Chinese University of Hong Kong

One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections

ABSTRACT Catheter‐related bloodstream infection (CRBSI) is an important clinical problem that causes significant mortality and excess economic cost. Recent epidemiological trends indicate a shift in CRBSI pathogens from Gram‐positive to Gram‐negative bacilli, among which Pseudomo...

Impacts of droughts on biomass burning emissions, air quality, and public health in the Amazon

Abstract. Wildfires in the Amazon, increasingly influenced by climate variability and anthropogenic activities, pose severe environmental and health challenges. While drought events amplify fire activity and emissions, the cascading effects of droughts and deforestation on air qu...

Neuropeptide diversity and evolutionary patterns in crustaceans: insights into adaptations, agonism, and functional importance in organs

<title>Abstract</title> Background Crustaceans exhibit great diversity in anatomical, physiological, and behavioral adaptations, all of which contribute to their evolutionary success, and neuropeptides are important regulators mediating these adaptations. While expansion of certa...

Chitosan Microspheres Incorporating Doxorubicin-Loaded Mesoporous Silica Nanoparticles as a Potential Multifunctional Platform for Postoperative Osteosarcoma Management

Abstract Osteosarcoma remains a major clinical challenge owing to its high recurrence rate, metastatic potential, and the frequent need for postoperative bone reconstruction. Here, we report a multifunctional platform consisting of doxorubicin-loaded mesoporous silica nanoparticl...

Single-leg squat knee biomechanics at 4 months post-operation predicts 6- and 12-month outcomes after anterior cruciate ligament reconstruction: a cohort study

Persistent functional deficits frequently complicate recovery following anterior cruciate ligament reconstruction (ACLR). This prospective cohort study investigated whether sagittal-plane knee biomechanics during a single-leg squat at 4 months post-ACLR predict functional outcome...

Insights into the relationship between menopausal timing and risk of cardiovascular disease: a systematic review and meta-analysis of Mendelian randomization analyses

Cardiovascular disease (CVD) is the leading cause of death and imposes a substantial burden on women’s health. Early onset of menopause, as a unique trait of reproductive aging, has been associated with a higher risk of adverse cardiovascular events in traditional observational s...

The Star Formation History and Evolution of the Ultra-Diffuse M81 Satellite F8D1

Abstract We present deep Hubble Space Telescope (HST) imaging of one of the nearest ultra-diffuse galaxies (UDGs) outside of the Local Group: F8D1, a satellite of M81 known to be tidally disrupting. UDGs are an enigmatic and diverse population, with evolutionary pathways ranging...

Programmable RNA targeting with clustered regularly interspaced short palindromic repeats (CRISPR) effector Cas7-11 in zebrafish embryos and mammalian cells

<title>Abstract</title> <bold>Background</bold> The CRISPR/Cas7-11 system is a recently characterized RNA editing tool that exhibits low toxicity, minimal off-target effects, and reduced collateral RNA cleavage compared with existing methods. Although zebrafish and human embryoni...

Competition mechanisms of interfacial crack propagations in thermal barrier coatings

Abstract Cracking failure of thermal barrier coatings (TBCs) in advanced gas turbines under bending loads presents a persistent engineering challenge, particularly regarding how cracks compete and propagate through multilayer structures. This study addresses that challenge by con...

An explainable biomedical foundation model via large-scale concept-enhanced vision–language pretraining

Artificial intelligence for medical imaging is required to be accurate and interpretable to clinicians. However, current multimodal biomedical foundation models often prioritize performance over explainability. Here we present ConceptCLIP, an explainable biomedical foundation mod...

Induced Pluripotent Stem Cell-Based Platforms for Cardiac-Related Pain Research: Molecular Mechanisms, Experimental Models, and Therapeutic Applications

Cardiac-related pain, including angina pectoris and pain accompanying myocardial infarction, remains clinically important, and existing treatments are inadequate for some patients. Animal and primary-tissue studies provide important mechanistic evidence, but species differences a...

Engineering Hidden Ferroelectric‐Like Distortion for Ultralow Thermal Conductivity in Polar van der Waals Tetradymite

ABSTRACT Ferroelectric‐like polar structures enable diverse functionalities through coupling with charge and phonon transport. Although effective in modulating thermal conductivity, the rational design of novel polar materials with intrinsically low thermal conductivity via ferro...

Tribenzotriquinacene Fused Dimers (“Fusodimers”)—Synthesis and Host–Guest Properties

ABSTRACT The synthesis and structural properties of two stereoisomeric tribenzotriquinacene (TBTQ) derivatives, syn ‐ 4 and anti ‐ 4 , in which two rigid TBTQ bowls share a common benzene ring, are described. Owing to the orthogonal orientation of the three indane wings in each o...

RKHS-Based Latent Position Random Graph Correlation

We study the problem of evaluating the correlation between two latent position random graphs, which is a challenging issue because the latent positions are generally unobservable in random graphs. We introduce a correlation coefficient that is defined in the reproducing kernel Hi...

siRNA-mediated mismatch repair disruption synergizes with oxaliplatin to restore immune surveillance in microsatellite-stable colorectal cancer

Proficient mismatch repair/microsatellite-stable colorectal cancer (pMMR/MSS CRC), which represents the majority of clinical cases, exhibits low tumor mutational burden and minimal responsiveness to immune checkpoint blockade. Disrupting the MMR system has been shown to resensiti...

Effectiveness of 222 nm far-UVC disinfection of airborne and surface bioaerosols in railway trains

Abstract Since urban residents heavily rely on rail transit on a daily basis, controlling airborne infectious disease transmission in railway trains is critical for public health. In recent years, 222 nm far-ultraviolet C (UVC) lamps have emerged as a promising solution for disin...

Embedding e-learning in postgraduate medical education: system-level barriers and enablers in Hong Kong

INTRODUCTION: E-learning is increasingly central to postgraduate medical education (PGME), yet system-level barriers may hinder its integration. In Hong Kong, the Academy of Medicine (HKAM) has invested in a learning management system and faculty development, but uptake among Aca...

Enhanced Antibiotics Sieving by Exfoliated TiS2 Membranes via Surface Functionalization and Passivation

Abstract Transition metal dichalcogenide (TMD) nanolaminate membranes hold great promise for molecular sieving due to their two-dimensional capillary structures, which facilitate size-restricted diffusion. However, many transition metal sulfides exhibit intrinsic instability and...

State entrepreneurialism under economic transition: Bounded rationality in China’s high-speed rail new town governance

Drawing on 16 high-speed rail (HSR) new towns along the Beijing–Shanghai corridor, this paper develops a middle-range explanation of how state entrepreneurialism is practiced and differentiated under conditions of economic transition in China. While the notion of state entreprene...

ARport: an augmented reality system for markerless image-guided port placement in robotic surgery

Abstract Purpose Precise port placement is a critical step in robot-assisted surgery, where port configuration influences both visual access to the operative field and instrument maneuverability. To bridge the gap between preoperative planning and intraoperative execution, we pre...