Cornell University

The cGAS/STING pathway in cancer: translating innate DNA sensing into therapeutic potential

The cGAS/STING pathway is a central innate immune DNA-sensing system that links aberrant DNA species to innate immune and stress-response transcriptional programs and has emerged as a key regulator of tumor-immune interactions. In cancer, pathway outputs are shaped by interconnec...

Comparisons of Novel Risk Stratification Models to the Current cT1a/b Staging in Incidental Prostate Cancer

OBJECTIVE: Incidental prostate cancer (PCa) patients are currently stratified to either cT1a vs. cT1b stage, depending on tumor volume (< 5% vs. > 5%) in the resected tissue. We tested for other models that could improve cancer-specific survival (CSS) predictions. METHODS: Incide...

Computational analysis of a high-density electrode to scale the electric field geometry and intensity for neurostimulation

High-density grid electrodes can be configured to spatially scale the neurostimulation fields and enable the control of depth, intensity, and stimulation vectoring. In this study, we computationally analyze a high-density cluster electrode (HDCE) technology to measure its scalabi...

Multi-scale evapotranspiration and evaporative stress as indicators of vegetation health and drought response – an application in central Missouri, USA

Satellite estimates of evapotranspiration (ET) based on thermal infrared retrievals of land-surface temperature enable monitoring of vegetation water use and health/stress at sub-field to global scales. The information content of these products varies with pixel size, reflecting...

Spatially defined IGF1R-STMN1 axis delineates a metastatic cell state in osteosarcoma

Abstract Metastatic osteosarcoma (OS) remains the leading cause of disease-related mortality, yet effective therapies are still lacking. Here, we integrated single-cell RNA sequencing, spatial transcriptomics, and functional assays to investigate signaling dependencies in OS meta...

Four years on: following the pathway to real world impact of engineering research

Here we present five short case studies in which key authors of papers originally published in Communications Engineering in 2022 describe the impact of their work four years on. These reflections provide a glimpse of what the papers meant for the key researchers involved, their...