Humboldt-Universität zu Berlin

TASA: A Tick-Based Affective State Architecture for Persistent, Inspectable Inner State – Framework, Learnability Conditions, Governance, and Evaluation

Standard language-model inference lacks cross-exchange internal organization. External memory can reconstruct continuity without persistent state whose causal role is tested. We present TASA (Tick-Based Affective State Architecture), a theoretical framework for such a state: segm...

Topogram-based anatomical labelling of CT series: anatomy-aware CT data processing using deep learning

Abstract Objectives This study provides a Rapid Analysis and Processing of Image Data (RAPID) framework that combines deep learning-based CT topogram analysis with DICOM spatial geometry to enable reliable anatomical labelling of CT series independent of inconsistent textual meta...

Functional metatranscriptomics of the rhizosphere: Towards an understanding of metabolic processes of the microbial carbon pump

Abstract The soil microbiome drives soil organic carbon (SOC) transformation, shaped and impacted by plant growth stage and soil management such as tillage. The soil microbial carbon pump conceptually links the degradation of plant- and microbe-derived compounds and the neosynthe...

Sea Level Emulator Intercomparison Project (SLEIP) Phase 1: Assessing emulated multi-century global mean sea level projections

Abstract. Simplified sea level modelling approaches calibrated against reference data, also referred to as sea level emulators, can explore future sea level rise and associated uncertainties with low computational cost. Here, we introduce the Sea Level Emulator Intercomparison Pr...

Old and New Schrödinger Eigenvalue Localization

Abstract. Unconditional guaranteed lower and upper eigenvalue bounds are mandatory for the understanding of the Schrödinger eigenvalue spectrum and its spectral gaps. While upper eigenvalue bounds are naturally induced by conforming discretizations, guaranteed lower eigenvalue bo...

Ischemic strokes as an initial manifestation of eosinophilic granulomatosis with polyangiitis with eosinophilic myocarditis: a case report

Abstract Background Eosinophilic myocarditis (EM) is a rare form of myocarditis which may be caused by eosinophilic granulomatosis with polyangiitis (EGPA), a rare disease which frequently affects the heart. The case of a young woman with a rare initial manifestation of EGPA as a...

Chronic exposure to aflatoxin B1, ochratoxin A, and citrinin in women and children and associated health risk characterization: blood biomonitoring evidence from rural Bangladesh

Abstract Dietary exposure to mycotoxins—including aflatoxins (AFs), ochratoxin A (OTA), and citrinin (CIT)—represents an important health risk, particularly in low-resource settings with widespread food contamination. This study investigates mycotoxin exposure among 712 participa...

Classification of Seasonal Allergic Rhinitis Patients by Prospective Patient‐Recorded Symptoms: The @ IT .2020 Project

BACKGROUND: Seasonal allergic rhinitis (SAR) has been so far classified according to frequency and severity by retrospective information based on the ARIA (Allergic Rhinitis and its Impact on Asthma) classification. Electronic symptom diaries (e-Diaries) are feasible tools to col...

Measurement Properties of Delirium Tools in Pediatric Intensive Care: A Systematic Review

CONTEXT: Delirium is common in pediatric intensive care units. Reliable tools are needed, but evidence on measurement properties remains fragmented. OBJECTIVES: To identify pediatric delirium tools and evaluate their measurement properties and certainty of evidence. DATA SOURCES:...

Social information quality and environmental volatility shape collective foraging behaviour

Abstract Collective foraging is widespread across the animal kingdom, allowing animals to more effectively discover resources. However, collective foragers need to balance a key trade-off between private exploration and using social information. Social information can come in ver...

The Molecular Architecture of Somatic Spines of the Lateral Septum

ABSTRACT The lateral septum is a key subcortical structure and has been implicated in social memory. One aspect of social memory, the ability to recognize relatives, is conserved across vertebrate species and reflected in stable, lifelong memories. Synapses are considered to be t...

Volumetric reference data of the orbit: a deep learning MRI analysis in the German national cohort

Abstract Manual segmentation of orbital magnetic resonance imaging (MRI) is labor-intensive, hindering large-scale morphometric studies. To overcome this, we developed a fully automated deep learning pipeline to segment orbital MRIs and establish age- and sex-stratified normative...

Programmed Death-Ligand 1 (PD-L1) expression and clinical outcomes in oral squamous cell carcinoma: evidence from a large clinical cohort

BACKGROUND: Despite the recognized biological relevance of the PD-1/PD-L1 axis in immune evasion, the prognostic significance of PD-L1 expression in surgically treated oral squamous cell cancer (OSCC) patients remains largely unclear. OBJECTIVE: To investigate the prognostic sign...

“I simply see it as our responsibility in the club business”: Key Stakeholder Perspectives on Setting-Based Harm Reduction Structures in Night Clubs in Berlin

Abstract Berlin’s techno party scene faces challenges of high alcohol and substance consumption associated with health and social issues, including intoxication and (sexual) violence. Recognising these challenges, the scene has evolved “Awareness Structures” (AS), on-site peer-le...

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activatio...

Prediction of Treatment Benefit With Internet-Based Cognitive Behavioral Therapy for Depression

Importance Treatment benefit prediction models may help identify which patients will benefit most from internet-based cognitive behavioral therapy (iCBT) for depression; it is unclear whether such models can support useful treatment allocation across programs. Objective To develo...

Tissue and Cerebral Biofluid Remodelling of tRNA-Derived Small RNA Signatures in Experimental and Human Epilepsy

Small noncoding RNAs are increasingly recognized as important regulators of gene expression in brain diseases including epilepsy. tRNA-derived small RNAs (tsRNAs) including tRNA fragments (tRFs) and tRNA halves (tiRNAs) are emerging as stable and regulated RNA species which respo...

Validation of the German Version of the Creative Imagination Scale (CIS) in Individuals with Mild to Moderate Depressive Symptoms: A Comparison with the HGSHS-5:G

Imaginative suggestibility is an important component of hypnotic responsiveness. However, a validated German version of the Creative Imagination Scale (CIS) is lacking. This study aimed to evaluate the psychometric properties and convergent validity of the German CIS against the...

Janus Reactivity of a Mononuclear Non‐Heme Iron(III)‐Peroxo Complex Toward Indole Oxidation

ABSTRACT Indole oxidation reaction is a pivotal process in organic chemistry, playing a crucial role in the synthesis of various natural products and pharmaceuticals. To‐date, indole oxidation is limited to heme enzymes and synthetic iron porphyrin compounds. Herein, we demonstra...

A Cournot–Nash model for a coupled hydrogen and electricity market

Abstract We present a novel model of a coupled hydrogen and electricity market on the intraday time scale, where hydrogen gas is used as a storage device for the electric grid. Electricity is produced by renewable energy sources or by extracting hydrogen from a pipeline that is s...