Harvard University

Inflammatory Breast Cancer-Related Lymphedema

Background: Breast cancer-related lymphedema (BCRL) is a potentially debilitating outcome following breast cancer treatment. Much attention has been given to preventive and curative strategies for BCRL. Patients with inflammatory breast cancer (IBC) are at particularly increased...

Intact Visual Correlation Detection in Autistic Adults

The ability to detect recurring temporal co-occurrence, or temporal correlation, of sensory events is fundamental for organizing perceptual input into coherent representations. Although past work has revealed differences across several aspects of temporal processing in autism, it...

Childhood‐Onset Movement Disorders at the Forefront: From Genes to Precision Therapy

Data sharing not applicable to this article as no datasets were generated or analysed during the current study. Disclosure Form Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other...

Individualized statin associated type 2 diabetes risk estimation with a deep causal model

Statin therapy reduces cardiovascular risk, but recorded statin exposure is associated with subsequent type 2 diabetes (T2D) in some populations. Individualized risk estimation and separation of low-density lipoprotein cholesterol (LDL-C)-mediated from non-LDL components remain c...

Effect of time to palliative epilepsy surgery on outcomes

Abstract Objective Epilepsy duration is a modifiable risk factor in the outcome of definitive epilepsy surgery; however, an analogous effect in palliative procedures has not been shown. We reviewed the Pediatric Epilepsy Surgery Database data for an association between epilepsy d...

Neddylation of NFATc1 and Runx2 regulates osteoclast–osteoblast balance and represents a dual-action therapeutic target for postmenopausal osteoporosis

Postmenopausal osteoporosis (PMOP) arises from a bone remodeling imbalance in which osteoclast-mediated resorption exceeds osteoblast-driven formation. However, current therapies primarily target osteoclasts without restoring osteoblast function, underscoring the need for mechani...

Patient engagement, acceptability, and preference of artificial intelligence versus human coaching for diabetes prevention

Artificial intelligence-powered lifestyle interventions may expand access to behavioral change support, but patient experience remains critical to real-world uptake and effectiveness. In a phase 3 randomized clinical trial of adults with prediabetes and overweight or obesity ( N...

Diabetic and ER-stressed pancreatic islet β cells are in need of some JNK removal

Pancreatic β cells regulate glucose homeostasis through insulin secretion, but nutrient overload and genetic defects can trigger ER stress and apoptosis, contributing to type 2 diabetes. Within β cells, the kinases PERK, IRE1α, and ATF6 initiate the unfolded protein response (UPR...

A systematic review of environmental factors in AI-based fall risk prediction models for community-dwelling older adults

Falls commonly occur in home environments, where conditions can increase fall risk. Identification and mitigation of environmental hazards are critical components of fall prevention. However, artificial intelligence (AI)-based fall prediction models have largely focused on indivi...

Cost‐Effectiveness of Radiofrequency Ablation for Benign Non‐Functioning Thyroid Nodules: A Systematic Review

ABSTRACT Purpose This systematic review tests the hypothesis that radiofrequency ablation (RFA) for benign non‐functioning thyroid nodules is associated with favourable cost‐effectiveness compared with surgery. Materials and Methods A systematic literature search of multiple data...

Flumazenil Use in Benzodiazepine-Induced Delirium Reversal.

Delirium is a frequent and serious complication in critically ill patients, associated with increased mortality, prolonged hospitalization, and long-term cognitive impairment. The hypoactive subtype is particularly underrecognized, missed in up to 75% of cases, and carries worse...

Shotgun Metagenomics Identify Unique Changes of the Intestinal Microbiome in Pediatric Survivors of Acute Lymphoblastic Leukemia.

BACKGROUND: Intestinal microbiota plays an important role in human health and metabolism. Microbial dysbiosis has been observed in various chronic conditions, many of which are late effects of leukemia treatment. We previously observed significant differences in the gut microbiom...

High-throughput engineering of bispecific antibodies to enhance macrophage-mediated cytotoxicity of B-cell lymphoma

Abstract Macrophages are critical effectors of antibody therapies for lymphoma, but the best targets to engage their function remain unknown. Here, we develop a ‘tactical surfaceome profiling’ strategy to define a comprehensive repertoire of surface antigens on B-cell lymphoma th...