Fujian Medical University

Dynamic cardio-renal-metabolic trajectories identify sepsis subphenotypes for individualized management: a cross-population cohort study

Sepsis heterogeneity remains a major barrier to precision medicine. Although cardio-renal-metabolic interactions critically influence outcomes, their dynamic evolution is rarely integrated into clinical phenotyping. We aimed to identify distinct sepsis subphenotypes based on dyna...

Bioactive PCL/nSi-BMSCs composite scaffold regulates periosteal cell functions for neurovascularized bone regeneration

Proper innervation and vascularization are not only essential for maintaining bone homeostasis but also play a pivotal role in orchestrating efficient bone regeneration. Here, we investigate the regenerative potential of a polycaprolactone/Nanosilicates (PCL/nSi) scaffold loaded...

Autism spectrum disorder burden in China and worldwide, 1990–2021

Autism spectrum disorder (ASD) imposes a substantial public health burden. This study quantified and compared the ASD burden in China and globally from 1990 to 2021 to inform policy and planning. We analyzed Global Burden of Disease 2021 estimates of age-standardized prevalence r...

Arterial‐Ventricular Coupling Strain Index as an Independent Predictor of 10‐Year ASCVD Risk in Diabetic‐Hypertensive Patients

BACKGROUND AND AIMS: The combination of diabetes mellitus and hypertension significantly increases the risk of cardiovascular diseases (CVD). This study aimed to evaluate the association between ventricular-arterial coupling and the 10-year atherosclerotic cardiovascular disease...

Quantitative liver stiffness and steatosis burden in subclinical carotid atherosclerosis: associations and incremental utility assessed by explainable machine learning

Whether quantitative liver steatosis and stiffness provide vascular-risk information beyond conventional cardiometabolic factors remains uncertain. We evaluated their multivariable-adjusted associations and incremental utility for identifying subclinical carotid atherosclerosis....

The comorbidity of hypertension and diabetes modifies the association of body roundness index with chronic kidney disease: findings from two cross-sectional studies in China and the US

This study aimed to investigate the potential effect of the comorbidity of hypertension and diabetes on the association of body roundness index (BRI) with chronic kidney disease (CKD). A total of 20,261 participants from Fuqing Cohort Study (FQCS) in China and 6,434 participants...

High prevalence and immunophenotypic diversity of clonal T‑large granular lymphocytes in JAK2‑mutated myeloproliferative neoplasms

Patients with JAK2‑mutated MPN may develop clonal T‑cell expansions, but the prevalence, immunophenotypic spectrum, and association with other lymphoid clones remain poorly defined. Clonal T‑large granular lymphocyte (T‑LGL) expansions have been observed in myeloproliferative neo...

Astragaloside IV improves MASLD via GCN5-LXRα/SREBP1c signaling pathway-mediated hepatic de novo lipogenesis

BACKGROUND: Astragaloside IV (AS-IV), a bioactive saponin from Astragalus membranaceus, shows promise for treating metabolic dysfunction-associated steatotic liver disease (MASLD), though its mechanisms remain unclear. PURPOSE: This study aimed to elucidate how AS-IV alleviates h...

Targeting the NOTCH1 signaling pathway in chronic lymphocytic leukemia enhances the efficacy of CD19 CAR-T cells

Abstract Background The therapeutic efficacy of chimeric antigen receptor T (CAR-T) cells targeting CD19 in chronic lymphocytic leukemia (CLL) treatment can be limited by target cell antigen loss. This study aims to elucidate how the intrinsic NOTCH1 signaling activity in CLL cel...

Leveraging the Iron-Probe-MurB Interaction: An Enhanced Platform for PET Imaging of Bacterial Infections

Abstract The accurate discrimination of bacterial infections from sterile inflammation is a critical yet unresolved challenge in clinical diagnostics. To address this, we designed and synthesized a series of 68Ga-labeled PET tracers derived from the FDA-approved iron chelator, de...

Association of serum sodium concentration and duration with 28-day mortality in critically ill patients

Abstract Dysnatremia is common in critically ill patients, but the prognostic relevance of its duration remains uncertain. This retrospective cohort study used MIMIC-IV data from 2008 to 2022. Of 94,458 ICU records screened, 9,799 adults with a first ICU stay of at least 7 days w...

Bibliometric analysis of global research activity and emerging trends in radioiodine refractory differentiated thyroid cancer

Radioiodine-refractory differentiated thyroid cancer (RAIR-DTC) remains a critical challenge and focal point in thyroid cancer management, garnering increasing attention and discourse among both the public and scientific community in recent years. To date, however, no comprehensi...

Prognostic association of postoperative pre-radiotherapy neutrophil-to-lymphocyte ratio with disease-free survival in oral squamous cell carcinoma patients undergoing adjuvant volumetric modulated arc therapy: an exploratory analysis

The prognostic value of postoperative pre-radiotherapy neutrophil-to-lymphocyte ratio (NLR) in oral squamous cell carcinoma (OSCC) patients receiving adjuvant volumetric modulated arc therapy (VMAT) remains inadequately characterized. This study evaluated the association of NLR w...

Stress-resolved longitudinal single-cell and spatial transcriptomic analysis supports a tumor–immune remodeling framework during chemoradiotherapy in cervical cancer

Concurrent chemoradiotherapy (CRT) is standard for locally advanced cervical cancer, but early links between tumor adaptation and immune dysfunction remain incompletely resolved. We conducted an exploratory secondary analysis of public longitudinal single-cell RNA-sequencing data...

Sunflower oil-loaded lycopene protects intestinal barrier integrity following traumatic brain injury

Traumatic brain injury (TBI) is a major cause of morbidity, mortality, and long-term neurological impairment. Growing evidence suggests that the gut-brain axis plays a crucial role in TBI pathophysiology, with gut microbiota dysbiosis potentially inducing inflammation and aggrava...

Neurotoxicity of PM2.5-Bound Multi-Pollutant Mixtures in Parkinson’s Disease: Exploring the INPP5D/SHIP1-PI3K-AKT Axis via an Integrative Multi-Omics Study

Accumulating epidemiological evidence links ambient PM2.5 exposure to elevated Parkinson’s disease (PD) risk, yet the neurotoxicity triggered by PM2.5 multi-pollutant mixtures under real co-exposure scenarios remains insufficiently elucidated. This study integrated two-sample Men...

Association of the composite dietary antioxidant index with advanced cardiovascular–kidney–metabolic syndrome in U.S. adults

This study aimed to examine the association between the composite dietary antioxidant index (CDAI) and advanced cardiovascular–kidney–metabolic syndrome (CKM) and characterize its dose–response shape. This cross-sectional study included 23,968 National Health and Nutrition Examin...

Patterns of survival and recurrence in non-pathological complete response to neoadjuvant immunochemotherapy for esophageal squamous cell carcinoma: a real-world single-center study

Neoadjuvant immunochemotherapy (NICT) is a strategy for locally advanced esophageal squamous cell carcinoma (ESCC), yet responses vary. Survival and recurrence patterns in non-pathological complete response (non-pCR) patients remain incompletely defined. This single-center retros...

Treatment disruption and psychological distress among hemophilia patients during the COVID-19 pandemic: the role of healthcare accessibility

The strict zero-COVID policies in China, lasting from early 2020 to late 2022, posed unique challenges to chronic disease management. While the pandemic’s mental health impact is well-documented, evidence regarding patients with hemophilia remains limited. This study aimed to ass...

Trends in incidence, prevalence, and mortality of peptic ulcer disease in Asia (1990–2023) and projections to 2040

Background: This study provides the first comprehensive assessment of the burden of peptic ulcer disease (PUD) in Asia, analyzing epidemiological trends from 1990 to 2023 with projections to 2040. Methods: Using data from the Global Burden of Disease Study 2023, we analyzed PUD m...