Harvard University

Development of a PEGylated parylene nanopocket membrane for the capture and release of lipid vesicles

Membranes are commonly used for the separation and purification of a variety of biological species. In this study, we developed a nanopocket membrane that can capture nanoparticles and extracellular vesicles in tangential flow filtration by pulling the species of interest into a...

Variation in In-Hospital Emergency Transfer Rates Across Pediatric Hospitals

BACKGROUND: Clinical deterioration with late escalation, termed emergency transfer (ET), is a key safety metric. However, national benchmarking is limited by variable definitions. We sought to estimate pooled ET rates and assess variation across pediatric hospitals. METHODS: We p...

Importance of Global Health Opportunities in Residency Selection Among Otolaryngology Applicants

ABSTRACT Introduction Global health has become an increasing priority in medical training. In this cross‐sectional study, we seek to evaluate the importance of a residency program's global health opportunities on otolaryngology‐head and neck surgery (OHNS) applicants' residency s...

An explainable biomedical foundation model via large-scale concept-enhanced vision–language pretraining

Artificial intelligence for medical imaging is required to be accurate and interpretable to clinicians. However, current multimodal biomedical foundation models often prioritize performance over explainability. Here we present ConceptCLIP, an explainable biomedical foundation mod...

Superconductivity from doping symmetric mass generation insulators: application to La3Ni2O7 under pressure

Abstract We investigate the bilayer nickelates as a platform to realize the symmetric mass generation (SMG) insulator, a featureless Mott insulator that arises due to the Lieb-Schultz-Mattis (LSM) anomaly cancellation in bilayer spin-1/2 lattice systems. Through a single-orbital...

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patients annually despite adequate therapy. The mechanisms underlying these events rem...

Opening editorial for the BMC Anesthesiology collection: recent advances in anesthesia for congenital cardiac diseases

Congenital cardiac anesthesia has evolved substantially over recent decades, contributing to improving outcomes and survival for patients with congenital heart disease (CHD). BMC Anesthesiology has initiated a new Collection, Recent Advances in Anesthesia for Congenital Cardiac D...

Perspectives on Meditation-based Preparation for Psychedelic Experiences: Insights from Practitioners with Combined Meditation and Psychedelic Experience

Abstract Objectives Emerging research suggests that meditation may support more beneficial psychedelic experiences while reducing the likelihood of lasting negative effects, yet its specific preparatory benefits remain underexplored. This study aimed to investigate the perceived...

A communication and messaging framework to increase public awareness of ultra-processed foods in Australia

Abstract Background Evidence of the health, environmental, and broader societal impacts of ultra-processed foods (UPFs) is rapidly accumulating, yet public awareness remains limited. This study aimed to develop a communication and messaging framework to increase public awareness...

The extreme diversity of retinal amacrine cells has deep evolutionary roots

Amacrine cells (ACs) comprise a heterogeneous class of inhibitory neurons in the vertebrate retina, exhibiting morphological and functional complexity rivaling that of cortical interneurons. Here, we integrate single-cell and single-nucleus transcriptomic atlases from 24 vertebra...

Dental Care as a Test Case for Rural Health Reform

This Viewpoint uses dental care as a test case for whether rural health care reform translates into more reliable access.

Paternal Exposure to Endocrine Disrupting Chemicals and Couples’ Pregnancy Outcomes: A Qualitative Review of the Literature

Abstract Purpose of Review Endocrine-disrupting chemicals (EDCs) are ubiquitous, and exposure to them has been associated with adverse reproductive health in both animals and humans. While the adverse effects of maternal EDC exposures on pregnancy outcomes have been extensively i...

Proliferative control of the saccular-stage developing mouse lung requires the histone methylation activity of KMT2D

KMT2D, the histone methyltransferase and core component of the COMPASS/MLL4 complex, has been implicated in developmental diseases such as Kabuki Syndrome, interstitial lung disease, and congenital diaphragmatic hernia, with clear links to pediatric pulmonary disorders. Despite t...

The role of biomarkers across the care continuum in acute heart failure

Acute heart failure (AHF) remains a global health challenge, characterized by high morbidity, mortality, and frequent rehospitalizations. The heterogeneity of clinical presentations in AHF and its complex underlying pathophysiology complicates diagnosis, risk stratification, and...

Apical extracellular matrix development

The apical extracellular matrix (aECM) plays crucial roles during morphogenesis and forms the interface through which tissues communicate with the environment. The aECM exhibits complex molecular composition and structure, including multi-layered organization, localized cell-type...

Splicing genes as main targets of differential splicing

Abstract Splicing of transcripts via the spliceosome machinery is a complex process involving a multitude of proteins and short noncoding RNAs. In addition to full-length transcripts with all exons in the genomically encoded order, alternatively spliced transcripts can also be pr...

Scanning X-ray microdiffraction studies of protein accumulation and tissue loss in thin sections of human brain tissue in Alzheimer’s disease

Neurodegeneration in Alzheimer's disease is characterized by accumulation of pathological protein deposits including Aβ plaques, tau tangles and diffuse neuropil threads accompanied by wide-spread tissue loss. While dense protein deposits are readily observed by conventional meth...

Data-driven prediction of fifteen-year all-cause mortality among 2.3 million individuals in the VA

ABSTRACT We present a data-driven framework to predict 15-year all-cause mortality using outpatient administrative records for 2.3 million Veterans in the largest integrated U.S. healthcare system. Rather than relying on predefined clinical phenotypes, we used the 1,000 most comm...

Integrating mental health support into care for placenta accreta spectrum: a qualitative analysis of patient perspectives

Abstract Background Patients with high-risk pregnancies due to placenta accreta spectrum (PAS) are at high risk of morbidity and mortality, which may increase risk for childbirth related mental health sequelae including postpartum post-traumatic stress disorder (PTSD) and trauma...

Psychoactive Medication Prescribing After Critical Illness in American Adults Not Justified by a Documented Supporting Diagnosis

Objectives: To describe psychoactive medication (PM) prescribing in the 30 days after an ICU admission requiring mechanical ventilation not supported by a documented diagnosis in American adults not prescribed a PM before ICU admission. This nondiagnostically supported PM prescri...