Huazhong University of Science and Technology

Finite-Resource Estimates of Riemann Zeros: Laboratory Diagnostics and a Conditional Cosmic-Time Hypothesis

Physical systems can encode functions whose zeros correspond to Riemann-zero ordinates, but estimation precision depends on encoding, calibration, noise and resources. We reassess whether experiments support a universal observable-height ceiling or its increase with cosmic age. R...

An Inverse-Squared-Logarithm Hubble Normalization: Conditional Distance Fits and Scalar-Field Reconstructions

Motivated by our numerical study of a non-autonomous spectral construction, we test inverse-squared-logarithm time dependence of an effective Hubble normalization, with exponential and power-law forms as comparisons. The extension from an iteration-dependent parameter to cosmic t...

An Inverse-Squared-Logarithm Fine-Structure History: Conditional Tests with Atomic Clocks and Quasar Spectra

Motivated by our numerical investigation of a non-autonomous spectral construction, we test a fine-structure history $\Delta\alpha/\alpha_0=\Gamma\{\ln^{-2}(t/t_*)-\ln^{-2}(t_0/t_*)\}$. Identifying an iteration index with cosmic time and coupling the structural parameter to elect...

Association of multisite pain with incident ADL limitation and depressive symptoms in older Chinese adults: a two-year longitudinal cohort study

Abstract Background Multisite pain is common among older adults and may reflect broader health vulnerability beyond pain at a single anatomical site. However, longitudinal evidence on the associations of pain-site distribution with subsequent functional and psychological outcomes...

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI), but therapeutics that modulate key inflammatory amplifiers remain limited. Here, we identify infiltrating macrophages as the predominant TREM1‐expressing population in TBI human and...

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

ABSTRACT Coronaviruses have persistently triggered global pandemics in the 21 st century, featuring either high transmissibility or high pathogenicity. A hallmark of these infections is the delayed activation of innate immune responses, resulting in dysregulated antiviral signali...

Over 20% Efficiency in As–Cast Organic Solar Cells Enabled by Flory–Huggins Parameter Engineering

ABSTRACT The realization of high–efficiency as–cast organic solar cells (OSCs) represents a key step toward simplified processing and scalable fabrication for commercialization. However, achieving high–performance as–cast devices remains challenging because it demands delicate ba...

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

ABSTRACT Acquired resistance to temozolomide (TMZ) remains a major therapeutic challenge in glioblastoma (GBM), with metabolic reprogramming emerging as a critical driver of treatment failure. Procollagen lysyl hydroxylase 1 (PLOD1) is identified as a key regulator of adaptive me...

Transformer‐Based Multitask Framework Integrating Habitat and Deep Learning for Predicting Early Disease Control and Survival in Immunotherapy‐Treated Hepatocellular Carcinoma

ABSTRACT Hepatocellular carcinoma (HCC) patients show heterogeneous responses to immune checkpoint inhibitors (ICIs). This study developed ECOS‐Net, a transformer‐based multitask network integrating CT‐derived habitat and 2.5‐dimensional (2.5D) deep learning features for simultan...

Bare‐Die Antiferromagnetic Computing

Semiconductor electronic devices are increasingly constrained by fundamental quantum tunneling effects and charge-based mechanisms, which severely limit further miniaturization, write-speed scaling, and environmental robustness of silicon-based technologies. These limitations are...

Percolation‐Driven β ‐Relaxation Enables Resonant Acceleration of Crystallization in Amorphous Phase‐Change Materials

ABSTRACT Amorphous phase‐change materials enable fast and reversible switching in optical and electronic devices, yet crystallization kinetics are still controlled primarily through empirical thermal protocols. Here we identify a microscopic picture governing crystallization in t...

La-induced stabilization of Fe-Ni active phases in NiFe2O4 via in situ LaFeO3 formation for efficient CO2 hydrogenation to CO

Catalytic hydrogenation of CO 2 to CO via the reverse water-gas shift (RWGS) reaction provides an attractive route for renewable hydrogen utilization and carbon recycling. NiFe 2 O 4 spinels are promising RWGS catalysts owing to abundant oxygen vacancies and excellent CO 2 activa...

Payment reform, remuneration incentives, and changes in service utilization and institutional revenue composition: an interrupted time-series analysis from Sanming, China

Hospital-centred service delivery and underused primary care can reduce health-system efficiency. We examined changes in service utilization, provider distribution, and institutional revenue composition during Sanming’s health reform. We analysed 144 monthly observations from Jan...

Responsibility vs. sensationalism: A cross-cultural review of media coverage of sexual violence

In this study, the media coverage of various incidents of sexual violence across the various countries of the world has been analyzed, and to surface that whether the media is responsible, sensational or neutral in coverage of such events. Media Coverage of sexual violence is exa...

Regulatory T cells in liver diseases: roles and therapeutic targeting

The liver is an immune-tolerogenic organ in which coordinated interactions between resident and infiltrating immune cells maintain hepatic and systemic homeostasis. Disruption of this balance can lead to chronic inflammation, fibrogenesis, infection, and malignant transformation,...

Competitive Anion Coordination Modulates Anode Interfacial Chemistry for Wide‐Temperature Sodium Batteries

ABSTRACT Sodium‐ion batteries (SIBs) offer a promising, cost‐effective alternative for large‐scale energy storage due to the abundance of sodium. However, their practical deployment is challenged by sluggish interfacial kinetics and unstable interphase formation, which severely l...

Design, Synthesis, and Biological Evaluation of Novel, Fluorinated Camptothecin Derivatives as Potential Topoisomerase I Inhibitors

Abstract Camptothecin (CPT), a classical topoisomerase I (TOP I) inhibitor, shows potent antitumor activity but is limited by toxicity and lactone instability. Herein, structural optimization of the CPT scaffold was conducted via A-ring fluorination and C-7 and C-17 modifications...

Ultrasound-activatable bacteria for biomedical applications

Bacteria have emerged as powerful therapeutic vectors owing to their intrinsic tumour tropism, genetic programmability, and living therapeutic functions. However, the trade-off between their autonomous proliferation and potential immunotoxicity restricts their clinical translatio...

Intratumoral and peritumoral delta radiomics of MRI predicts overall survival to targeted therapy in colorectal cancer with liver metastases

To develop and validate a hybrid prognostic model integrating clinical, MRI, and radiomics features for predicting overall survival (OS) in patients with colorectal cancer liver metastases (CRCLM) undergoing targeted therapy. This retrospective, multicenter study included 118 CRC...

Efficient Acidic H2O2 Electrosynthesis over Co Atoms Anchored on Nitrogen-Doped Hierarchical Porous Carbon

The two-electron oxygen reduction reaction (2e− ORR) presents a promising route for the on-site production of hydrogen peroxide (H2O2), offering a green alternative to energy-consuming anthraquinone process. However, the high selectivity toward the competing 4e− ORR over the desi...