Heinrich Heine University Düsseldorf

Real-world use of bempedoic acid for hypercholesterolaemia: a German multicentre, retrospective, cohort study

Abstract Background Dyslipidaemia remains a leading cause of death in Germany despite an improving therapeutic landscape, with many patients not achieving guideline-recommended low-density lipoprotein cholesterol (LDL-C) goals. Bempedoic acid, an adenosine triphosphate citrate ly...

Monitoring strategies in adults eligible for pharmacological lipid-lowering therapy

OBJECTIVES: This is a protocol for a Cochrane review (intervention). The objectives are as follows: To assess the effects of different laboratory monitoring strategies for treatment efficacy (lipid levels) and treatment safety (hepatic, muscular, and renal parameters) in adults e...

Service delivery interventions for lipid testing and lipid-lowering therapy for primary and secondary prevention of cardiovascular disease in adults

OBJECTIVES: This is a protocol for a Cochrane review (intervention). The objectives are as follows: To assess the effects of service-delivery interventions for lipid testing and lipid-lowering therapies, such as point-of-care testing and non-physician-led or collaborative care pr...

Do Androgens and Sex Hormone–Binding Globulin Mediate Sex Differences in the Risk of Stroke and Myocardial Infarction? The KORA Study

BACKGROUND: Sex differences in cardiovascular disease are well established, but the role of androgens and sex hormone-binding globulin (SHBG) remains unclear. We investigated whether these hormones and SHBG mediate sex differences in the risk of stroke and myocardial infarction (...

Adaptations to breath-hold diving: from traditional divers to elite athletes

Breath-hold diving exposes humans to repeated episodes of profound hypoxia and hypercapnia, eliciting physiological adaptations that enable prolonged underwater performance. This article summarises current knowledge on chronic adaptations in elite breath-hold athletes and traditi...

Maintained critical flicker fusion frequency after acute hyperbaric hyperoxia at 140 kPa

Introduction: In diving medicine, critical flicker fusion frequency (cFFF) has been employed to assess alertness under varying ambient pressures and gas compositions, yet the effects of elevated oxygen partial pressure on cFFF performance underwater remain inconsistently characte...

The continued influence effect and situation models: Evidence for the model-updating account

Abstract Information often continues to influence judgments even after retraction (Continued Influence Effect, CIE). According to the model-updating account, the CIE occurs because humans base their judgments on situation models that are not completely updated and, thus, continue...

Road transport of trapped antiprotons

Abstract Low-energy antiprotons confined in ultrahigh-vacuum Penning traps 1 enable precision investigations of charge, parity and time-reversal (CPT) invariance 2 to test the fundamental symmetry between matter and antimatter. These studies are driven by the search for physics b...

Efficacy, safety and circulating tumor cell dynamics in patients treated with Eribulin for HER2-negative advanced breast cancer – results from the phase II DETECT IVb trial

Abstract Background Eribulin is a non-taxane microtubule inhibitor that showed survival benefits for pretreated metastatic breast cancer (MBC) patients. Circulating tumor cells (CTCs) are a prognostic marker, but their role in predicting response to specific MBC treatments is les...

Pharmacological lipid-lowering therapies for primary and secondary prevention of cardiovascular disease in adults with dyslipidaemia: a systematic review and network meta-analysis

OBJECTIVES: This is a protocol for a Cochrane review (intervention). The objectives are as follows: Primary To compare the effects and safety of lipid-lowering therapies, including statin regimens (high intensity, moderate intensity, and low intensity), non-statin therapies, and...

Context-dependent siderophore exploitability shapes microbial community structure

Siderophores are classically viewed as shared iron-scavenging public goods, yet their ecological roles in multispecies communities remain incompletely understood. Here, we establish a synthetic microbial community to dissect how different siderophores, their uptake compatibility...

Exploring spatial heterogeneity of PD-L1 and c-MET expression in oral squamous cell carcinoma

Abstract Background PD-L1 expression is an established predictive biomarker for immune checkpoint inhibitor therapy in recurrent or metastatic head and neck squamous cell carcinoma (HNSCC), including oral squamous cell carcinoma (OSCC). However, the spatial heterogeneity of PD-L1...

Towards and beyond the ‘Fall’: rethinking Rome’s end

Knöpges, Ellen Muehlberger, and the three anonymous reviewers for their inspiration, helpful suggestions and critique.We particularly thank Neville

Parvovirus B19 infections in paediatric sickle cell disease patients: Genotype and hydroxyurea treatment influence disease severity

Summary In patients with sickle cell disease (SCD), parvovirus B19 infection (B19V) leads to acute anaemia (aplastic crisis), but may also be associated with other serious complications. We retrospectively analysed clinical data from paediatric SCD patients with B19V infections b...

Toll-like receptor 2 modulates age-associated insulitis and fibrotic remodeling of Langerhans islets

Abstract Background The steadily increasing aging population highlights the importance of maintaining health at an advanced age. Metabolic diseases are among the most prevalent age-related disorders, and the Langerhans islets, critical regulators of glucose homeostasis, are parti...

International consensus guidance for general population screening for islet autoantibodies to diagnose early-stage type 1 diabetes: a nominal group technique process

Type 1 diabetes is an autoimmune disease that targets and destroys insulin-producing beta cells in the pancreatic islets. The incidence of type 1 diabetes is rising globally. At the clinical diagnosis of type 1 diabetes, between 20% and 67% of children and adolescents present wit...

Dissection of superficial temporal artery for STA-M4 bypass, an integrated method. How I do it

BACKGROUND: Extracranial-intracranial (EC-IC) bypass is an effective revascularization technique for flow augmentation in conditions including Moyamoya disease and ischemic cerebrovascular disorders. Preparation of donor vessel is a key step for EC-IC Bypass surgery. This procedu...

Comparative Pharmacokinetics of Trientine Dihydrochloride Capsules: A Randomized, Open-Label, Reference-Controlled, Two-Period Crossover Study in Healthy Volunteers

Trientine dihydrochloride (TETA-2HCl) is an oral copper chelator used for Wilson disease. Because available formulations differ in marketed strength and may have formulation-specific pharmacokinetic properties, this study compared a 250 mg test capsule and a 300 mg reference caps...

Comparison of High‐Sensitivity Troponin T Versus N‐Terminal Pro‐B‐Type Natriuretic Peptide for Prediction of Major Adverse Cardiovascular Events After Noncardiac Surgery

Background Preoperative hs‐TnT (high‐sensitivity cardiac troponin T) and NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) are used for risk prediction in noncardiac surgery. While the European Society of Cardiology recommends hs‐TnT, American Cardiology and European anesthes...

Associations of leisure time and occupational physical activity with tobacco smoking and dual use of e-cigarettes among adults – a representative cross-sectional survey in Germany

Abstract Background Physical inactivity and tobacco smoking are risk factors for chronic diseases, and the combination of both further increase health risks. While leisure time physical activity (LTPA) improves cardiovascular health and is associated with lower smoking prevalence...