Fujian Medical University

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

Perioperative Imatinib Treatment Continuation Patterns and Long-Term Outcomes in Locally Advanced Gastrointestinal Stromal Tumors After Neoadjuvant Therapy: An Exploratory Two-Center Retrospective Study

Perioperative Imatinib Treatment Continuation Patterns and Long-Term Outcomes in Locally Advanced Gastrointestinal Stromal Tumors After Neoadjuvant Therapy: An Exploratory Two-Center Retrospective Study

CT-based three-dimensional virtual reduction with implant templating for tibial plateau fractures involving the posterolateral region: a retrospective cohort study of early postoperative CT reduction quality

Tibial plateau fractures involving the posterolateral region remain technically challenging because of their deep location, limited surgical exposure, and surrounding anatomical constraints. This study investigated whether CT-based three-dimensional virtual reduction with implant...

Validation of [89Zr]Zr-oxine labelling and PET/CT imaging for tracking mesenchymal stem cells in mice and patients with perianal fistula

Allogeneic umbilical cord-derived mesenchymal stem cells (TH-SC01) hold promise for treating perianal fistulas (pf) in Crohn’s disease (pfCD); however, like other live-cell products, their in vivo behaviour remains unclear. Zirconium-89 ([ 89 Zr]Zr)-oxine positron emission tomogr...

Novel CTLA4 Haploinsufficiency with Pure Red Cell Aplasia as the Core Manifestation: Insights from a Sibling Pair with Divergent Tumorigenic Outcomes

Cytotoxic T‑lymphocyte antigen‑4 (CTLA4) is a key immune checkpoint molecule, and its haploinsufficiency can lead to a highly heterogeneous immune dysregulation syndrome; however, its association with pure red cell aplasia (PRCA) remains to be systematically characterized. Here w...

Red blood cell distribution width and 28 days mortality in sepsis-associated delirium: a multicenter study and machine learning analyses

The specific prognostic relevance of red blood cell distribution width (RDW) regarding sepsis-associated delirium (SAD) remains poorly understood. Data were retrieved from the MIMIC-IV and eICU-CRD registries. Kaplan–Meier curves, multivariable Cox regression, restricted cubic sp...

Risk stratification of long-term distant metastasis in nasopharyngeal carcinoma: a retrospective study of 7,045 patients diagnosed from 2012 to 2022

Distant metastasis (DM) remains the leading cause of treatment failure in nasopharyngeal carcinoma (NPC), severely compromising long-term survival. Despite advances in screening and multimodal therapies, a considerable proportion of patients still develop DM after standard treatm...

Latent profiles and predictors of fear of childbirth in late pregnancy: a parity-specific analysis

Fear of childbirth (FoC) is a common psychological concern among women in late pregnancy. Variation in reported prevalence and associated factors across studies reflects methodological heterogeneity and highlights the need for person-centred approaches to identify clinically mean...

Virtual reality-assisted rehabilitation after arthroscopic rotator cuff repair for small-to-medium supraspinatus tears: a prospective assessor-blinded randomized controlled trial

Rehabilitation after arthroscopic rotator cuff repair (ARCR) must protect the repair while restoring active shoulder use. Immersive virtual reality (VR) can standardize rehabilitation tasks and provide immediate feedback, but whether VR delivery offers benefit over conventional d...

Mechanistic Decoupling of the cis - and trans -Cleavage Activities of Cas12a via Phosphorothioate-Induced Kinetic Trapping

Abstract CRISPR-Cas12a is widely utilized for genome engineering and nucleic acid diagnostics, being distinguished by its indiscriminate single-stranded DNA (ssDNA) trans-cleavage activity triggered by its specific cis-target recognition. However, the precise kinetic coordination...

Untargeted Metabolomics Reveals Metabolic Perturbations in Community-Dwelling Elderly Exposed to PM2.5-Bound Ester Compounds

Background/Objectives: Ambient fine particulate matter (PM2.5) poses significant health risks to older adult populations, yet the specific contributions of its chemical constituents, particularly non-phthalate and non-organophosphate ester compounds, remain poorly understood. Thi...

Hepatic GPR110 plays a complex and context-dependent role in metabolic dysfunction-associated steatotic liver disease

Metabolically-dysfunction-associated steatotic liver disease (MASLD)—formerly known as nonalcoholic fatty liver disease (NAFLD) —is now the most common chronic liver disease worldwide, affecting more than 30% of the global population. Recent studies have documented seemingly cont...

Association between perioperative D-dimer dynamics and post-treatment localized intravascular coagulation in venous malformations

OBJECTIVE: To investigate the association between the change in D-dimer levels (ΔD-dimer) and the development of localized intravascular coagulation (LIC) following surgical intervention in patients with venous malformations. METHODS: This retrospective cohort study enrolled 267...

Association between adverse childhood experiences and accelerated aging of middle-aged and older Chinese: based on the China health and retirement longitudinal study

This study used data from the China Health and Retirement Longitudinal Survey (CHARLS) to examine the association between adverse childhood experiences (ACEs) and accelerated aging in middle-aged and older Chinese, with implications for healthy aging interventions. A total of 832...

Research on creep life prediction of entangled metallic wire material based on performance degradation parameters and time–temperature superposition principle

The entangled metallic wire material (EMWM) exhibits the significant advantages, including high damping performance, resistance to aging, and strong environmental adaptability, making it widely applicable across various fields. As application fields of EMWM have been expanded, ex...

MZB1 marks a B-cell-associated stromal-immune microenvironment in cervical squamous cell carcinoma: a multi-omics analysis

BACKGROUND: Cervical squamous cell carcinoma (CSCC) is a common gynecologic malignancy with a heterogeneous tumor immune microenvironment (TIME). The role of MZB1, a B-cell-specific molecular chaperone, in CSCC remains poorly characterized. METHODS: We performed an integrative mu...