Harvard University

Fatal Neuroinvasive Astrovirus VA1 Encephalitis in a Child With High‐Risk B‐ALL Receiving Blinatumomab

O.L. is a named inventor on patents held by Boston Children's Hospital related to vaccine adjuvants and antigens as well as human in vitro systems that model the safety and immunogenicity of vaccines and immunotherapeutics. O.L.’s laboratory receives sponsored research support fr...

Cardiovascular Risk Prediction with the Kidney Failure Risk Equation in the Chronic Renal Insufficiency Study

Background: The Kidney Failure Risk Equation (KFRE) is an established tool to predict the risk of kidney failure among patients with CKD. Patients with CKD more often die from cardiovascular (CV) causes than renal causes, and more often experience a non-fatal CV event than progre...

Inhibition of RhoA-mediated secretory autophagy in megakaryocytes mitigates myelofibrosis in mice

Abstract Megakaryocytes (MKs) are large, polyploid cells that contribute to bone marrow homeostasis through the secretion of cytokines such as transforming growth factor β1 (TGFβ1). During neoplastic transformation, immature MKs accumulate in the bone marrow where they induce fib...

A joint geophysical-geochemical deep-mantle zoning map beneath East Africa and the Indian Ocean

Geochemical signatures of hotspot lavas suggest that their mantle sources are compositionally distinct, but their source locations remain elusive. Mapping hotspots to their deep origins is complicated by the presence of interconnected, low–seismic velocity networks in the mantle,...

Focal Therapy for Prostate Cancer

This retrospective study uses data from the National Cancer Database to examine patterns and temporal trends in use of focal therapy for prostate cancer in US cancer centers; characterize inappropriate use in low-, high-, or very–high-risk disease; and describe intermediate-risk...

Platelet Reactivity and Sex Differences: Clinical Implications for Women

Platelets are central to hemostasis and thrombosis. Excessive platelet activation contributes to arterial thrombotic events, including myocardial infarction, ischemic stroke, and complications of peripheral artery disease, whereas excessive platelet inhibition increases bleeding...

Longitudinal Quantitative Mapping of Meniscal Morphological and Signal Intensity Differences After ACL Surgery

BACKGROUND: Meniscal tears are frequently associated with anterior cruciate ligament (ACL) injuries. Evaluating longitudinal changes in meniscal integrity using quantitative magnetic resonance imaging after ACL surgery may provide valuable insight into joint recovery and subseque...

Gestational Diabetes Mellitus: Recurrence and Future Type 2 Diabetes Risk Across Racial and Ethnic Groups

OBJECTIVE Despite rising diabetes prevalence among women, data on long-term diabetes risk following gestational diabetes mellitus (GDM), particularly its recurrence, remain limited, especially for Asian women. This study examined associations among GDM, its recurrence, and subseq...

Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combination therapy strategies in pancreatic cancer

Abstract Daraxonrasib is an orally bioavailable RAS(ON) multi-selective tri-complex inhibitor of the oncogenic mutant and wild-type variants of N, H and KRAS. We previously reported encouraging efficacy in a phase 1/2 clinical trial evaluating daraxonrasib monotherapy at clinical...

‘Talk CKD Options’: improving how clinicians communicate treatment options in advanced kidney disease using a conversation analysis-based training intervention

Abstract Background Most older people with kidney failure and multiple co-morbidities must decide between dialysis or conservative kidney management. Dialysis is often presented as the default, despite providing uncertain survival benefits in this population. The Optimising Staff...

Beyond ‘diagnostic error’: an ethnography of resilient behaviours and system adaptations in paediatric outpatient diagnosis

Background Improving paediatric diagnosis by addressing errors (Safety-I) is insufficient for diagnostic excellence. Resilience engineering’s approach to understanding adaptations to achieve success in everyday work may elucidate how individuals and systems manage diagnostic comp...

Rural-Urban Disparities in Contemporary Systemic Therapy for Advanced Prostate Cancer

This cross-sectional study examines the associations of rural-urban residence and race with receipt of systemic therapy for advanced prostate cancer.

Pitfalls of announcing regulatory policy in medical journals

<b>Sean Tu</b> and <b>Aaron Kesselheim</b> argue that sidestepping established administrative processes to announce major regulatory policies undermines transparency, public participation and trust, and regulatory legitimacy

Developing Consensus Using the Delphi Method

The Delphi method is a technique for obtaining consensus from a panel of experts on a particular topic or set of decisions, such as diagnostic or treatment algorithms, medical education competencies, or curricular components. This article aims to introduce researchers new to cons...

Environmental exposure to semi-volatile organic compounds and COPD progression: Evidence mapping, exposure assessment and metabolomic insights

Introduction Chronic obstructive pulmonary disease (COPD) progression may be influenced by non-smoking environmental exposures, especially among never-smokers and environmentally exposed populations. Semi-volatile organic compounds (SVOCs) are relevant because they persist in air...

Resident-led Board Review-focused Didactics Improve Physiatry Self-assessment Examination Scores

We implemented an educational intervention centered on resident-led, board review-focused didactics to improve Self-Assessment Exam for Residents (SAE-R) scores at our institution, carried out over two academic years (2024-2025 and 2025-2026). As a result, mean percentile scores...

Modeling effective doses of therapeutic antibodies targeting clustered surface receptors

Abstract A longstanding practice for therapeutic dosing of monoclonal antibodies is to identify the maximally tolerated dose. However, this approach has encountered limited success with some antibodies, especially in failed cancer trials. Here we report on an alternative dose-fin...

Evaluating the costs of developing a digital supervision tool for task-shared depression care: findings from a multi-site study in India

BACKGROUND: Task-sharing with non-specialist providers offers a promising solution to the mental health workforce shortage in low-resource settings. Supervision is essential to ensure treatment quality, but is often constrained by limited specialist availability. AIMS: This study...

Advocacy around abortion in a politically charged climate

PURPOSE OF REVIEW: To examine the evolving role of clinician advocacy in abortion care and to highlight key domains through which obstetrician-gynecologists can influence policy, clinical practice, and patient outcomes. RECENT FINDINGS: Increasing state-level abortion restriction...

Cannabinoids suppress chemotherapy- and ionizing radiation-induced apoptosis of glioblastoma cells

Abstract Cancer patients are increasingly exposed to cannabinoids, the bioactive molecules produced by the Cannabis sativa La. plant. This trend is being driven by several factors: expanding cannabis legalization, FDA approval of select cannabinoids for the treatment of seizures...