardiometabolic health-related biomarkers and examinations among vega...

Adoption of, attitudes towards, and perceived challenges of digital health in hospice and palliative care among professionals in Germany: a national cross-sectional web-based survey

Abstract Background Digital health technologies may support communication, symptom management, continuity of care, and access to services in hospice and palliative care. National data on their adoption, on professionals’ attitudes, and on perceived barriers are scarce. We examine...

Development and Nationwide Multicentre Evaluation of Guideline-Grounded Large Language Model Chatbots to Support Patient Self-Management and Education in Rheumatology

Patients with rheumatic diseases have persistent information needs that are not fully addressed in routine care. We developed and evaluated guideline-grounded, large language model (LLM) chatbots to support patient self-management and education in rheumatology.Ten disease-specifi...

Acceptance and commitment therapy for schizophrenia and psychosis inpatients with recovery and experience orientation ( ASPIRE ): A qualitative study of participant experiences

Abstract Objectives This uncontrolled study aims to gather a comprehensive understanding of participants' experiences during an inpatient intervention specialized in the treatment of psychotic disorders, embedded in a holistic therapeutic ward‐concept rooted in acceptance and com...

Green practices and perceived cost pressures in pork retailing: evidence from Northern Portugal

Purpose This paper examines whether environmental management practices in pork retailing, proxied by the monitoring of water, energy and waste indicators, are associated with retailers' perceived cost pressures in Northern Portugal. Design/methodology/approach Primary data were c...

Should I drink water or wine? Impacts of online nutritional counseling on the alcohol consumption of elderly individuals with mild cognitive impairment

Abstract Background People with mild cognitive impairment (MCI) have an increased health risk when they consume alcohol in comparison with people without cognitive impairment. Excessive alcohol consumption is an established modifiable risk factor that contributes to the risk of d...

Proteome signatures in ICU patients with COVID-19 and acute brain dysfunction: an observational cohort study

Abstract Deep sedation and delirium are common in COVID-19 intensive care unit (ICU) patients. Biomarkers for prediction, detection, and monitoring are missing. Unbiased omics analyses are warranted to gain a systems biology view on pathophysiology. This prospective observational...

A multimodal manual therapy, exercise, and psychological intervention for painful diabetic neuropathy: the NeuOst feasibility randomised controlled trial.

Introduction: People with painful diabetic neuropathy lack effective and tolerable treatments. Physical and psychological interventions may help but require further study and combination to maximise effects. Objectives: This single-site, 3-arm, parallel, randomised feasibility tr...

II. Chronologies

Abstract Despite a recent shift towards Global South-centred histories of development, women in and from Asia and Africa remain largely neglected in the historiography. In response, this Arenas issue examines the implications of situating the roles and experiences of women at the...

Mediating effect of pro-inflammatory cytokines in the association between depression, anxiety, and cardiometabolic disorders in a multiethnic US population

Abstract Neuroinflammation is associated with depression and anxiety risk, both of which demonstrate a bilateral relationship with cardiometabolic disorders. Systemic inflammation was also commonly described in patients with cardiometabolic disorders. It is, thus, unclear whether...

Optimal Velocity Control of a Brinkman–Cahn–Hilliard System with Curvature Effects

Abstract We address an optimal control problem governed by a system coupling a Brinkman-type momentum equation for the velocity field with a sixth-order Cahn–Hilliard equation for the phase variable, incorporating curvature effects in the free energy. The control acts as a distri...

Comparison Between Skeletally‐Anchored and Conventional Maxillary Protraction in Growing Class ΙΙΙ Patients: A Systematic Review and Meta‐Analysis

ABSTRACT Objective The aim of this systematic review was to evaluate the skeletal and dental effects of skeletally‐anchored (SA) maxillary protraction compared with conventional facemask (FM) therapy in growing patients with Class III malocclusion, while controlling for the confo...

Orpheus reimagined: an exploratory study on the impact of augmented reality on experiencing classical music in a live concert

Abstract This exploratory study investigates how virtual reality (VR) reshapes the experience of live classical music concerts. In a within-subject field experiment embedded in a concert series ( Orpheus reimagined ), 125 participants attended two performances of the same musical...

Cortex-wide laminar dynamics diverge during learning

Learning to link sensory information to motor actions requires coordinated activity across the cerebral cortex, but how different cortical layers contribute to learning remains unclear. Here we show that learning engages distinct, layer-specific activity patterns across the corte...

From Diagnosis to Long-Term Survivorship: A Scoping Review of Specialist or Advanced Nursing Roles in Gynecologic Oncology

OBJECTIVES: Due to rising survival rates in gynecologic cancers, the need for holistic, patient-centered, and multidisciplinary survivorship care is increasing. Evolving specialist or advanced nursing roles can help to improve quality of life within the interprofessional care tea...