Harvard University

Health insurance in Nigeria: Findings from the People’s Voice Survey

Abstract The recent Lancet Commission on Nigeria’s health system highlighted high out of pocket expenditures on health and underfunding of the public health sector as major obstacles to Nigeria’s achievement of the Sustainable Development Goals. Nigeria has sought to address thes...

JNK signaling regulates reproductive trade-offs after Plasmodium infection in the malaria mosquito

ABSTRACT Environmental stress can limit mammalian reproduction by affecting production of sexual steroid hormones. Here we reveal a similar mechanism in the malarial mosquito Anopheles gambiae : activation of the stress-sensitive c- J un N -terminal k inase, JNK, constrains repro...

Longitudinal alignments and syntheses of multimodal clinical data for personalized medicine with the PULSE framework

Multimodal models capable of imputing diverse data used in single-cell biology studies provide potential foundational opportunities in clinical practice. However, patient data uniquely comprise longitudinal mosaic measurements that reflect underlying physiological dynamics and ex...

Reconstruction of epithelial transcriptional trajectories reveals heterogeneous progression and early therapy-resistance programs in high-grade serous carcinoma precursors

Abstract Background Serous-tubal intraepithelial-carcinoma (STIC) is considered the principal precursor of tubo-ovarian high-grade serous-carcinoma (HGSC), yet its biological uniformity, progression risk and potential response to poly(ADP-ribose) polymerase-inhibitors (PARPi) rem...

In a nutshell: Haematological immune‐related adverse events

Summary The use of immune checkpoint inhibitors (ICIs) have transformed oncological care. In this ‘nutshell review’, we summarize the most common haematological immune‐related adverse events (irAEs) associated with checkpoint inhibitors. We also outline management strategies and...

“I Know Far More Dead People Than I Do Live Ones”: Social Isolation Among Older Adults Who Use Stimulants

BACKGROUND: Social isolation is associated with poor physical health and premature mortality. Midlife and older adults who use stimulants (cocaine or methamphetamine) may be especially vulnerable to social isolation. METHODS: We conducted in-depth semi-structured interviews with...

Farnesyltransferase Enables Modular Assembly of Dual‐Functional Nanobody Conjugates for in Vivo Imaging of Inflammation

ABSTRACT Non‐invasive imaging of inflammation is critical for disease diagnosis, monitoring, and therapeutic evaluation. Nanobodies, due to their many unique properties, are emerging as powerful imaging agents; however, conventional non‐specific conjugation strategies often yield...

Gut microbiome–metabolome interactions during varied low-carbohydrate food consumption

Low-carbohydrate (LC) foods have been associated with weight loss, insulin resistance, and reduced inflammation. Gut microbes may drive these effects by changing the host’s immune and metabolic state, yet the optimal replacement strategies (e.g., protein vs. fat) and the biochemi...

Navigating physician-scientist careers: insights from American Board of Internal Medicine Research Pathway graduates

The American Board of Internal Medicine Research Pathway (ABIM RP) is designed to train physician-scientists by shortening postgraduate clinical training and increasing research time. We surveyed ABIM RP graduates to understand career trajectories, research engagement, and barrie...

Global Reach of the EU 's CSRD : How Sustainability Disclosure Mandates Affect Non‐ EU Firms

ABSTRACT The European Union's Corporate Sustainability Reporting Directive (CSRD) represents a landmark regulatory effort to enhance global sustainability reporting and corporate accountability. This study examines how CSRD affects non‐EU firms with substantial economic exposure...

MitoGPS: A Mitochondrial DNA G‐Quadruplex‐Targeting Strategy for Tumor‐Preferential Type I Photodynamic Therapy

ABSTRACT Photodynamic therapy (PDT) is a clinically promising, minimally invasive cancer treatment offering precise spatiotemporal control. However, achieving preferential tumor accumulation remains a critical challenge, which limits therapeutic efficacy and induces off‐target to...

Automated alveolar bone and teeth 3D segmentation on the cone-beam computed tomographic images using the convolutional neural network

Abstract Background Cone-beam computed tomography (CBCT) is widely used in dental diagnosis and implant planning. The accurate segmentation of teeth and alveolar bone from CBCT images is essential for precise diagnosis and treatment planning. In this study, we propose two distinc...

The effects of royal jelly consumption on glycemia indices, lipid profile, and blood pressure in patients with acute ischemic stroke: a randomized, triple-blind trial

Abstract Aims The effects of royal jelly (RJ) on cardiometabolic risk factors in patients with acute ischemic stroke have not been previously reported from this trial. Therefore, we conducted a secondary analysis to investigate the effects of RJ consumption on glycemic indices, l...

Early gastric carcinoma with lymphoid stroma associated with a low risk of lymph node metastasis and favorable prognosis: a multicenter study in a Chinese population

Abstract Objective Gastric carcinoma with lymphoid stroma is a rare subtype of gastric carcinoma. The clinicopathological features and prognosis of early gastric carcinoma with lymphoid stroma (EGCLS) remain elusive, especially in Chinese populations. Methods In this study, we in...

Quantifying the Acute Toxicity of Alpha-Synuclein Membrane-Accumulation in a Cell-Based Assay

Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects over 12 million people worldwide. A central pathological feature is the accumulation of aggregated alpha-synuclein (αS) in Lewy bodies and Lewy neurites. Engineered αS variants such as 3K (...

Longitudinal digital phenotyping of activity rhythms and biological aging using commercial wearables

Abstract Disrupted rest-activity rhythms have been associated with aging and chronic disease, yet longitudinal evidence from free-living populations has been lacking. Here we integrate multi-year Fitbit activity data from the All of Us Research Program with clinical biomarker-der...

Management of Acute Pulmonary Embolism in a Patient With Hereditary Factor X Deficiency

All authors declare that they have no conflicts of interest. The data that support the findings of this study are available from the corresponding author upon reasonable request.

Prediagnostic circulating 25-hydroxyvitamin D and prostate cancer-specific survival: a collaborative pooled analysis of 13 prospective studies

Abstract Background Previous research suggests higher risk of prostate cancer diagnosis in men with high vitamin D serology, but there are limited data related to prostate cancer survival. In this study, we examine the associations between prediagnostic circulating levels of 25-h...

“I Just Need Guidance Through This Maze I’m Going Through”: Addressing Unmet Basic and Mental Health Needs to Facilitate Engagement in HIV Prevention Services in the Context of Stimulant Use

There is a global syndemic of HIV, mental health challenges, substance use, and structural barriers. Critical to local HIV prevention efforts is understanding this syndemic in the context of rising stimulant use to inform intervention development. Adhering to the EPIS model, we c...

A comparative “report card” wellbeing assessment of 22 countries in the Global Flourishing Study

When evaluating how countries are faring, there is a widespread tendency to rely on single metrics or indices, whether objective (e.g., GDP) or subjective (e.g., life evaluation). However, flourishing is multidimensional, and societies invariably do better in some ways and less s...