Huazhong University of Science and Technology

Enzyme Engineering:From Classical Strategies to AI-DrivenBiocatalyst Design

Abstract Nowadays, enzyme engineering has moved from traditional structure-based mutagenesis and directed evolution to data-intensive, AI-assisted design paradigms that involve the rapid discovery and optimization of biocatalysts. Whereas classical approaches relied on rational d...

Stage-dependent performance and molecular subtype-specific relapse patterns on same-session [18F]FDG PET/contrast-enhanced CT in breast cancer

PURPOSE: To evaluate stage-dependent performance of same-session [18F]FDG PET/contrast-enhanced CT (PET/ceCT) for initial breast cancer staging and PET/ceCT-detected relapse patterns during follow-up. METHODS: This retrospective single-centre study included a primary staging coho...

Fully tunable on-chip meta-generator for multidimensional Poincaré sphere mapping

Abstract The angular momentum of light can be elegantly mapped onto high-order Poincaré spheres, providing a powerful framework for describing structured light beams. Such beams have shown extraordinary potential across diverse applications, including high-capacity optical commun...

A Certificateless Encryption-Based Authentication Protocol for Low Earth Orbit Satellite Network

In this letter, a novel access and handover authentication scheme is proposed for Low Earth Orbit (LEO) satellite networks, aiming to achieve lightweight computation, privacy preservation, and seamless secure handover for massive sensor users. Different from traditional certifica...

Dual-tracer 18 F-FDG and 68 Ga-DPI-4452 PET revealed distinct features of synchronous multiple renal cell carcinomas

A 66-year-old male presented with gross hematuria and a left renal mass. 18 F-FDG PET/CT revealed an FDG-avid mass in the mid-pole of the left kidney with renal vein tumor thrombus. The patient was subsequently enrolled in a clinical trial evaluating the carbonic anhydrase IX (CA...

Electronic‐Geometric Pre‐Compensation Enables Intermetallic RhSb Bimetallenes for Efficient Nitrite Electroreduction

ABSTRACT Sustainable electrochemical synthesis aims to produce high‐value chemicals under mild conditions, but its advancement is hindered by electrocatalyst deactivation caused by the strong adsorption of poisoning intermediates. Strategies that mitigate deactivation by weakenin...

Checkpoint-insulated triple-signal artificial antigen-presenting cells drive antigen relay and systemic antitumor immunity

Dendritic cell (DC) vaccines offer professional antigen presentation but are often limited by suboptimal trafficking to lymphoid tissues, whereas whole tumor cell vaccines preserve antigenic diversity yet frequently lack coordinated activation cues for efficient T cell priming. H...

Network‐Structured All Organic Composite for High‐Temperature Capacitive Energy Storage

ABSTRACT High‐temperature dielectric polymers are promising for advanced power electronics and electrical systems but often suffer from thermally activated charge transport and breakdown under harsh operating conditions. Here, we demonstrate that high‐loading low‐molecular‐weight...

The COACH theory formalizes clinical reasoning in the development and validation of medical artificial intelligence systems

The development and deployment of medical artificial intelligence (AI) systems are limited by two persistent gaps: clinician knowledge is often introduced late in development as labels or annotations, and deployed systems often provide outputs that are difficult to reconcile with...

A non-invasive simplified scoring system to predict airway mucus plugs in asthma

Abstract Background Airway mucus plugs are a core pathological feature of severe asthma and are closely associated with airflow limitation and poor prognosis. However, rapid and efficient clinical screening tools for identifying airway mucus plugs in asthma are currently lacking....

The Unsaturated/Saturated Fatty Acid Ratio: A Metabolic Hub and Therapeutic Vulnerability in Glioblastoma

Glioblastoma (GBM) exhibits profound metabolic reprogramming, among which the balance between unsaturated and saturated fatty acids (UFA/SFA) emerges as a critical determinant of tumor behavior and treatment response. Recent studies have shown that fatty acid metabolic reprogramm...

Attitudes to sex education among undergraduates without medical background in China

This study, guided by the Knowledge-Attitude-Practice (KAP) theory, aimed to investigate the knowledge, attitudes, and needs regarding sex education among undergraduates without medical background at Huazhong University of Science and Technology in Wuhan, China. This cross-sectio...

Hybrid Ultrahigh-QualityEtchless Microcavity forApplications with Low-Dimensional Materials

Abstract Two-dimensional (2D) materials possess exceptional optical properties, holding great potential for the development of advanced linear and nonlinear optoelectronic devices. However, their efficient integration into photonic circuits remains challenging due to the trade-of...

How Do Households Respond to Expected Inflation? An Investigation of Transmission Mechanisms,

Abstract We investigate the channels through which inflation expectations affect household spending by conducting surveys featuring hypothetical scenarios involving an increase in inflation expectations. Most households did not adjust their current spending plans, often because t...

Neutrophil percentage-to-albumin ratio is associated with in-hospital mortality in patients with acute aortic dissection: a multicenter retrospective cohort study

Early risk stratification remains challenging in patients with acute aortic dissection (AAD). This study aims to evaluate the prognostic value of neutrophil percentage-to-albumin ratio (NPAR) for in-hospital mortality in patients with acute aortic dissection. We performed a multi...

A hierarchical whole-body control framework for humanoid robots in shelf-picking

Purpose This paper aims to present a hierarchical whole-body control (H-WBC) framework for humanoid shelf-picking in structured shelf environments. The objective is to improve motion coordination, posture regulation and safe task execution for humanoid manipulation in spatially c...

Polymer Substrates for Flexible Sensors: Advances and Contributions to Smart Agriculture

ABSTRACT The advancement of smart agriculture is becoming increasingly dependent on sensor technologies that enable the digitization and optimization of agricultural processes. Traditional sensors, however, are constrained by their inherent rigidity, poor conformability to irregu...

Palmitoylation of TK1 exacerbates osteoarthritis by promoting JNK-mediated metabolic reprogramming

Osteoarthritis (OA) lacks approved disease-modifying therapies. Here, by integrating quantitative proteomics with reanalysis of public single-cell RNA sequencing data from human articular cartilage, we identify thymidine kinase 1 (TK1) as a pathogenic regulator linking inflammato...

Fail-Slow Hardware Failure Bug Analysis and Detection for Cloud Systems

Fail-slow hardwares are still running and functional, but in a degraded mode, thus slower than their expected performance. Bugs triggered by fail-slow hardwares cause severe cloud system failures. Existing testing tools fail to efficiently detect these bugs due to overlooking the...

Understanding and Detecting Android R8 Compiler Bugs

Android apps currently dominate the smartphone app market, and their reliability will significantly affect user experience and even induce security risks. Since Android Gradle Plugin 3.4.0 (April 2019), the R8 compiler serves as the default infrastructure in the Android build pro...