Fujian Medical University

MRI-Based Radiomics Model for Pretreatment Prediction of Pathological Lymph Node Metastasis in Neuroendocrine Carcinoma of the Cervix: Dual-Center Development and External Validation

Objectives: To develop and externally validate MRI-based radiomics and clinicoradiomics models for predicting pathological lymph node metastasis (LNM) in neuroendocrine carcinoma of the cervix (NECC). Methods: This retrospective two-center study included 133 patients who underwen...

Beyond Co-Localization: DeepCoEx Learns Exclusion-Aware Spatial Representations in Mass Spectrometry Imaging via Dual-Contrastive Learning

Abstract Mass spectrometry imaging (MSI) provides spatially resolved molecular profiles, yet the existing computational workflows are heavily biased toward co-localization and remain limited in characterizing exclusion-like spatial relationships, especially when reliable negative...

Association Between Sperm DNA Fragmentation Index and Outcomes of Fresh Embryo Transfer in IVF/ICSI Cycles: A Retrospective Cohort Study

OBJECTIVE: This study explored the impact of the sperm DNA fragmentation index (DFI) on clinical outcomes and infant safety in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) among infertile couples. METHODS: A retrospective cohort study analyzed clinical data...

Selective Cancer Cell Killing via a Fluorofoldamer‐Based Proton Channel That Triggers Ferroptosis

ABSTRACT We report a new class of aromatic foldamer‐based artificial proton channels incorporating fluorinated building blocks, which exhibit high proton transport efficiency and selectivity. The lead channel, 2 , shows outstanding proton transport activity (EC 50 = 13.1–14.7 nM)...

Effects of dietary quality on type 2 diabetes risk and the mediating role of inflammatory markers

Abstract This study aimed to explore the association between multiple dietary quality indices and diabetes risk and investigate the potential role of systemic inflammatory markers in such relationships. Data were obtained from 21 476 participants in the Fuqing Cohort Study who co...

Haematological changes after tonsillectomy in mild thalassemia children recommendations

Objective This study aims to evaluate the alterations in peripheral blood parameters and the therapeutic outcomes following tonsillectomy in pediatric patients diagnosed with mild thalassemia. Methods We conducted a prospective cohort study involving 65 children who underwent ton...

NR3C2 suppresses triple-negative breast cancer progression by regulating mitochondrial ROS homeostasis via NDUFB3

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high molecular heterogeneity and a lack of effective targeted therapies. Increasing evidence indicates that metabolic reprogramming and redox homeostasis are critical determinants of T...

The VCX/VCY gene family member VCX3A encodes an RNA-binding protein that modulates the proliferation and motility of spermatogonia GC-1 cells via pre-mRNA splicing

VCX3A , a member of the VCX / VCY gene family, is predominantly expressed in spermatogonia of the male testis. Emerging evidence implicates that mutations or duplication of VCX3A may contribute to nonobstructive azoospermia. Although VCX3A has been characterized as a nuclear RNA-...

C‐reactive protein–triglyceride glucose index and all‐cause mortality in postmenopausal women: A dual‐cohort study from the National Health and Nutrition Examination Survey and the China Health and Retirement Longitudinal Study

BACKGROUND: Insulin resistance and chronic inflammation each predict cardiovascular mortality, but they are usually studied separately. The C-reactive protein-triglyceride glucose index (CTI) combines both, yet its prognostic value in postmenopausal women, who experience concurre...

Nebulized lidocaine for preventing postoperative pulmonary complications in major abdominal surgery

Despite the lung-protective ventilation strategy, high incidence of postoperative pulmonary complications (PPCs) after major non-cardiac surgery remains a major concern in the perioperative care due to high morbidity and mortality. The study aimed to evaluate the efficacy and saf...

Evaluation and validation of a reproducible mNGS workflow for gut Microbiome analysis

Technical variability in pre-analytical and analytical steps significantly hinders the reproducibility of gut metagenomic next-generation sequencing (mNGS). To address this, we developed and evaluated a practical workflow for mNGS. By evaluating three commercial preservation buff...

γ‐Radionuclide Technetium‐99M Activated Long‐Lasting Chemodynamic Therapy and Immunogenic Brachytherapy for Enhanced Antitumor Immunity

ABSTRACT Chemodynamic therapy (CDT) and brachytherapy face critical challenges, particularly the limited efficiency of Fenton reaction and the insufficient antitumor immunogenicity of brachytherapy. In this study, we employ the metal–organic framework nanocomposite Hf‐TCPP@Fe‐ 99...

Biomimetic cell membrane–functionalized lanthanide nanoplatforms: From bio-interface design to precision theranostic applications

Cell membrane coating technology is a biomimetic approach for replicating the intrinsic properties of natural cell membranes that may be useful in nanoscale biomedicine. When applied to lanthanide nanoparticles (LnNPs), cell membrane coatings have the biological functionalities o...

Multiple classification of childhood and juvenile autism spectrum disorder from ABIDE-II sMRI using BN-GO-CNN

Abstract Objectives Autism spectrum disorder (ASD) shows heterogeneous neurodevelopmental patterns across childhood, juvenile development, and adulthood, so binary MRI classification may not fully capture age-and sex-related variation. This study proposes a proof-of-concept frame...

Norepinephrine-driven neutrophilic inflammation accelerates ulcerative colitis progression

Objectives The role of the sympathetic neurotransmitter norepinephrine (NE) in ulcerative colitis (UC) remains controversial. We aimed to elucidate NE's precise mechanisms in UC, focusing on colonic metabolism, diagnostic potential, and local immune interactions. Methods Colonic...

Vasoepididymostomy‐First Versus Primary ICSI for Epididymal Obstructive Azoospermia: Real‐World Reproductive Outcomes for Treatment Selection

ABSTRACT Background In couples with epididymal obstructive azoospermia (EOA), choosing between microsurgical vasoepididymostomy (MVE)‐first and primary intracytoplasmic sperm injection (ICSI) remains a practical treatment‐selection challenge. Conventional endpoints such as patenc...

Intraoperative tachycardia burden, diastolic hypotension, and in-hospital mortality after noncardiac surgery: a retrospective cohort study

Intraoperative hypotension is an established perioperative risk marker, but the relevance of intraoperative tachycardia remains uncertain. We examined tachycardia, diastolic blood pressure (DBP), mean arterial pressure (MAP), and temporal co-occurrence in noncardiac surgery. We c...

Quality optimization with low positive factual hallucination for the HPI in hyperthyroidism admission notes using multi agent LLM with RAG

Admission note quality affects clinical safety and research reliability, yet resident drafts often suffer from missing information, unclear logic, and other issues, requiring time-consuming manual review. Current large language models (LLMs) focus on text generation or formatting...

Integrated multi-omic analysis characterizes an IFNγ-responsive-to-myeloid-suppressive immune continuum in immune-active hepatocellular carcinoma

Immune-active hepatocellular carcinoma (HCC) is commonly treated as a single inflamed phenotype, although its internal immune heterogeneity remains incompletely defined. We integrated public bulk transcriptomic, single-cell, spatial transcriptomic, proteomic, phosphoproteomic, an...

Three-year outcomes of combined surgical peripheral iridectomy, goniosynechialysis and goniotomy for advanced primary angle-closure glaucoma: a multicentre study

Aims To assess the 3-year efficacy and safety of combined surgical peripheral iridectomy (SPI), goniosynechialysis (GSL) and goniotomy (GT) for advanced primary angle-closure glaucoma (PACG) without cataract. Methods This was a multicentre prospective observational study with ext...