Fujian Medical University

Psychiatric disorders and gynecologic tumors

Previous epidemiological evidence has suggested associations between psychiatric disorders and gynecologic tumors, but the causal relationships have not been fully characterized. This study aims to investigate the potential causal relationships using genetic instrumental variable...

Development and validation of a nomogram for predicting 28-day mortality in critically ill liver cirrhotic patients with coagulopathy

Although scoring systems exist to predict outcomes in patients with cirrhosis, specific systems for critically ill cirrhotic patients with coagulopathy are lacking. The aim of the study was to establish a reliable predictive model for 28-day mortality in cirrhotic patients with c...

Integrated expression and network-based characterization of H19-associated molecular alterations in Metabolic Dysfunction-Associated Fatty Liver Disease

Metabolic dysfunction-associated fatty liver disease (MAFLD) is characterized by hepatic lipid accumulation and metabolic dysregulation. However, reproducible noncoding RNA-associated molecular alterations in human liver tissue remain incompletely defined. We aimed to characteriz...

The cGAS-STING pathway in acute myocardial infarction: Biomarker discovery and mechanistic insights

Acute Myocardial infarction (AMI) continues to be a severe deadly disease with a high case-fatality rate and great psychological and economic costs. Despite the development of new therapies, early diagnosis and treatment optimization still are problematical. Here we applied the i...

A comparative study on the clinical efficacy and complications of proximal femoral nail antirotation and femoral neck system in the treatment of basicervical femoral neck fracture (AO/OTA 31-B3)

Basicervical femoral neck fractures (FNFs) are prone to internal fixation failure owing to their inherent biomechanical instability. This study compares the efficacy of femoral neck system (FNS) and proximal femoral nail anti-rotation (PFNA) in treating basicervical FNF. A retros...

Shared oral microbiome signatures linking periodontitis and autoimmune thyroiditis: NHANES 2009–2012

Objective To examine the association between periodontitis severity and autoimmune thyroiditis (AIT) in a nationally representative US sample and to explore oral microbiome features shared between the two conditions.Methods We analyzed adults from NHANES 2009–2012 with complete p...

A retrospective study of correlation between insulin resistance surrogate indexes, inflammatory markers, and peripheral arterial disease in type 2 diabetes mellitus

Background This study aimed to investigate the correlation between six surrogate indexes of insulin resistance (IR) and six inflammatory markers with diabetic peripheral arterial disease (DPAD) in patients with type 2 diabetes mellitus (T2DM). Methods Clinical and hematological d...

Green Light‐Driven, Diastereoselective Synthesis of Pentasubstituted α ‐Trifluoromethylated Pyrrolidines via a Singlet Carbene Process

Comprehensive Summary Trifluoromethylated heterocycles represent privileged structural motifs in pharmaceuticals and agrochemicals, as the incorporation of a CF 3 group significantly enhances metabolic stability, lipophilicity, and bioactivity. Among these, α ‐trifluoromethyl pyr...

Texture similarity network uncover schizophrenia subtypes with unique molecular signatures

Abstract Schizophrenia manifests complex heterogeneity across multiple dimensions, posing major challenges for precise diagnosis and treatment. Developing objective biomarkers to stratify patients into stable subtypes is essential for heterogeneity resolving and precision medicin...

Stimuli-responsive magnetic black phosphorus-based nanoreactor for chirality-dependent anoikis induction in cancer therapy

Anoikis presents an alternative scheme for suppressing tumor metastasis. While limited by off-target effects, rapid degradation, and reactive oxygen species (ROS) accumulation, anoikis resistance remains a persistent challenge for current tumor therapy. The use of external and en...

ETV4 promotes lipid accumulation and oxidative stress in metabolic dysfunction-associated fatty liver disease by transcriptionally activating TYMS

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a chronic liver disorder, with non-alcoholic steatohepatitis (NASH) as its progressive stage. This study aimed to identify diagnostic biomarkers and investigate the mechanism by which ETS variant transcription factor...

m⁶A-dependent TRIM71 stabilization by YTHDC1 promotes hepatoblastoma progression

Abstract Hepatoblastoma (HB) is the most common primary malignant liver cancer in children. Although complete surgical resection and standardized chemotherapy remain the most effective treatments for HB, they are not curative for all patients. Therefore, a deeper understanding of...

Repurposing diuretics for bipolar disorder: a Mendelian randomization study

Despite increasing therapeutic options to treat bipolar disorder (BD), many patients fail to reach treatment targets. The study sought to explore the potential of diuretics in preventing and treating BD through Mendelian randomization (MR). We utilized a two-sample MR design to a...

Prenatal and Postnatal Identification of Phelan–McDermid Syndrome in a Tertiary Referral Center: A 15-Case Series and Literature Review

Objectives: To characterize the clinical and genetic features of Phelan–McDermid syndrome (PMS) in a Chinese prenatal and postnatal cohort, explore genotype–phenotype correlations, and provide evidence to support prenatal genetic counseling. Methods: G-banded karyotyping, single-...

Bisphenol A and Its Substitutes Bisphenol S/Bisphenol F in Combined Exposure Collectively Exacerbate Hepatotoxicity by Triggering Oxidative Stress and Inflammatory Responses via the PI3K-Akt/NF-κB Axis

Abstract Bisphenol A (BPA) and its substitutes bisphenol S (BPS) and bisphenol F (BPF) are environmental endocrine-disrupting chemicals that frequently co-occur. However, the hepatotoxic effects and underlying mechanisms of their combined exposure remain unclear. This study integ...

Light during the rest phase disrupts hippocampal clock function and impairs object recognition memory

Light exposure in the circadian rest phase is common during shift work and late-night activity, but its effects on memory remain unclear. Using male C57BL/6J mice, we show 6-day rest-phase light exposure (RPL), which combines mistimed light exposure with enforced wakefulness, imp...

Puerarin Attenuates Binge Ethanol-Induced Cortical Neurotoxicity in Association with AKT/mTOR Signaling and Autophagy-Related Responses

, has demonstrated neuroprotective potential in multiple neurological disorders; however, its effects on ethanol (EtOH)-induced cortical injury and the associated molecular responses remain incompletely understood. In the present study, network pharmacology was combined with in v...

APOC1 deficiency disrupts M1/M2 macrophage balance via the ferroptosis and suppresses trophoblast invasion in recurrent pregnancy loss

The maternal–fetal interface requires tightly regulated immune homeostasis for successful pregnancy. Dysregulation of macrophage polarization and trophoblast invasion is implicated in recurrent pregnancy loss (RPL). However, the molecular mechanisms by which macrophage dysfunctio...

Lactylation of OVOL2 impairs its tumor-suppressive activity to promote hepatocellular carcinoma growth

Lactylation, a metabolism-associated post-translational modification derived from lactate accumulation, has emerged as an important regulator linking metabolic reprogramming to cancer progression. Increasing evidence suggests that lactylation participates in tumor development thr...

Prognostic impact of supraclavicular lymph node metastasis in thoracic oesophageal squamous cell carcinoma in a large retrospective study

The definitions of regional nodes differ between the 12th edition of the JES and the UICC staging systems, and the most prominent difference is in the status of the supraclavicular lymph nodes (SCLN). This study was designed to investigate the prognostic impact of metastasis to S...