Chinese University of Hong Kong

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

ABSTRACT Planar cell polarity (PCP) signaling is an evolutionarily conserved mechanism regulating polarized cellular and tissue behaviors in diverse morphogenetic and physiological processes. Disruption or aberrant activation of PCP signaling can cause developmental defects or pr...

Exploring meaningful work as a buffer for psychological well-being for women entrepreneurs: does caregiving responsibility matter?

Purpose Drawing on the job demands-resources (JD-R) model, this study explores how meaningful work mitigates caregiving responsibility and psychological well-being among women entrepreneurs. Design/methodology/approach A cross-sectional survey was conducted among 360 women engage...

Associations of remnant cholesterol and apolipoprotein B with kidney function decline and progression to kidney failure in hospitalized patients with type 2 diabetic kidney disease: a retrospective cohort study

Diabetic kidney disease (DKD) is one of the leading causes of kidney failure (KF). Emerging lipid markers such as remnant cholesterol (RC) and apolipoprotein B (ApoB) have been associated with kidney disease progression. However, no study has comprehensively evaluated the associa...

Barriers and facilitators to physical activity promotion by healthcare professionals: an umbrella review

Abstract Background Physical inactivity is consistently associated with the incidence of chronic diseases. The clinical environment may be an ideal setting to promote physical activity (PA). To date, substantial efforts have been made by multiple institutions to encourage PA prom...

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other embryonal tumors

WHO CNS5 mandates integrated histo-molecular classification of medulloblastomas (MBs) and other CNS embryonal tumors. However, advanced molecular diagnostics remain inaccessible in many low- and lower-middle-income countries (LICs/LMICs), limiting implementation of molecularly in...

Asian Neurogastroenterology and Motility Association and Asia-Pacific Association of Gastroenterology Chronic Constipation Consensus 2026.

Background/Aims: : Chronic constipation is a common gastrointestinal (GI) disorder in Asia, characterized by heterogeneous symptom presentation, frequent overlap with other GI symptoms, and limited access to specialized diagnostic tests in many settings. These factors contribute...

Adaptable weaving origami

As intelligence continues to deepen in engineering fields, adaptable shape-morphing structures face increasing demands for multifunctionality and reconfigurability. Origami has been widely explored in deployable structures, mechanical computing, metamaterials, and metamorphic rob...

Emerging nitrogen-driven urban atmosphere control on aerosol iron dissolution for biogeochemical cycles

Iron (Fe) is a critical micronutrient regulating marine productivity and the global carbon cycle, yet its atmospheric dissolution mechanisms remain debated for biogeochemical cycle. The prevailing “iron-sulfur coupling” paradigm has traditionally explained proton-promoted dissolu...

Exploring mathematics educational values (MEV) differences in experienced mathematics teachers’ narratives of critical incidents

Abstract Teachers’ instructional decisions reflect underlying pedagogical values, yet limited research examines how teachers recognise and interpret value differences in classroom practice. This study investigates how nine experienced Malaysian secondary mathematics teachers inte...

Disintermediation Governance and Complementor Innovation: An Empirical Look at Amazon.com

This study investigates how the platform’s disintermediation governance policy (i.e., the policy that disciplines complementors and consumers circumventing the platform to transact directly) affects complementors’ product innovation and launching strategies. We leverage a change...

Rare Variants May Influence Disease Risk and Clinical Features in Sporadic Late-Onset Chinese Parkinson’s Disease Patients

BackgroundThe heritability in Parkinson’s disease (PD) may be contributed by rare variants (RVs) in candidate genes. Currently there is limited genetic data on Chinese PD patients.ObjectiveWe aim to identify RVs in Chinese PD patients and investigate their relationships with risk...

Optimised murine model of influenza-induced respiratory sepsis for studying acute kidney injury

Abstract Background Viral respiratory sepsis, driven by influenza and COVID-19, is increasingly prominent clinically. However, there is a lack of preclinical models that reliably replicate its associated acute kidney injury (AKI), a major contributor to morbidity and mortality. M...

Managing Perishable Inventory Systems with Positive Lead Times: Inventory Position vs. Projected Inventory Level

We study periodic review perishable inventory systems with a fixed product lifetime, positive replenishment lead times, and a general issuance policy under the average cost criterion. The optimal replenishment policy for such systems is notoriously complex and computationally int...

Trauma, Transience, and Traversal: Philosophizing on Time Through Su Shi’s Huangzhou-Period Literary Works

Abstract Su Shi’s literary works duing exile in Huangzhou explore temporal experience. To heal the trauma inflicted by the Crow Terrace Poetry Trial, he must understand the temporality of trauma. Trauma is a dialectic of transience. A traumatic event must involve a sudden, unfore...

Comparison and Selection of Network Meta‐Analysis Models for Fitting and Extrapolating Cancer Survival Data

ABSTRACT Aim To assess network meta‐analysis (NMA) model biases under different proportional hazards (PHs) scenarios, compare fitting and extrapolation performance for hazard ratios (HRs) using cancer survival data, identify metrics guiding model selection, and compare extrapolat...

Minimax-Optimal Reward-Agnostic Exploration in Reinforcement Learning

This paper studies reward-agnostic exploration in reinforcement learning (RL)—a scenario where the learner is unaware of the reward functions during the exploration stage—and designs an algorithm that improves over the state of the art. More precisely, consider a finite-horizon i...

Robust Public Process in Cultural Planning: Institutionalizing Participation in U.S. Cultural Plans

Problem, research strategy, and findings Cultural planning is widely framed as participatory, yet persistent gaps remain between participatory aspirations and equity-oriented planning and governance. In this study I asked: (1) What constitutes a robust public process in cultural...

Suppression of Peierls Instability in a Metal−Halide Porous Framework

ABSTRACT Peierls distortion is a lattice instability in low‐dimensional materials driven by electron–phonon coupling, which opens an energy gap at the Fermi level and induces a metal–insulator transition. Suppressing this distortion is crucial for stabilizing metallic and superco...

Contract-guarded orchestration of the UAV photogrammetry-to-engine handoff: artifact contracts, guarded language-model repair, and a fault-injection benchmark

This paper presents a reliable AI-agent framework for automating the delivery of UAV photogrammetric reconstructions into real-time engines for visualization and digital-twin applications. Conventional workflows often rely on process exit status, allowing semantic errors—such as...

Contract-guarded orchestration of the UAV photogrammetry-to-engine handoff: artifact contracts, guarded language-model repair, and a fault-injection benchmark

This paper presents a reliable AI-agent framework for automating the delivery of UAV photogrammetric reconstructions into real-time engines for visualization and digital-twin applications. Conventional workflows often rely on process exit status, allowing semantic errors—such as...