Huazhong University of Science and Technology

Extended follow-up of in vivo BCMA CAR-T therapy in relapsed/refractory multiple myeloma

Data on long-term outcomes of in vivo chimeric antigen receptor T cell (CAR‑T) therapy remain scarce. We previously reported preliminary safety and efficacy data of in vivo B-cell maturation antigen (BCMA) CAR‑T (ESO-T01), in four patients with relapsed/refractory multiple myelom...

Mitochondria-Accumulating Nonplanar Perylene Diimides Suppress Mitochondrial DNA Transcription for Antitumor Therapy

Abstract Mitochondrial DNA (mtDNA) transcription is an emerging target in cancer therapy. While enzyme-targeted inhibitors like IMT1B block POLRMT, their organelle specificity remains unclear. Here, we report a distinct strategy using mitochondria-accumulating nonplanar perylene...

RAFA: RNA all-atom structure reconstruction from sparse anchor coordinates

SUMMARY: We present RAFA, a C ++ command-line tool for RNA all-atom structure reconstruction from sparse or partial coordinates. RAFA targets settings in which coarse-grained modelling, low-resolution fitting, or partial experimental interpretation provides RNA anchor atoms but n...

Associations between diabetic retinopathy and systemic complications in patients with type 2 diabetes mellitus: a retrospective cross-sectional analysis of the PHDA diabetes complications data set in China

To investigate the associations between diabetic retinopathy (DR) and selected systemic complications in patients with type 2 diabetes mellitus (T2DM). This retrospective cross-sectional study analyzed data from the National Population Health Science Data Center’s PHDA Diabetes C...

Experimental and numerical study on hysteretic performance of aluminum alloy weak-axis beam-to-column joint connected by ring-groove rivets

This study experimentally and numerically investigates the hysteretic behavior of aluminum alloy weak-axis joints connected by ring-groove rivets. Two full-scale cruciform joint specimens were tested, incorporating stainless steel side plate connections with different configurati...

Reframing decentralized diagnostics with a programmable multi-dimensional microfluidic system

Decentralized diagnostics are vital for infectious disease control, yet current point-of-care tools remain largely one-dimensional, failing to capture the multidimensional profiles required for precision management. Here, we show SID-WAVES (Smartphone-Integrated Diagnostics with...

Low-coercivity and high-resistivity medium-entropy alloy via binder jetting-enabled in-situ carbon doping

The advancement of power electronics demands soft magnetic materials combining magnetic properties with complex-shape manufacturability. Additive manufacturing (AM) offers a route for complex components but is limited by microstructural heterogeneity and residual stress, which de...

Single-nucleus transcriptomics uncovers region-specific molecular features underlying selective aging vulnerability of cholinergic neurons

Cholinergic neurons exhibit functional and molecular heterogeneity across the basal forebrain (BF), midbrain (MB), and brainstem (BS), while the aging-associated transcriptional features remain poorly characterized. Here, we performed single nucleus RNA sequencing (snRNA-seq) on...

Dynamic Sulfur Reservoir Programs Cation-Exchange Kinetics in PbS Quantum Dots for Short-Wave Infrared Imaging Chips

Abstract Cation-exchange synthesis produces monodisperse PbS quantum dots (QDs), yet its central limitation─precursor preparation and dropwise injection─is usually treated as a practical issue. Here, we recast it as sulfur chemical-potential programming; that is, ethyl ziram (EZ)...

Parametric finite element modeling and pose-dependent natural characteristics of a five-axis machine tool

Five-axis machine tools exhibit pose-dependent structural dynamics, but repeated full finite element reconstruction across the workspace is computationally inefficient. We developed a parametric finite element workflow in ANSYS APDL for a five-axis machine-tool analog specimen. T...

Degree Normalization Reshapes Collective Synchronization in Adaptive Kuramoto Networks

Collective dynamics in adaptive oscillator networks are shaped by both network structure and coupling-adaptation mechanisms, and separating the contributions of the two to synchronization is often difficult. We study a Kuramoto network with degree normalization and adaptive Hebbi...

Combined Effect of Courtyard Aspect Ratio and Wind Direction on Natural Ventilation in Educational Buildings Using a Porous-Media CFD Model

Natural ventilation is an important passive strategy for improving the indoor environmental quality of educational buildings. However, ventilation performance in courtyard buildings is strongly influenced by the interaction among building morphology, wind direction, and dense cla...

Integrated multi-omics analysis reveals the molecular landscape and therapeutic strategies in Chinese cervical cancer patients

Genomic or transcriptomic sequencing guides the precision of cervical cancer (CC) diagnosis; however, the molecular profile of Asian patients remains poorly understood. We established a comprehensive multi-omics cohort comprising 112 tumor-normal adjacent tissue pairs from Chines...

Wear and Corrosion Properties of Laser-Cladding Ti-Hf-Mo-Ta-Nb-B Coating on Ti60 Titanium Alloy

Ti60 is a type of high-temperature titanium alloy that not only withstands high temperatures during long-term service, but also has excellent wear resistance and corrosion resistance. To enhance the wear and corrosion resistance of a Ti60 substrate, a Ti-Hf-Mo-Ta-Nb-B coating was...

Arrayed Magnetic Accelerator Synergistically Enhances Orthodontic Tooth Movement via Microtubule Assembly‐Mediated Periodontal Remodeling

ABSTRACT Mechanical orthodontic treatment is regarded as a classical strategy for directional tooth movement in confront of malocclusion. However, prolonged remodeling period and adverse complication risks, which are mainly ascribed to inadequate sensation of bio‐mechanical cues,...

Economic feedback-guided forecasting and scheduling for microgrids using rolling model predictive control

Microgrid rolling energy management often follows a decoupled forecast-then-optimize workflow, where forecasts are trained separately from downstream rolling model predictive control (MPC) scheduling. However, lower statistical forecasting errors do not necessarily reduce operati...

Liquid biopsy, cfDNA, and machine learning: an integrative approach to cardiovascular diseases

Cardiovascular diseases (CVDs) and their complications remain the leading cause of mortality worldwide. However, obtaining diseased cardiovascular tissue is often invasive, costly, and clinically impractical, highlighting the need for noninvasive approaches that can capture dynam...

“Wait, My Tool Can’t Do That?” A Fine-Grained Capability Study of Modern Static Taint Analyzers

Static taint analyzers are widely used in software security, yet aggregate vulnerability-detection metrics provide limited insight into the specific language constructs and analysis capabilities that cause tools to succeed or fail. This paper presents xAST , a fine-grained benchm...

Upcoming novel treatments for hidradenitis suppurativa: An overview of the pipeline

Abstract Recent developments in hidradenitis suppurativa (HS) have focused on targeting key inflammatory pathways implicated in the pathogenesis of the disease, including interleukin (IL)‐17, IL‐1, tumour necrosis factor (TNF), Janus kinase (JAK) and tyrosine kinase 2 (TYK2) sign...

An efficient partitioning method for curved-surface laser texturing based on bipolar projection and multi-level pruning

Laser surface texturing (LST), as a highly promising technology, is applied to surface functional enhancement by forming special micron/nanometer-level texture structures. Curved-surface LST requires surface partitioning to satisfy laser process constraints. Dedicated partitionin...