Huazhong University of Science and Technology

Safflower yellow investigates AMPK/mTOR-mediated autophagy to mitigate sevoflurane-induced neuroinflammation and cognitive dysfunction

Background Perioperative neurocognitive disorders, including postoperative cognitive dysfunction (POCD), remain clinically important after surgery and anesthesia. This study evaluated the prophylactic neuroprotective effects of safflower yellow (SY) in a rat model of sevoflurane-...

PET imaging enables direct evaluation of ferroptosis in HCC synergistically induced by anti-PD-L1 and Olaparib

Abstract The efficacy of PET image-guided immune checkpoint inhibitor-based therapy in hepatocellular carcinoma (HCC) management is limited by the lack of direct monitoring of therapeutic response. A key challenge is the mismatch between the therapeutic pathway and the imaging ta...

Regeneration-aware online SOH estimation framework for liquid metal batteries based on fragmented data

Liquid metal batteries (LMBs) are regarded as a promising candidate for grid energy storage, owing to their long lifespan and high safety. However, their accurate state of health (SOH) estimation is significantly hindered by the prevalence of fragmented data and the pronounced ca...

HIF1α-dependent GGT5 expression promotes gastric cancer progression under hypoxia

The hypoxic tumor microenvironment fosters rapid growth and metastasis of carcinomas. Glutathione (GSH) plays a pivotal role in tumor metabolism. Understanding the mechanisms underlying GSH metabolism, including the role of hypoxia-inducible factor 1-alpha (HIF1α) in gastric canc...

Tailoring Piezoelectric Materials for High Energy Density Batteries: Fundamentals, Advances, and Perspectives

ABSTRACT High‐energy‐density rechargeable batteries are plagued by electrode polarization, unstable interfaces, and parasitic side reactions, which severely restrict their electrochemical performance across diverse battery chemistries. Piezoelectric materials can construct dynami...

Synthesis and Dynamic Control of Acousto‐Optic Multifocal Extended‐Depth‐of‐Focus Beams Based on the Superposition of Multi‐Chirp Signals

ABSTRACT Long depth‐of‐focus (DOF) beams maintain stable focusing over an extended axial range and are important for advanced microscopy, volumetric imaging, optical manipulation, and laser processing, particularly high‐aspect‐ratio glass micro‐hole drilling. Conventional methods...

Analysis of care needs for primary caregivers of premature infants at home based on the Kano model: A cross-sectional study

Objective This study applied the Kano model to analyze the attributes of care needs among primary caregivers of discharged premature infants(up to 6 months post discharge), identify priority needs, and provide a foundation for developing targeted nursing service plans. Methods Be...

Associations of Triglyceride Glucose Index-related Obesity Indices, Genetic Susceptibility, and the Risk of Venous Thromboembolism: Insights from a Prospective Cohort Study

Abstract The triglyceride glucose (TyG) index and related obesity metrics are commonly recognized as important indicators of insulin resistance. However, the associations of several novel TyG-related obesity indices developed with venous thromboembolism (VTE) risk and their inter...

Respiratory Pathogen Spectrum Among 12,220 Testing Episodes for Clinically Suspected Acute Respiratory Infection in Predominantly Hospitalized Patients at a Tertiary Hospital in Wuhan, China, 2025: A Retrospective Cross-Sectional Study

Acute respiratory infections (ARI) impose a substantial global disease burden, yet the post-pandemic pathogen spectrum in central China remains incompletely characterized. This single-center retrospective cross-sectional study analyzed 12,220 consecutive testing episodes in which...

Two Faces of the Same Oxide: How Crystal Phase Defines the Nature of Proton Storage in MoO3

Abstract Proton storage in transition-metal oxides is often linked to fast proton transport, but how crystal phase governs structural evolution, electronic response, and kinetics remains insufficiently understood. Here, α-MoO3 and h-MoO3 are compared as model polymorphs to reveal...

Circadian photoreceptor CRYPTOCHROME promotes wakefulness under short winter-like days via a GABAergic circuitry

A cardinal symptom of seasonal affective disorder (SAD, also known as winter depression) is hypersomnolence, while the cause of this ‘winter sleepiness’ is not known. Here, we found that lack of the circadian photoreceptor cryptochrome ( cry ) leads to increased sleep under short...

Magnetization Dynamics-Modulated Near-Infrared Mie Scattering Enables Homogeneous Femtomolar Immunosensing for Whole Blood

Abstract Low-abundance biomarkers in whole blood hold immense clinical value for disease diagnosis. However, their detection remains constrained by the difficulty of conventional assays in simultaneously achieving high sensitivity, rapid turnaround, and operational simplicity. He...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Indispensable Interphase Passivation in Solvation‐Regulated Propylene Carbonate Electrolytes for Ah‐Level Lithium‐Ion Batteries at −50–120°C

ABSTRACT Propylene carbonate (PC) is a high‐permittivity, wide‐temperature solvent, but the Li + ‐PC co‐intercalation issue in graphite (Gr) anode curtailed its application in lithium‐ion batteries. Although solvation engineering suppresses co‐intercalation, long‐term cycling is...

Interfacial ferroelectricity at naturally-formed van der Waals interfaces

Sliding ferroelectrics emerge as compelling candidates for next-generation wafer-level non-volatile storage applications with low power consumption and high packing density. However, artificially stacked sliding ferroelectrics with homogeneous/heterogeneous interfaces rely on hig...

Defect-engineered lithium-coated BaTiO3 to enable high oxide-ion conduction in LT-SOFC

Solid oxide fuel cells (SOFCs) are emerging as transformative electrochemical energy conversion technologies owing to their superior efficiency, fuel versatility, and minimal environmental impact. Enhancing SOFCs for efficient performance at low temperatures (LT, 420–520 °C) requ...

The Shared Pathological Niche in Pulmonary Fibrosis: From Aberrant Epithelial Repair to ECM Remodeling

Pulmonary fibrosis is a frequent complication of abnormal tissue repair following lung injury by many causes. It can be found in various diseases and clinical conditions, such as idiopathic pulmonary fibrosis, cancer-treatment-induced lung injury, and other occupational, environm...

AI-assisted discovery of an ABCA1/ABCG1 activator for restoring mitophagy and mitigating Alzheimer’s pathology

Abstract Defective mitophagy is a key pathological risk of Alzheimer’s disease (AD), yet available pharmacological agents capable of restoring mitophagy remain clinically limited, largely due to the lack of tools for drug screening and target identification. To address this, we i...

Crisis communication strategies, government reputation signals, and health compliance willingness during COVID-19: a randomized experiment in the context of China’s zero-COVID policy

Although government reputation is widely recognized as a resource for securing public compliance during health crises, little is known about which specific reputational attributes members of the public rely on when forming trust and deciding whether to comply with costly protecti...

GPU-accelerated parallel strategies for multiscale isogeometric topology optimization

In multiscale isogeometric topology optimization (ITO), the highly coupled cross-scale sensitivity analysis and the wide support of NURBS basis functions constitute the dominant computational bottleneck. To address these computational bottlenecks, this paper proposes a Decoupled...