Huazhong University of Science and Technology

Design, Synthesis, and Biological Evaluation of Novel, Fluorinated Camptothecin Derivatives as Potential Topoisomerase I Inhibitors

Abstract Camptothecin (CPT), a classical topoisomerase I (TOP I) inhibitor, shows potent antitumor activity but is limited by toxicity and lactone instability. Herein, structural optimization of the CPT scaffold was conducted via A-ring fluorination and C-7 and C-17 modifications...

Intrapartum ultrasound in the second-stage labor: a meta-analysis and evidence appraisal of clinical outcomes and safety

Abstract Background Accurate assessment of fetal head position and descent during the second stage of labor is essential for safe decision-making, but digital examination is subjective and operator-dependent. Intrapartum ultrasound has been proposed as an objective adjunct, yet i...

Competitive Anion Coordination Modulates Anode Interfacial Chemistry for Wide‐Temperature Sodium Batteries

ABSTRACT Sodium‐ion batteries (SIBs) offer a promising, cost‐effective alternative for large‐scale energy storage due to the abundance of sodium. However, their practical deployment is challenged by sluggish interfacial kinetics and unstable interphase formation, which severely l...

Localized and delayed response of mold temperature to cooling channel activation in low-pressure die casting of aluminum alloy wheels

Low-pressure die-casting is the main forming method for aluminum alloy wheels, and the response characteristics of permanent mold temperature to the activation and deactivation of cooling channels are an important basis for the design and control of the cooling system in the low-...

Clinical study of neuromuscular electrical stimulator for prevention of intraoperative lower extremity deep vein thrombosis in patients undergoing lithotomy position surgery

Objectives: To investigate the efficacy and safety of neuromuscular electrical stimulation (NMES) for preventing lower-extremity deep venous thrombosis (DVT) during lithotomy position surgery. Methods: Seventy-six patients receiving lithotomy position surgery were randomized equa...

Combined Bioinformatic Analysis and RNA Sequencing Uncover Key Tinnitus-Related Molecules in the Cingulate Gyrus

Tinnitus arises from maladaptive plasticity and abnormal synaptic function, not only in auditory pathways but also in limbic regions. Among these, the cingulate gyrus plays a pivotal part in shaping the emotional burden and sensory filtering disturbances often seen in tinnitus pa...

Revisiting the effect of the (in)congruence between foreign language classroom anxiety and enjoyment on self-perceived proficiency: A conceptual replication and extension of Botes et al. ()

Abstract Using polynomial regression with response surface analysis (PRRSA) with an international sample, Botes et al. (2022a) found that self-perceived proficiency (SPP) varied in complex ways when foreign language classroom anxiety (FLCA) and foreign language enjoyment (FLE) we...

Boosting Burst I/O Performance under Heterogeneous Hybrid Storage Workloads via DUal I/O IssuE Thresholds

I/O schedulers are the key component to maintain high quality of services under homogeneous hybrid storage workloads, e.g., multiple concurrently running sustained workloads. However, the long hardware queue for I/O requests under I/O schedulers, which is utilized to exploit the...

From single-sequence structure prediction to protein fitness landscape through a composable, epistasis-aware mutation atlas

Mapping the multi-mutant fitness landscape is vital to protein engineering, but is challenging due to the vast combinatorial sequence space awaiting exploration. A central difficulty lies in the accurate and efficient modeling of non-additive epistatic effects among individual mu...

IFNγ-dependent tumor-cell MHC-II is restrained by MAPK signaling and associated with immunotherapy responsiveness in pancreatic ductal adenocarcinoma

Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by an immunosuppressive tumor microenvironment (TME) and poor prognosis. Although major histocompatibility complex class II (MHC-II) is typically expressed by professional antigen-presenting cells, its regulation a...

Defective PDZK1 palmitoylation impairs epididymosome-mediated cholesterol transport and contributes to asthenozoospermia

Asthenozoospermia, a leading cause of male infertility characterized by impaired sperm motility, involves dysregulated cholesterol efflux during epididymal maturation, yet the underlying mechanisms remain elusive. Here, we demonstrate that PDZK1 protein level and its palmitoylati...

Tissue-adjusted transcriptomic pathway differences between class IV and class V lupus nephritis

Introduction: Lupus nephritis (LN) is molecularly heterogeneous, and transcriptomic comparisons of histological classes can be confounded by renal tissue compartment and repeated sampling of the same patient. Materials and methods: We reanalyzed GSE127797 to compare class IV with...

Governance mechanisms for Low-value recyclable waste recycling under dual information asymmetry and residents’ perceived value

The recycling of Low-value recyclable waste (LVRW) suffers from low economic value, high collection costs, and weak resident participation, resulting in sustained reliance on government subsidies. However, asymmetric information on recyclers’ ability and effort leads to subsidy m...

Neural processing of speech envelopes from different languages and post-stimulation functional connectivity in newborns: an fNIRS study

Speech envelopes convey low-frequency temporal structure, including speech rhythm and prosody, and provide important cues for early speech processing in newborns. However, how the newborn brain processes speech envelopes and how brief exposure to them affects post-stimulation neu...

Dynamic study on improving the load ramp rate of a 630 MW subcritical coal-fired boiler by introducing a small pulverized coal silo

To accommodate large-scale renewable energy integration, enhancing the flexible load ramp capability of Coal-Fired Power Plants (CFPPs) is crucial. However, the inherent physical delay of traditional direct-fired pulverizing systems severely restricts further improvements in the...

Gut microbiome mediates the protective effects of empagliflozin on experimental abdominal aortic aneurysm formation and progression

Abdominal aortic aneurysm is a life-threatening vascular disease lacking effective pharmacotherapies. This study aimed to investigate the protective effect of empagliflozin, a sodium-glucose cotransporter 2 (SGLT-2) inhibitor, against angiotensin II (AngII)-induced AAA in ApoE −/...

LAMP: Large-Area Molecular Mapping Platform

Abstract By providing unique chemical specificity and quantitative metabolic imaging, label-free stimulated Raman scattering (SRS) and coherent anti-Stokes Raman scattering (CARS) microscopy is now emerging as the next-generation clinical decision maker by providing molecular con...

Conformal slit mapping based spiral tool trajectory planning for ball-end milling on complex freeform surfaces

We propose a spiral-based complete coverage strategy for ball-end milling on perforated freeform surfaces, using conformal slit mapping to produce compact, smooth, and evenly spaced toolpaths. Extending prior methods, our algorithm embeds continuous spiral trajectories directly i...

Nonlocal dielectric response and screening in ionic liquids

The dielectric response of room-temperature ionic liquids (RTILs) plays a central role in charge screening within these strongly correlated ionic fluids and thereby governs ion transport, electrochemical kinetics, solubility, and related electrochemical phenomena. Here, we presen...

Association of C-reactive protein-triglycerides-glucose index-waist-to-height ratio with mortality in metabolic dysfunction-associated steatotic liver disease (MASLD): evidence from two cohort studies

Abstract Background MASLD significantly increases the risk of cardiovascular events and all-cause mortality (ACM). The impact of the C-reactive protein-triglyceride-glucose index (CTI) and its derivatives on mortality in the MASLD population remains unclear. This study aimed to i...