Fujian Medical University

Systemic artery-to-pulmonary artery fistulas and recurrence of noncancer-related hemoptysis after bronchial artery embolization: a retrospective study

To investigate the clinical and angiographic characteristics of systemic artery-to-pulmonary artery fistulas (SA-PAFs) in patients with noncancer-related hemoptysis undergoing bronchial artery embolization (BAE), and to assess their associations with procedural outcomes and recur...

Trajectories of memory function before and after cardiovascular disease among hypertensive patients

The trajectories of cognitive function before and after cardiovascular disease (CVD) have been widely explored in the general population, but less is known in hypertensive patients who are regarded as the most vulnerable patients for both CVD and dementia. The cohort study was co...

Automatic segmentation of craniomaxillofacial complex and mandible in dental CBCT images using a TransUNet-based deep learning model

Accurate segmentation of craniomaxillofacial structures from cone beam computed tomography (CBCT) is essential for digital dentistry, but conventional manual and semi-automated methods are time-consuming and operator-dependent. This study aimed to develop and validate a TransUNet...

Integrated postmortem brain transcriptomics identifies a five-gene Alzheimer’s disease-associated signature with a reproducible whole-blood CEBPB correlate

Transcriptomic profiling provides a systems-level view of Alzheimer’s disease (AD), capturing coordinated neuronal, glial, vascular, and immune-related changes. Yet the same breadth that makes transcriptomics informative also complicates interpretation because technical heterogen...

Synergistic prognostic value of tumor-infiltrating lymphocytes and microvessel density in breast cancer

Breast cancer is a heterogeneous disease forming an intricate ecosystem, and its prognosis is affected by multiple factors, with the complexity of the tumor microenvironment (TME) being a pivotal determinant. Tumor-infiltrating lymphocytes (TILs) and microvessels, as key componen...

Predictive value of decreased pulse wave amplitude decrease for cardiovascular risk stratification in obstructive sleep apnea

Obstructive sleep apnea elevates cardiovascular risk, but existing biomarkers fail to capture sleep-specific hemodynamic changes. This study evaluates the pulse wave amplitude decrease index, a photoplethysmography-derived measure of vascular/autonomic reactivity during respirato...

Development and validation of a diagnostic model for prevalent liver-related events in patients with non-alcoholic fatty liver disease

The burden of liver-related events (LREs) among hospitalized patients with non-alcoholic fatty liver disease (NAFLD) is substantial. We developed a diagnostic model based on routine clinical parameters to estimate the probability of prevalent LREs status ascertained during the in...

UFMylation of SHBs increases protein stability by antagonizing ubiquitination and promotes virion production

ABSTRACT Post-translational modifications orchestrate virus–host interactions, yet their roles in the hepatitis B virus (HBV) life cycle remain incompletely defined. The small hepatitis B surface antigen (SHBs)—the most abundant HBV protein—drives immune evasion, pathogenesis, an...

Clinical analysis of Chlamydia psittaci pneumonia combined with pleural effusion

Abstract Purpose The aim of this study is to elucidate the clinical manifestations, computed tomography (CT) imaging characteristics, and therapeutic outcomes of Chlamydia psittaci pneumonia in the presence of pleural effusion, thereby enhancing the clinical acumen of practitione...

Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence

The absence of accurate, noninvasive, scalable screening tools keeps early esophageal cancer (EC) detection a global health challenge. Although noncontrast computed tomography (NC CT) is widely accessible, the esophagus is a hollow tubular structure prone to collapse and motion a...

Effect of electroacupuncture on postoperative delirium in older patients undergoing major surgery: a prospective, multicenter, randomized sham-controlled trial

Abstract Purpose Postoperative delirium (POD) is a common complication in older patients undergoing major surgery and is associated with prolonged hospitalization, delayed recovery, and increased mortality. This study evaluated whether perioperative electroacupuncture (EA) reduce...

Cataract GWAS meta-analysis and multi-omics Mendelian randomisation inform disease mechanisms and candidate target prioritisation

Background Cataract is a highly prevalent cause of visual impairment and blindness worldwide. Although genome-wide association studies (GWAS) have mapped multiple cataract risk loci, further work is required towards translating these signals and integrating multi-omics evidence f...

Early renal replacement therapy and short-term mortality in higher-risk KDIGO stage 2 sepsis-associated acute kidney injury with sustained oliguria: a target trial emulation

Abstract Whether proactive early renal replacement therapy (RRT) improves outcomes in higher-risk patients with KDIGO stage 2 sepsis-associated acute kidney injury (SA-AKI) and sustained oliguria remains uncertain. We evaluated its association with short-term mortality. We emulat...

Trichinella spiralis galectin disrupts gut epithelial integrity and mediates larval invasion via acting MUC13- ROCK2/MAPK pathway

Background Gut epithelium serves as a critical barrier against Trichinella spiralis larval invasion, Parasite-derived galectins are involved in host–parasite interactions, including invasion and immune modulation. This study investigated the role of T. spiralis galectin (Tsgal) i...

An ENE-related transcriptomic signature predicts distant metastasis risk and immune microenvironment features in nasopharyngeal carcinoma

Extracapsular nodal extension (ENE) is an adverse prognostic factor in nasopharyngeal carcinoma (NPC). In this study, we analyzed RNA-seq data from 159 NPC patients stratified by ENE status, identified differentially expressed genes, and developed an eight-gene machine-learning s...

A proteome-derived inflammatory epithelial-myeloid state is associated with adverse outcome in intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (ICC) is molecularly heterogeneous, and the cellular basis of adverse bulk-omics states is often unclear. We examined whether a proteome-derived prognostic score reflects an inflammatory malignant epithelial-myeloid state. A score derived from Fuda...

Prognostic value of preprocedural right ventricular free-wall longitudinal strain for one-year mortality after transcatheter aortic valve implantation

TAVI has improved outcomes in severe AS, yet residual mortality risk remains. Current risk models primarily rely on left ventricular parameters, with limited incorporation of right ventricular function. To evaluate the prognostic value of preprocedural RV-FWLS for 1-year mortalit...

Multi-omics profiling reveals PIK3CA -driven immunometabolic reprogramming in cervical cancer

The PIK3CA mutation is a prevalent driver in cervical cancer, but its role in orchestrating a coordinated remodeling of transcriptional, translational, and metabolic networks is poorly understood. We introduced the PIK3CA-E545K mutation into cervical cancer U14 cells via CRISPR/C...

Psychiatric disorders and gynecologic tumors

Previous epidemiological evidence has suggested associations between psychiatric disorders and gynecologic tumors, but the causal relationships have not been fully characterized. This study aims to investigate the potential causal relationships using genetic instrumental variable...

The cGAS-STING pathway in acute myocardial infarction: Biomarker discovery and mechanistic insights

Acute Myocardial infarction (AMI) continues to be a severe deadly disease with a high case-fatality rate and great psychological and economic costs. Despite the development of new therapies, early diagnosis and treatment optimization still are problematical. Here we applied the i...