Fujian Medical University

The abscopal effect and systemic immune reprogramming: from phenomenon to therapeutic design

The classical abscopal effect is defined here as objective regression of a verified non-irradiated tumor lesion following local radiotherapy. An immune abscopal phenomenon denotes a prespecified, reproducible immune change within such a lesion that is attributable to the local in...

Intraluminal thrombus distribution pattern is associated with abdominal aortic aneurysm rupture at presentation: a single-centre retrospective study

Intraluminal thrombus (ILT) is present in the majority of abdominal aortic aneurysms (AAA), yet its role in rupture remains incompletely defined. This study examined whether the circumferential distribution pattern of ILT—classified as circumferential, eccentric, or absent/minima...

Implicit Health Beliefs and Suicidal Ideation in Chinese College Students: The Serial Mediating Roles of Lifestyle Behaviors and Anxiety Symptoms

The growing prevalence of mental health problems and suicidality among university students highlights the need to identify potentially modifiable psychological pathways that can inform preventive interventions. This study investigated the association between implicit health belie...

Gut Microbiota and Aldosterone Regulate Natriuretic Peptide B Expression to Drive Mitophagy and Metabolic Reprogramming in Sepsis‐Like Model of Myocardial Injury

BACKGROUND: Myocardial injury is a major contributor to mortality in sepsis, yet the mechanisms underlying gut-heart communication in sepsis-induced myocardial injury remain insufficiently defined. Natriuretic peptide B (NPPB) is a cardiac stress-responsive gene, but its involvem...

Predicted STAT1-BRAF and IRF7-MET Regulatory Links Are Associated with MAPK Pathway Reactivation and Targeted Therapy Resistance in Melanoma

Resistance to BRAF inhibitors (BRAFi), alone or with MEK inhibitors (MEKi), limits durable responses in BRAF-mutant melanoma. To characterize resistance-associated cell-state evolution, we analyzed 674 melanoma cells from six mice bearing tumors from a single patient-derived BRAF...

Hemodynamic prediction of postoperative recurrence in trigeminal neuralgia associated with vertebrobasilar dolichoectasia: development of a nomogram model

Trigeminal neuralgia caused by vertebrobasilar dolichoectasia (VBD-TN) demonstrates a higher postoperative recurrence rate following microvascular decompression (MVD) than typical vascular compression. This study aimed to develop a clinical prediction model incorporating hemodyna...

Predicting radiation esophagitis after lung cancer radiotherapy using dose-volume, radiomic and dosiomic features: an external validation study

Acute radiation esophagitis can interrupt thoracic radiotherapy, but it remains unclear whether image- and dose-derived features improve prediction beyond dose-volume histogram (DVH) metrics and retain their performance across institutions. We externally validated seven models ba...

Selection and prediction of targeted serum protein biomarkers for early diagnosis of esophageal squamous cell carcinoma

Achieving early diagnosis of esophageal squamous cell carcinoma (ESCC) is crucial for reducing the disease burden. This study aims to identify potential serum protein biomarkers associated with the early diagnosis of ESCC in two independent populations and further develop diagnos...

Transient arousal-driven or valence-driven? The effects of alerting cues on the attentional boost effect in depression-prone individuals

Abstract Background Depression-related negative emotional bias is widely regarded as a core cognitive mechanism underlying the maintenance of depressive states. However, it remains unclear whether such biases disrupt fundamental cognitive enhancement processes driven by transient...

A PRK-armed oncolytic adenovirus drives calreticulin exposure for dendritic cell licensing to prime antitumor CD8⁺ T cells and synergizes with anti-PD-1 or CAR-T therapy in colorectal cancer

Abstract Background The therapeutic potential of oncolytic adenoviruses (ADVs) in colorectal cancer is constrained by a counterproductive host response: virus-triggered hyperactivation of the pro-survival AKT pathway, which fosters an immunosuppressive tumor microenvironment. Met...

Quantitative image feature integrated digital pathology model based on deep learning and machine learning for binary histological severity stratification of ulcerative colitis

The STRIDE II consensus recognizes histopathological healing in ulcerative colitis as a key therapeutic target. This study aimed to develop and internally evaluate a quantitative image-based model for the binary classification of mild versus moderate-to-severe UC based on histopa...

Chinese translation, cultural adaptation, and psychometric testing of the patient education materials assessment tool for audiovisual materials

Abstract The provision of health information that can be easily understood by the general public can help improve health behaviors. However, there is a lack of tools to assess the quality of health education videos in the Chinese context. These tools are essential for the popular...

Climate classification, sociodemographic development, and the burden of inflammatory bowel disease in tropical countries

Geographic definitions of the tropics may obscure substantial climatic heterogeneity. Climate classification provides a more ecologically meaningful framework for evaluating inflammatory bowel disease (IBD) in tropical settings. However, few studies have examined tropical IBD bur...

A CCCTC-binding factor (CTCF)-fatty acid desaturase 1 (FADS1) axis regulates oncogenic energy metabolism in hepatocellular carcinoma

CCCTC-binding factor (CTCF) is a highly conserved DNA-binding protein crucial for 3D genome organization and gene regulation. Previous studies have shown that CTCF overexpression in hepatocellular carcinoma (HCC) is associated with poor prognosis. This study aimed to elucidate th...

Efficacy and Safety of the First Adalimumab Biosimilar in Chinese Children with Severe Plaque Psoriasis: The PISCES Study, a Multicenter Prospective Study

Adalimumab, a monoclonal antibody targeting tumor necrosis factor-alpha, has been approved for the treatment of severe plaque psoriasis in children aged 4 years and older. Data on its use in the clinical management of pediatric psoriasis in China remains limited. This study is th...

Development and validation of a predictive nomogram for cesarean delivery in term singleton pregnancies complicated by small for gestational age undergoing labor induction

Abstract Objective: This study aimed to identify antenatal and intrapartum risk factors associated with cesarean delivery in term singleton pregnancies complicated by small for gestational age (SGA) and to develop a predictive model. Methods:We conducted a retrospective case-cont...

In vivo and FACS-based CRISPR/Cas9 screening uncovers VENTX as a crucial element in maintaining seminoma stemness

Seminoma, which is the most frequent testicular germ cell tumor, has stem cell-like features related to treatment resistance and recurrence, yet the molecular mechanisms that preserve its stemness are not well understood. This study aimed to discover the tumorigenesis and stemnes...

Histamine and H1R regulate microglia in an IDPN-Induced Mouse Model of Tic-like behaviors

Tic disorder (TD) is a developmental neurological condition characterized by pathological motor and/or vocal tics. Accumulating evidence suggests that central histamine (HA) participates in the onset and development of TD. Recent research highlights HA’s role in neuroinflammation...

Preoperative vascular status, left colic artery management, and clinically relevant anastomotic leakage after anterior resection for rectal cancer: a retrospective cohort study

Clinically relevant anastomotic leakage after rectal cancer surgery is multifactorial, and baseline vascular status may contribute to anastomotic perfusion risk. This study evaluated the associations of patient-level vascular comorbidity, preoperative CT/CTA-derived vascular stat...

Exploring generalizability and explainability of LLMs in classifying clinically rated suicidal ideation using heterogeneous data

Abstract While artificial intelligence (AI) and large language models (LLMs) have shown promise in identifying and classifying suicidal ideation, their generalizability and equity in the presence of heterogeneous clinical data remain largely unexplored. This study hypothesized a...