Heinrich Heine University Düsseldorf

Effectiveness of an on-site vaccination campaign for patients with cancer

Abstract Background Patients with haematological or oncological malignancies are at increased risk of severe infections. Vaccination is a key preventive strategy and is recommended by National Immunization Technical Advisory Groups (NITAGs). Yet, vaccination rates in this populat...

Quality Assurance in Outpatient Psychotherapy

Abstract: Background: Between 2021 and 2023, we launched three quality assurance (QA) projects to establish a secure, clinically useful, and easily implementable QA system for (1) adult psychotherapy patients in (a) outpatient training clinics and (b) private practice and (2) chi...

Systemic Metabolic Changes in Plasma of Patients with Myelodysplastic Neoplasms and Chronic Myelomonocytic Leukemia

Background: Myelodysplastic neoplasms (MDSs) are clonal hematopoietic stem cell disorders associated with ineffective hematopoiesis, chronic inflammation, and increased cardiovascular morbidity. Although metabolic dysregulation has been implicated in MDS pathogenesis, systemic me...

Photophysics of Angelicin─The Simplest Angular Furocoumarin

Abstract Angelicin (ANG) is the simplest angular furocoumarin. It undergoes photoinduced DNA monoadduct formation and does not form interstrand cross-links, resulting in photobiological behavior distinct from that of its linear analogues (psoralens). Here, the photophysics of ANG...

Evolving transition-state search with agentic large language models

Abstract Accurate identification of transition states (TSs) is fundamental to computational chemistry. Modern reaction-discovery efforts increasingly rely on curating and completing large reaction datasets, where even a small fraction of TS-search failures can leave key pathways...

Machine learning analysis of COVID-19 transmission dynamics demographic risk and contact tracing outcomes in Nigeria

Abstract The COVID-19 pandemic has posed significant challenges to developing countries like Nigeria due to limited resources. Accurate prediction of disease spread is crucial for effective containment measures. This study investigates the application of statistical and machine l...

A multicenter analysis of prognostic factors for patients undergoing re-irradiation for recurrent glioblastoma

Abstract Background Re-irradiation (re-RT) has gained popularity in the treatment of recurrent or progressive glioblastoma (rGBM) after first-line treatment. However, uncertainties regarding optimal treatment dose, fraction size and target volume definition remain. In this multic...

Cullin 3 ubiquitin ligase regulates redox defense and metabolic programs in proximal tubule cells

Abstract Background Chronic kidney disease (CKD) is characterized by proximal tubule (PT) stress, oxidative injury, and metabolic dysfunction. Human kidney single-nucleus RNA-sequencing (snRNA-seq) identified enrichment of ubiquitin-dependent protein catabolic processes in injure...

A Fully Discrete Truly Multidimensional Active Flux Method for the Two-Dimensional Euler Equations

Abstract. The active flux method is a finite volume method for hyperbolic conservation laws that uses both cell averages and point values as degrees of freedom. Several versions of such methods are currently under development. We focus on third order accurate, fully discrete acti...

Dystonia 3×3: A Training Guideline for Beginners in Botulinum Neurotoxin Treatment of Cervical Dystonia

Cervical dystonia (CD) is a hyperkinetic movement disorder characterized by involuntary muscle contractions leading to abnormal postures of the head and neck. The injection of botulinum neurotoxin type A (BoNT-A) into the muscles involved is the treatment of choice for CD. BoNT-A...

Multiscale characterization of cortical signatures in positive and negative schizotypy:a worldwide ENIGMA study

Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurodevelopmental and schizophrenia-spectrum pathologies. Yet, a comprehensive characterization of the unique and shared neuroanatomical signatures of these...

Timing of PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation

BackgroundApproximately one half of patients undergoing transcatheter aortic-valve implantation (TAVI) have concomitant coronary artery disease. Although percutaneous coronary intervention (PCI) is often performed before TAVI, the preferred treatment strategy has not been establi...

Charting Endocrine Progenitors Across Species and Organs

ABSTRACT Hormone‐producing cells in the pancreas and intestine regulate whole‐body metabolism and are dysregulated in obesity and diabetes. A deeper understanding of endocrine lineage formation (endocrinogenesis) in these organs is essential to elucidate the healthy state and dis...

A Distant Reading Model of Intersectional Identity in Fiction: What Constitutes Character in the Early Modern Yiddish Romance Bovo d’Antona?

Abstract This article illustrates how distant reading methods that take an intersectional approach to fictional identity in medieval and early modern texts can shed new light on the identity models being hailed in these texts. To this end it discusses and contextualises the resul...

Designing a School-Based, Complex Public Health Intervention to Improve Iodine Awareness in Adolescents in Six Countries

Background: Iodine is an essential micronutrient required for foetal development, cognitive function, and metabolic regulation; however, suboptimal iodine status remains a public health concern in Europe and other regions. Improving food literacy related to iodine may support hea...

A targetable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer

Abstract Small cell lung cancer (SCLC) is one of the most aggressive malignancies, characterized by rapid metastatic dissemination and poor overall survival. Despite harboring excessive alterations, expectedly resulting in immunogenic neoantigens, patients with SCLC remain largel...

Maximal subgroups in torsion branch groups

We study the maximal subgroups of branch groups and obtain a criterion that ensures that certain spinal groups are contained in the class \mathcal{MF} of groups with all maximal subgroups of finite index. This allows us to construct branch groups within \mathcal{MF} exhibiting no...

P1.005. Preliminary Pilot Study Cohort Results - Cost-Effective Surveillance Strategies and Prediction of Cancer Recurrence After Endoscopic Therapy for Barrett’s Esophagus (Endeavor)

Abstract Topic Esophageal Cancer: Barrett‘s Esophagus: High-Grade Dysplasia and Early Invasive Cancer Background In many European countries, esophageal adenocarcinoma (EAC) incidence is increasing [1]. Barrett’s esophagus(BE), strongly associated with EAC, can progress via dyspla...

Investigating the role of serum IL-6 in predicting outcomes of b-cell depleting therapy in multiple sclerosis: a retrospective cohort study

Abstract Background Interleukin-6 (IL-6) plays a pivotal role in autoimmune inflammation through its effects on B-cell differentiation, Th17 expansion, and regulatory T-cell suppression. Given ocrelizumab’s (OCR) mechanism of selective CD20 + B-cell depletion, baseline IL-6 level...

Microvascular remodeling and endothelial dysfunction across the post-COVID-19 spectrum: a prospective observational case-control study

<title>Abstract</title> Background Post-viral diseases, including post-COVID-19 syndrome (PCS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), cause substantial long-term morbidity. Persistent cardiovascular risk after acute infection highlights the need for acce...