Huazhong University of Science and Technology

RITRA: A Rolling Bayesian Information-Theoretic Framework for Multi-UAV Task Allocation Under False Alarm Uncertainty

In complex operational environments, signal ambiguity and false alarms make task allocation for multiple unmanned aerial vehicles (UAVs) challenging. To address this problem, we propose the Bayesian Rolling Information-Theoretic Reconnaissance Action Assignment (RITRA) framework....

Cancer drug response and resistance: molecular mechanisms and combating strategies

Despite remarkable advances in cancer drug treatment, including chemotherapy, targeted therapy, and immunotherapy, therapeutic resistance remains a formidable clinical barrier, limiting durable responses and long-term survival. Drug resistance can be broadly categorized as intrin...

Calibration method of driving energy for vaporizing foil actuator welding and its application

In this study, a driving energy calibration method applicable to the vaporizing foil actuator (VFA) was proposed and applied to the process of vaporizing foil actuator welding (VFAW). This method is based on a technical approach combining high-speed photography with finite elemen...

Physics‐Informed Neural Networks for Flexoelectric Boundary Value Problems: A Reformulated Architecture for High‐ and Mixed‐Order Electromechanically Coupled Systems

ABSTRACT Flexoelectricity denotes a universal electromechanical coupling in dielectric materials, whereby strain gradients break local inversion symmetry and induce electric polarization. The resulting boundary value problem (BVP) is governed by a coupled multi‐physics system of...

Smart Rubber Composites for Building Structure Monitoring: Laboratory Experiments and Molecular Simulations

Abstract Intelligent sensing technology offers great promise for structural health monitoring (SHM) of building structures. Nevertheless, conventional strain sensors suffer from fragility, low sensitivity, and limitations in real-time monitoring, which have hindered their widespr...

Nasolacrimal duct obstruction following allo-HSCT: an overlooked manifestation of ocular graft-versus-host disease

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for a broad spectrum of benign and malignant haematological disorders [ 1 ]. However, graft-versus-host disease (GVHD) remains a major long-term complication, with ocular involvement occurring...

Longitudinal dynamics of the maternal gut virome associate with metabolic features of preterm birth

Preterm birth (PTB) remains a major pregnancy complication, yet the role of the maternal gut virome in its etiology is largely unknown. Here we show that the maternal gut virome undergoes ecological destabilization prior to PTB, coupled with distinct host metabolic remodeling. Ne...

Spatially defined IGF1R-STMN1 axis delineates a metastatic cell state in osteosarcoma

Abstract Metastatic osteosarcoma (OS) remains the leading cause of disease-related mortality, yet effective therapies are still lacking. Here, we integrated single-cell RNA sequencing, spatial transcriptomics, and functional assays to investigate signaling dependencies in OS meta...

Signal Detection and Temporal Analysis of Aromatase Inhibitor‐Associated Hepatotoxicity: A Pharmacovigilance Study Integrating Bayesian Belief‐Propagation Network and Frequentist Metrics

ABSTRACT Background This study assessed the real‐world hepatotoxicity of third‐generation aromatase inhibitors (AIs) for breast cancer using pharmacovigilance approaches. Methods FAERS data (Q1 2004–Q1 2025) were analysed using a data‐driven disproportionality analysis framework...

Deciphering the mechanistic landscape of notch signaling in autoimmune pathogenesis

Autoimmune diseases are a group of disorders with multiple etiologies that disrupt normal immunological function, leading to the immune system mistakenly attacking the body’s own tissues. The Notch signaling pathway is a conserved pathway that is in part responsible for multiple...