Heinrich Heine University Düsseldorf

Incidence and Predictors of Complications After Transcatheter Aortic Valve Implantation According to VARC‐3 Criteria: A Systematic Review and Meta‐Analysis

BACKGROUND: Despite continuous advancements in devices and techniques, transcatheter aortic valve implantation remains associated with complications impacting outcomes. In 2021, the Valve Academic Research Consortium (VARC) introduced the VARC-3 criteria to better classify proced...

Hydrothermal origin of metabolic phosphorylation

Abstract Phosphate is central to modern bioenergetics and to all theories for the origin of life. How phosphate entered metabolism is unknown, though microbial physiology and geochemical environments can provide important clues. Some bacteria obtain electrons and energy from phos...

Insulin Resistance in the 21st Century: New Takes on an Old Problem—2025 Diabetes , Diabetes Care , and Diabetologia Expert Forum

Insulin resistance is a hallmark of type 2 diabetes and several other metabolic diseases. However, efforts to improve insulin resistance are hindered by the biological complexity inherent to insulin action, as well as conceptual and methodological limitations to date. In Septembe...

Insulin resistance in the 21st century: new takes on an old problem—2025 Diabetes, Diabetes Care, and Diabetologia Expert Forum

Insulin resistance is a hallmark of type 2 diabetes and several other metabolic diseases. However, efforts to improve insulin resistance are hindered by the biological complexity inherent to insulin action, as well as conceptual and methodological limitations to date. In Septembe...

Development of a monoclonal antibody targeting the calcification blocking factor CBF

Chronic kidney disease (CKD) patients suffer from a multitude of comorbidities, with vascular calcification being a major one. Recently, a new 19 amino acid long peptide, called calcification blocking factor (CBF), inhibiting vascular calcification has been identified. CBF concen...

Rheumatologists’ expectations and perceptions of T-cell redirecting therapies: results from a cross-sectional survey

Abstract T-cell redirecting therapies (TCRTs), including Chimeric antigen receptor (CAR)-T cells and T-cell engagers (TCEs), are emerging as transformative treatments for autoimmune diseases. However, clinical application is currently restricted to specialized centers, leaving mo...

Fecal Aβ and tau aggregates are elevated in cognitive impairment and reveal peripheral proteopathic alterations

Abstract Background Aggregation of amyloid-β (Aβ) and tau is central to Alzheimer’s disease (AD) pathogenesis and forms the basis of established cerebrospinal fluid (CSF) and imaging biomarkers. However, increasing evidence suggests that AD involves systemic processes beyond the...

The impact of physical activity and exercise timing on metabolic health among individuals at high risk of type 2 diabetes

The timing of physical activity and exercise has been suggested to play a role in metabolic health. This narrative review synthesises current evidence on the impact of habitual physical activity and exercise timing on glucose homeostasis and insulin sensitivity, blood lipids and...

Bilateral theta burst stimulation as an add-on to schema therapy in major depression: methods and design of a randomized, sham-controlled study

Abstract Schema therapy (ST) is an integrative psychotherapeutic treatment that may be as effective as cognitive behavioural therapy in treating depression. Novel approaches are focusing on augmenting psychiatric treatments with brain stimulation techniques, like repetitive trans...

Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network

Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially)...

Curriculum for Bioimaging Data Stewardship: A Systematic Review of Existing Training Resources

Abstract The increasing complexity and volume of biological imaging data require structured and sustainable research data management to ensure reproducibility, reusability, and compliance with FAIR (Findable, Accessible, Interoperable, and Reusable) principles. In this context, D...

Gender and other diversity-related factors in psychiatric hospital care: protocol for the participatory mixed-methods PSY-DIVER study

Psychiatric hospital care is multimodal and typically comprises pharmacotherapy, psychotherapy, social therapy, occupational therapy, exercise therapy, and various forms of creative therapies. The use, acceptance and effectiveness of these interventions may be shaped by gender an...

In situ visualization of autophagy reveals the presence of vesicles at the expanding phagophore rim

The autophagy core machinery mediates the enclosure of cytosolic cargo destined for degradation in the lysosome. The Atg9-Atg2-Atg18 complex coordinates phagophore expansion via directed lipid transfer until closure of the phagophore rim. Using an Atg2 variant (Atg2-PM4) as a mod...

Exploring work stressors and resources and their perceived effects on symptoms and work ability in employees with multiple sclerosis: a qualitative study

Abstract Background Adverse working conditions can lead to reduced working hours, career changes, or early exit from the workforce among employees with multiple sclerosis. The aim of the present study was to explore work-related stressors and resources, as well as their effects o...

From Closed to Mighty: How GTP-Induced Allosteric Dynamics, Dimerization, and Membrane Binding Transform a Bacterial Dynamin-like Protein

Abstract Dynamins, crucial GTPases involved in membrane remodeling, play key roles in processes like endocytosis and membrane fission. While their importance is well-established, the precise dynamics of their conformational changes remain unclear. This study investigates the bact...

Interferon-γ-response to mycobacterial glycopeptidolipids in patients with pulmonary non-tuberculous mycobacterial infection

Abstract The understanding of host responses to pulmonary infection with non-tuberculous mycobacteria (NTM) is incomplete and immunodiagnostic tools are not established. Unlike mycobacteria of the Mycobacterium tuberculosis complex, several NTM express glycopeptidolipids (GPLs) i...

Parental needs and experiences with e-Health applications in chronic pediatric care – a scoping review

Abstract Background The number of children and adolescents living with a chronic condition is steadily increasing. These conditions often place a considerable burden on affected individuals and their families. E-Health applications have the potential to support families by provid...

Changing the motivation for mental work with temporal interference stimulation

Successful goal-directed behavior often requires the exertion of effortful control processes. The striatum is thought to play a key role in determining whether a goal is worth the required cognitive effort, but whether and how the striatum causally influences effort-based decisio...

Changes in perceived psychosocial working conditions after psychotherapeutic consultation at work – exploratory post-hoc analyses from a randomized controlled trial

Abstract Background Psychotherapeutic consultation at work (PT-A) is a low-threshold intervention providing early work-focused treatment to employees with symptoms of common mental disorders (CMD). This post-hoc analysis explores whether PT-A, compared with routine care, is assoc...

Selected Papers from the 15th International Conference on Computational Heat and Mass Transfer (ICCHMT2025)

This Special Issue presents 12 papers selected from 15th International Conference on Computational Heat and Mass Transfer (ICCHMT2025).The ICCHMT conference series, which has been successfully orga...