Fujian Medical University

Metal artifact reduction sequence MRI in hip periprosthetic joint infection management

Aims: There is currently no validated noninvasive method to determine infection control prior to prosthesis reimplantation during the two-stage revision process for hip periprosthetic joint infections (PJI) after total hip arthroplasty (THA). This prospective study investigates w...

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Application of CNV-seq combined with chromosome karyotyping in prenatal diagnosis of pregnant women with high-risk NIPT results

Non-invasive prenatal testing (NIPT), which utilizes fetal cell-free DNA (cffDNA) in maternal peripheral blood to assess the risk of fetal chromosomal abnormalities, has been widely used for prenatal screening. Chromosome karyotyping and low-depth whole-genome copy number variati...

Effects of post drill specification, preparation depth and adjacent tooth status on the scanning trueness of post space: an in vitro study

Abstract Background The indication for direct intraoral scanning of post spaces should be guided by the post drill. This study evaluated the influence of drill specifications, preparation depth, and the presence or absence of bilateral adjacent teeth on the scanning trueness of p...

Malaria burden across 126 tropical countries and territories, 1990–2021: tropical-climate share, sociodemographic correlates, population dynamics, and projections to 2050

Malaria remains a major global health challenge, particularly in tropical regions. Although recent global reports describe persistent malaria burden, fewer studies have jointly assessed tropical-climate context, sociodemographic development, demographic decomposition, and future...

Subdivision of metachronous metastatic nasopharyngeal carcinoma based on the framework of TNM-9: A recursive partitioning analysis of real-world data

Abstract Purpose: To validate the prognostic value of the M1 category in version nine of the AJCC/UICC TNM staging system (TNM-9) in metachronous metastatic nasopharyngeal carcinoma (mmNPC) and to develop a refined M1 classification for improved risk stratification. Methods: Pati...

Longitudinal plasma phosphorylated tau217 classification and the association with Alzheimer's disease progression

Abstract INTRODUCTION Longitudinal diagnostic and prognostic validity of plasma phosphorylated tau217 (p‐tau217) in Alzheimer's disease (AD) remains uncertain. METHODS In this multi‐cohort study of 2117 individuals, we established baseline plasma p‐tau217 thresholds for amyloid‐β...

The unbalanced needs and perceived supply of supportive care in family caregivers of patients with multiple myeloma: a cross-sectional study

Abstract Background Understanding the needs of family caregivers of patients with cancer and providing appropriate support are essential to ease the burden of illness, facilitate family management, and reduce the risk of adverse health outcomes. Currently, the unmet supportive ca...

Establishment of an enteral nutrition pathway for malignant esophageal obstruction using combined esophageal stenting and gastrostomy

Malnutrition is common in patients with advanced esophageal cancer and is associated with poor outcomes. While esophageal stenting can relieve dysphagia, oral intake alone is often insufficient. Percutaneous endoscopic gastrostomy (PEG) provides reliable nutritional support but d...

Mechanistic investigation of keratinocyte injury induced by the small-molecule PD-L1 inhibitor BMS-1 via network toxicology, molecular dynamics simulation and cellular assays

Abstract Background Programmed cell death ligand 1 (PD-L1) inhibitors are important agents for lung cancer immunotherapy. However, they frequently cause cutaneous toxicity in clinical practice, which compromises therapeutic compliance. Current studies mostly focus on immune cells...

Mental disorders as a predictor of incident edentulism: a prospective cohort study

Edentulism represents the terminal stage of cumulative oral disease and is a key indicator of oral health deterioration in aging populations. Although individuals with mental disorders are recognized as a high-risk group for poor oral health, longitudinal evidence linking mental...

TRIM22 promotes K48-linked ubiquitination of LDHA, leading to the inhibition of HBV replication

Hepatitis B virus (HBV) infection and its related liver diseases remain a major worldwide public health problem, its mechanism hasn't fully clarified. While our previous work identified TRIM22 as an interferon-stimulated gene that suppresses HBV replication via innate immune path...

Non-linear associations of plasma 25-hydroxyvitamin D with serum homocysteine and hyperhomocysteinemia in Chinese adults: a cross-sectional study

Abstract Background Plasma 25-hydroxyvitamin D [25(OH)D] deficiency and elevated homocysteine (Hcy) levels are both well-established risk factors for cardiovascular disease (CVD). However, the relationship between 25(OH)D and Hcy remains unclear. To explore the association betwee...

Citation landscape and research themes of robotic-assisted total hip arthroplasty: a bibliometric analysis of the 100 most-cited English-language publications in the Web of Science Core Collection

Robotic-assisted total hip arthroplasty (ra-THA) has received increasing academic attention. This bibliometric study aimed to identify the 100 most-cited English-language articles related to ra-THA indexed in the Web of Science Core Collection (WOSCC) and to characterize their ci...

Biological age acceleration and mortality risk among U.S. adults with cardio-kidney-metabolic syndrome, stages 0–3

This study aims to evaluate the associations of Klemera-Doubal Method Biological Age Acceleration (KDM-BAA) and Phenotypic Age Acceleration (PAA) with all-cause and cause-specific mortality in U.S. adults with Cardio-Kidney-Metabolic (CKM) syndrome stages 0–3 and to establish ris...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Prospective association between cumulative average grip strength and successful aging: evidence from the CHARLS, ELSA and SHARE multi-cohort study

Global population aging is accelerating, making successful aging a key public health goal. Grip strength, a functional biomarker, may reflect long-term muscle function and influence successful aging. Prior studies were limited by single-point exposure measurement and cross-popula...

The influence path of the homogenization management level of medical services in county-level medical communities on the medical service capabilities of township health centers

Abstract Objective This study elucidates the relationship between the level of homogeneity management in county-level community healthcare services and the medical service capacity of township health centers. and constructs an influence path model. It aims to promote the coordina...

Postoperative surveillance strategy in patients undergoing neoadjuvant chemoradiotherapy followed by curative resection for locally advanced rectal cancer

Abstract Background There are no consistent recommendations for postoperative surveillance intervals for rectal cancer in the major guidelines. Knowledge about recurrence hazards can help develop appropriate surveillance schedules. This study aimed to investigate transitions in r...