Humboldt-Universität zu Berlin

An additional water is introduced into the manganese cluster during the formation of the S3 state of photosystem II

During photosynthetic water oxidation, the Mn4Ca cluster in Photosystem II progresses through five intermediate Si (i = 0–4) states. X-ray crystallography studies have reported the insertion of one new O ligand during the formation of the S3 state, but recent studies question the...

Patient perspectives from the BEYOND Delphi panel: burden of remaining symptoms and their fluctuations, despite treatment, in patients with generalised myasthenia gravis

Abstract Background Patients with generalised myasthenia gravis (gMG) can experience remaining symptoms despite treatment. Our study aimed to describe how remaining symptoms and their fluctuations may affect a person’s daily life while living with gMG. Methods A modified-Delphi p...

An H-convergence-based implicit function theorem for homogenization of nonlinear non-smooth elliptic systems

Abstract We consider homogenization of semilinear elliptic PDE systems of the type $$ \partial _{x_i}\Big (a^{\alpha \beta }_{ij}(\varepsilon ,x) \partial _{x_j}u^\beta (x) +f_i^\alpha (x,u(x))\Big )=0 \text{ in } \Omega , \; \alpha =1,\ldots ,n, $$ ∂ x i ( a ij α β ( ε , x ) ∂ x...

Principal component analysis in Bayes spaces for sparsely sampled density functions

This paper presents a novel approach to functional principal component analysis (FPCA) in Bayes spaces, where densities are the object of analysis, but only few individual samples from each density are observed. We use the observed data directly to account for all sources of unce...

Evidence charts the future of freshwater biodiversity conservation

Evidence is essential for promoting freshwater conservation and selecting appropriate conservation actions. This article examines the importance of evidence for freshwater conservation, available sources, how evidence is used, geographical coverage, and the challenges in obtainin...

Western influence or local efforts? John Bernal and the Soviet organization of scientific information

Purpose This paper examines the relationship between John Desmond Bernal (1901–1971) and the Soviet approach to organize scientific information, focussing on the establishment of the All-Union Institute of Scientific and Technological Information (VINITI). Design/methodology/appr...

Implementing methane dynamics into the LPJmL6 model

Abstract. We extend the Dynamic Global Vegetation Model LPJmL to version 6.0 by explicitly representing methane (CH4) dynamics within the coupled carbon–nitrogen–water system. The implementation (i) prognoses water-table depth and wetland extent using a CTI–TOPMODEL framework, (i...

Empowering medical educators to teach planetary health: development and outcomes of a curriculum integration training

<title>Abstract</title> <bold>Background</bold> Planetary Health (PH) content is increasingly recognized as essential for medical education. For longitudinal integration across the curriculum, medical educators can serve as change agents and multipliers. A targeted training that...

Incorporating data drift to perform survival analysis on credit risk

Survival analysis has become a standard approach for modelling time to default by time-varying covariates in credit risk. Unlike most existing methods that implicitly assume a stationary data-generating process, in practise, mortgage portfolios are exposed to various forms of dat...

Longitudinal progression, metrics, age-dependence, and modifiers of ataxia severity in SCA27B: a multicentre study of 219 patients

Background Spinocerebellar Ataxia 27B (SCA27B) is a novel, frequent and likely treatable late-onset autosomal-dominant ataxia caused by GAA repeat-expansions in FGF14 . For understanding disease evolution and imminent trial planning, metrics of the most widely used clinical outco...

Environmental context effects on affective and cognitive empathy in virtual reality

Abstract Human interaction invariably occurs within a specific context. Although recent research highlights the role of context for emotion communication, the specific influence of the environmental ambience (the setting’s atmosphere) is less understood. This study investigated t...

Dioxygen Reduction at a Cu(I) Complex Supported by a Macrocyclic N 3 O Ligand System

ABSTRACT Cu I (14 TMCO) ( 1 ), involving a N 3 O‐macrocycle, reacts with O 2 at cryogenic temperatures to yield an end‐on peroxodicopper(II) species. The N 4 ‐analogue Cu I (14‐TMC) ( 2 ) remains unreactive under similar conditions. 2 contains an average short Cu─N bond length, r...

Parameter-light algorithms for improving hypermodularity-based community detection

Abstract Community detection is a central problem in network science, traditionally performed on graphs, often via modularity maximization. Yet, many real-world systems inherently involve higher-order interactions between more than two entities, naturally modeled as hypergraphs....

The parameter estimation tables (PEtab) format version 2

Abstract Parameter estimation is a central task in data-driven computational modeling, and a clear, unambiguous, and commonly understood specification of parameter estimation problems is essential for reproducibility and interoperability. PEtab provides a standardized framework f...

CMR-based aortic stiffness parameters in a symptomatic high risk obstructive sleep apnea cohort: results from the population-based Hamburg City Health Study

Abstract Background Aortic stiffness (AS) parameters as pulse wave velocity (PWV), aortic distensibility of the ascending and descending aorta (AD AoAsc, AD AoDesc) and pulse pressure (PP) are marker for vascular ageing, whereas data concerning obstructive sleep apnea (OSA) in po...

Variation in glabrous skin physiology across anatomical locations on the human hand

Abstract Skin physiology varies greatly between anatomical locations, with impact on tactile sensitivity. Research on the variations in morphology and physiology between different anatomical locations of glabrous skin is limited so far. This study investigates the morphology and...

Algorithmic disciplinarization: how AI reconfigures the governance of (in)dividuals by online platforms

Abstract Purpose This paper examines how artificial intelligence (AI) reconfigures platforms’ governance of individuals’ conduct and communication through a repurposing of the Foucauldian notion of disciplinary power. It offers a conceptualization of how AI-driven content moderat...

Cardiac Opioid System and Its Role in Heart Failure and Ischemia–Reperfusion Injury

Opioid receptors and peptides act as modulators of cardiac and vascular function. These effects are mediated not only by central mechanisms but also via a local cardiac opioid system, which has gained increasing attention for its potential role in cardiovascular disease and perio...

Investigating a Devonian vertebrate assemblage with synchrotron microtomography of coprolites

Abstract Fossilised faeces (coprolites) are a unique source of information as they record palaeontological evidence of animal behaviour (autecology) as well as interactions between extinct organisms and their environment (synecology). Four samples bearing coprolites found in a ne...

Tirzepatide Use Is Associated with Reduced Risk of Carpal Tunnel Syndrome in Overweight and Obese Adults

This study aimed to evaluate the association between tirzepatide use and the risk of carpal tunnel syndrome (CTS) and CTS surgery compared with both glucagon-like peptide-1 receptor agonists (GLP-1RAs) and other anti-obesity medications in individuals who are overweight or obese....