Heinrich Heine University Düsseldorf

P1.005. Preliminary Pilot Study Cohort Results - Cost-Effective Surveillance Strategies and Prediction of Cancer Recurrence After Endoscopic Therapy for Barrett’s Esophagus (Endeavor)

Abstract Topic Esophageal Cancer: Barrett‘s Esophagus: High-Grade Dysplasia and Early Invasive Cancer Background In many European countries, esophageal adenocarcinoma (EAC) incidence is increasing [1]. Barrett’s esophagus(BE), strongly associated with EAC, can progress via dyspla...

Investigating the role of serum IL-6 in predicting outcomes of b-cell depleting therapy in multiple sclerosis: a retrospective cohort study

Abstract Background Interleukin-6 (IL-6) plays a pivotal role in autoimmune inflammation through its effects on B-cell differentiation, Th17 expansion, and regulatory T-cell suppression. Given ocrelizumab’s (OCR) mechanism of selective CD20 + B-cell depletion, baseline IL-6 level...

Microvascular remodeling and endothelial dysfunction across the post-COVID-19 spectrum: a prospective observational case-control study

<title>Abstract</title> Background Post-viral diseases, including post-COVID-19 syndrome (PCS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), cause substantial long-term morbidity. Persistent cardiovascular risk after acute infection highlights the need for acce...

Rapid Two-StepMulticomponent Synthesis and Structure-degradationRelationships of Selective HDAC6 PROTAC Degraders

Abstract This work reports on the development of selective histone deacetylase 6 (HDAC6) degraders based on a peptoid scaffold. Structure-based design identified the isocyanide-derived cap region as suitable exit vector for linker attachment, enabling rapid generation of CRBN-rec...

Introducing Chlorido Cerium Complexes with the Methoxy Kläui Ligand [Co(η5-C5H5){P(O)(OMe)2}3]−

The treatment of Ce(OH)4 in thionyl chloride and dimethoxyethane (DME) resulted in the formation of a highly unstable red Ce(IV) complex with the composition [CeCl4(DME)2] (1). From the reaction of 1 with the Na[Co(η5-C5H5){P(O)(OMe)2}3] (NaLOMe) salt containing the anionic tripo...

Ultra-compact plasma photocathode in a hybrid wakefield accelerator

Abstract Plasma-based particle accelerators, realized by driving plasma waves with either an intense laser pulse or particle beam, offer accelerating fields orders of magnitude higher than conventional accelerators. This enables sources of highly relativistic electron beams with...

Curvature-induced smectic-C order of tangentially anchored hard spherocylinders on a sphere with a rigidly locked director field

We study the strict locked-orientation limit of hard spherocylinders on a sphere, in which the rod axes are rigidly locked to a prescribed tangential director field. The bulk hard-rod phase diagram contains no smectic-C (Sm-C) phase, so any coherent tilt found here is curvature-i...

Can parent–child interactions help reduce socioeconomic differences in language development? Results of a German birth cohort study

Abstract Aim Children from socioeconomically disadvantaged families often have lower developmental outcomes than their socioeconomically more advantaged peers. In early childhood, language development (LD) in particular is a key competence for further socialization. There is a ne...

Longitudinal progression, metrics, age-dependence, and modifiers of ataxia severity in SCA27B: a multicentre study of 219 patients

Background Spinocerebellar Ataxia 27B (SCA27B) is a novel, frequent and likely treatable late-onset autosomal-dominant ataxia caused by GAA repeat-expansions in FGF14 . For understanding disease evolution and imminent trial planning, metrics of the most widely used clinical outco...

The liver in diabetes: current state and future perspectives

Abstract Diabetes mellitus is strongly associated with metabolic dysfunction-associated steatotic liver disease (MASLD). For many years, MASLD has not been recognised as either a common pathophysiological feature of type 2 diabetes or a diabetes-related complication. This special...

Cardiac Opioid System and Its Role in Heart Failure and Ischemia–Reperfusion Injury

Opioid receptors and peptides act as modulators of cardiac and vascular function. These effects are mediated not only by central mechanisms but also via a local cardiac opioid system, which has gained increasing attention for its potential role in cardiovascular disease and perio...

Structure andRheology of DPPC–CholesterolMonolayers

Abstract Lipids are key components of biological interfaces and are constantly subjected to external stress and shear flow. In this work, we focus on DPPC–cholesterol monolayers at water–air interfaces and study their response to compression and shear. The choice of lipids is mot...

Prospective analysis of pre-diagnostic untargeted plasma metabolomics and risk of triple-negative breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Triple-negative breast cancer (TNBC) accounts for 10–15% of newly diagnosed breast cancer, and its aetiology is poorly understood compared to other breast cancer subtypes. We applied untargeted metabolomics to identify novel biological pathways associated with TNBC risk and poten...

Rab4b controls hepatic glucose production during fasting through glycophagy

Abstract Hepatic glucose production, essential for maintaining glycemia, is often altered in metabolic-associated fatty liver and glycogen storage diseases. Therefore, understanding the mechanisms that regulate the glucose production by hepatocyte is pivotal. Recent studies have...

Influence of dextran deswelling on graft preparation and clinical outcomes in DMEK

Abstract To evaluate the influence of dextran-containing versus dextran-free organ culture media on graft preparation characteristics and postoperative outcomes following Descemet Membrane Endothelial Keratoplasty (DMEK). In this single-center retrospective comparative study, 31...

Caregiver-reported experience of integrated care for children with special health care needs and its sociodemographic, health- and network-related correlates in Germany: Cross-sectional results from the PART-CHILD cohort

Abstract Background Children with special health care needs (CSHCN) often rely on cross-sectoral care networks involving medical, therapeutic, educational, and social services. However, key dimensions of integrated care, including cross-sectoral communication and attention to fam...

The World Psychiatric Association (WPA) Guideline on Schizophrenia Spectrum Disorders Management for Low- and Middle-Income Countries

There is a pressing need to address the unique challenges of managing Schizophrenia Spectrum Disorders (SSD) in Low- and Middle-Income Countries (LMICs), where mental health resources are scarce and unevenly distributed. To develop this evidence-based guideline, we conducted a sy...

DECIDER-2: Prospective randomized multicenter phase III trial of decitabine and venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy

Abstract Background Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of the combination of venetoclax (VEN) with azacitidine (AZA) or decitabine (DAC) in the European Union in 2021 for the treatment of patients wit...

The Impact of Psychosocial Factors on Pain and Functional Outcomes After Rotator Cuff Repair: A Systematic Review

Introduction Outcomes after rotator cuff repair are commonly evaluated in terms of structural healing and surgical technique. However, psychological factors may also influence patients’ experience of pain and functional recovery. Increasing attention has therefore been directed t...

MRI paving the way to diagnosis of acute lymphoblastic leukemia in children and adolescents – a retrospective observational study

BACKGROUND: Prompt diagnosis of childhood acute lymphoblastic leukemia (ALL) remains a clinical challenge, particularly in children presenting with normal blood counts and musculoskeletal symptoms. With the increasing use of magnetic resonance imaging (MRI) in evaluating such com...