Huazhong University of Science and Technology

Multi-omics convergence screening reveals dual-cargo antitumor mechanisms of orally administered Houttuynia cordata-derived exosome-like nanoparticles

Plant-derived exosome-like nanoparticles (PELNs) transport multi-component molecular cargos with cross-kingdom regulatory potential and have emerged as a promising class of cancer nanomedicines. A persistent bottleneck, however, is causally linking individual cargo species to in...

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

ABSTRACT The sterility and controllable biological functionalities of implantable medical devices determine their lifespan, safety, and therapeutic efficacy. Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, we have developed a...

Perception and coping with aging among middle-aged women: a qualitative study

Middle-aged women face distinct physiological, psychological, and social challenges during the transition from adulthood to later life. However, their perceptions of aging and the strategies they employ to cope with this process remain insufficiently understood. This qualitative...

The Safety and Feasibility of Laryngeal Mask Airway Management in Nonintubated Subxiphoid–Subcostal Thoracoscopic Thymectomy: Preliminary Results

Introduction While intubated general anesthesia with single-lung ventilation is regarded as mandatory for conventional thoracoscopic surgery, and various minimally invasive approaches to thymectomy have been described, nonintubated thoracoscopic thymectomy remains technically cha...

A comparative study on the names of higher education institutions in China and the United States: quantitative linguistic approaches

This study adopts quantitative methods to analyze the linguistic features of the names of higher education institutions in China and the United States (US). The findings reveal both similarities and differences in the university names of the two countries. Firstly, the Zipf-Mande...

GRB 260310A / SN 2026fgk: A Multi-Wavelength Study of a Nearby Underluminous Long GRB and SN with a Complex Afterglow

Abstract We present a comprehensive multi-wavelength study of GRB 260310A / SN 2026fgk, a nearby (z = 0.153), long-duration gamma-ray burst (GRB) with an exceptionally underluminous prompt γ-ray emission and a Comptonized spectrum. The burst occurred at the edge of a blue host ga...

Aggregation-Induced Emission: Illuminating the Path from Photothermal Ablation to Systemic Immunity

Abstract Cancer photothermal immunotherapy has attracted great attention in cancer treatment for its ability to trigger systemic antitumor immune responses and reverse tumor immune tolerance, offering prospects for clinical application. However, conventional photothermal agents s...

Single-Cell RNA Sequencing Reveals T-Cell Metabolic Activation and SGPL1 as a Candidate Predictor of PD-1 Resistance in Urothelial Carcinoma

Background/Objectives: Immune checkpoint blockade targeting the PD-1/PD-L1 axis is a standard treatment for urothelial carcinoma (UC), but 20–30% of patients develop resistance. The underlying mechanisms, particularly regarding tumor microenvironment metabolic reprogramming, rema...

Integrative multi-omics analysis identifies SMIM24 as a favorable prognostic biomarker in clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) exhibits substantial molecular and clinical heterogeneity, contributing to variable disease progression and therapeutic outcomes. We previously identified a de-clear cell differentiation (DCCD) tumor state characterized by loss of canonical...

Nuciferine-Loaded Lipid Nanoparticle Microneedles Alleviate Intervertebral Disc Degeneration by Restoring Nucleus Pulposus Cell Homeostasis

Background/Objectives: Intervertebral disc degeneration (IDD) is a major cause of chronic low back pain and disability. Nuciferine, a natural alkaloid with mitochondrial protective activity, shows therapeutic potential for IDD. However, the avascular nature of intervertebral disc...

Impact of smoke-free legislation on cigarette price and affordability in Wuhan, China: a repeated cross-sectional study

The smoke-free legislation (SFL) in Wuhan, China was adopted in January 2020. While its health benefits are documented, the impact on cigarette prices and affordability among smokers remains unclear. This study assessed the impact of Wuhan’s SFL on cigarette prices and affordabil...

Extinction-restraint intervention eradicates fear memory encoded in BLA engram cells via D2 receptor-mediated dopaminergic modulation from locus coeruleus

Abstract Despite undergoing exposure therapy, individuals with post-traumatic stress disorder (PTSD) frequently experience relapses when confronted with trauma reminders. This study examined the impact of extinction-restraint intervention (Ext-Res) in a PTSD-related fear relapse...

A Multi-View Attention–Similarity Decision-Support Framework for Core Feature Recognition in Design Patent Infringement Assessment

Identifying core features is a crucial step in design patent infringement assessments (DPIAs), as the identification results serve as a vital basis for subsequent qualitative and quantitative assessments. Traditional DPIAs typically rely on the experience and knowledge of experts...

Room-temperature multiferroicity in all–van der Waals heterostructures

Multiferroics host simultaneous and coupled ferroic orders, allowing disparate external stimuli to induce abrupt transformations in their structures and properties. Creating multiferroicity in two-dimensional (2D) van der Waals (vdW) platforms would add the elements of strong qua...

Neutrophil heterogeneity and crosstalk with cerebral-resident cells: therapeutic targets for ischemic stroke

Acute ischemic stroke elicits a robust inflammatory response within the brain. As one of the first peripheral immune cells to infiltrate the ischemic parenchyma, neutrophils show high heterogeneity and engage in complex crosstalk with resident brain cells. In this review, we firs...

A triboelectric nanogenerator sensor-based capture, positioning and release mechanism (CPRM) for test mass in TianQin Gravitational Wave detection Project

Space-based gravitational wave (GW) detection offers a powerful platform for observing millihertz GW signals and probing extreme astrophysical phenomena. As an important part for GW detection, monitoring key state during test-mass (TM) capture, positioning, and release is essenti...

Platformization Without High Commitment: The Institutional Resilience and Functional Limits of the Quad

ABSTRACT Since its revival in 2017, the U.S.–Japan–India–Australia Quadrilateral Security Dialogue (Quad) has continued to operate across multiple changes of government in its member states despite the absence of legally binding security commitments, and has extended its cooperat...

Hepatocyte OTUD1 promotes hepatic stellate cell activation and liver fibrosis by stabilizing HSP90β

Crosstalk between parenchymal and nonparenchymal cells of the liver mediates the activation of hepatic stellate cells (HSCs). Activated HSCs transform into myofibroblasts and produce the extracellular matrix (ECM), and massive ECM accumulation can affect liver function and eventu...

Effects of Hydrochars Derived from Woody Residues on Soil Enzyme Activities and Plant Response

The growing need for biomass waste recycling has led to increased interest in hydrothermal carbonization, which produces hydrochar as a by-product. This carbonaceous material can be applied in agriculture; however, its role in soil health is still not fully understood. Data on th...

The Role of Lachnospiraceae in Liver Diseases: Recent Advances and Clinical Application Prospects

Chronic liver diseases impose a considerable global public health burden, yet available treatment options remain largely inadequate. The gut microbiota exerts a key modulatory effect on liver disease pathogenesis via the gut-liver axis. Among them, Lachnospiraceae, a dominant bac...