Chinese University of Hong Kong

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

ABSTRACT 3D bioprinting is known for its high precision and reproducibility in fabricating complex and customized biomedical constructs. However, its applications are limited by their static nature; i.e., unlike native tissues, they cannot change shape or functionality over time....

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

ABSTRACT Diabetic Foot Ulcer (DFU), a severe chronic diabetes complication with low healing and high recurrence rates, is a major global health challenge. Overexpression of matrix metalloproteinase‐9 (MMP‐9) and the consequent MMP‐9/TIMP1 (tissue inhibitor of metalloproteinase 1)...

Evaluation of 18 S rRNA as an endogenous control in OpenArray® plasma RNA qPCR workflows

Abstract Background Reliable qPCR analysis depends on stable endogenous controls, particularly in high-throughput pre-amplification workflows where technical bias may arise. The suitability of highly abundant 18 S rRNA as a reference gene in multiplex OpenArray ® platforms remain...

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

ABSTRACT Joint profiling of chromatin accessibility and gene expression in the same cell enables direct linkage of regulatory elements to transcriptional output, but existing approaches remain limited by low co‐capture sensitivity, proprietary platforms, and high costs. Here we p...

“I want to undergo colonoscopy, but…”: qualitative study of colonoscopy screening intentions and actions amongst first-degree relatives of patients with colorectal cancer

Abstract Background Interventions targeting intention formation and action implementation are expected to further increase colonoscopy uptake amongst the first-degree relatives (FDRs) of patients with colorectal cancer (CRC). To inform the development of precise and efficient int...

Precise Structure Control in Phase-Engineered Nanomaterials: The Case of Noble Metals

Abstract Phase-engineered noble-metal nanomaterials, distinguished by atomic arrangements distinct from those of their conventional counterparts, have emerged as promising materials with enhanced physicochemical properties for diverse applications. Despite the immense potential,...

Learning from mistakes: Objective and subjective error magnitudes predict the testing effect

Abstract The testing effect—where retrieval practice enhances memory more than restudy—remains mechanistically debated. We advance an error-driven learning (EDL) account, proposing that testing enhances memory by generating error signals that drive learning. Across two experiment...

Accentedness and Comprehensibility in Second Language Cantonese: An Investigation of Mandarin Learners’ Read Speech

Research on accentedness and comprehensibility has largely focused on nontonal target languages, leaving it unclear whether established predictors of these two constructs apply to tonal languages with complex tone systems, such as Cantonese. We investigated 40 Mandarin-speaking l...

Unpacking student interactions in GenAI ‐assisted social annotation: An epistemic network analysis of cognitive and social presence

Abstract Cognitive presence and social presence are essential for computer‐supported collaborative learning (CSCL). Yet, monitoring and providing personalised feedback to support these presences remain a persistent challenge, particularly in the context of social annotation (SA)....

On the use of a discrepancy decomposition model for calibration experiments

Computer simulation models are widely used to study complex physical systems. A related topic is the calibration problem, which aims at learning about the values of parameters in the model based on observations. In most real applications, the parameters have specific physical mea...

Association of Polyunsaturated Fatty Acids and Incident Glaucoma: The UK Biobank, Multi Omics, and Therapeutic Strategies Study

ABSTRACT Purpose To investigate the associations and causal effects of polyunsaturated fatty acids (PUFAs) with incident glaucoma and identify intervention thresholds and therapeutic strategies. Methods This prospective study included 451,199 glaucoma‐free UK Biobank participants...

Ethnic and Racial Variations in Thyroid Eye Disease: Clinical Features and Management

Background: Thyroid eye disease (TED) is an autoimmune orbital disorder with a broad clinical spectrum, ranging from mild symptoms to sight-threatening complications. Increasing evidence demonstrates variation in disease presentation and severity across populations, with implicat...

A Silk Nanofiber‐Mediated Controlled Swelling‐Locking Strategy for Tough, Anti‐Swelling Hydrogels Toward Underwater Sensing

ABSTRACT Conductive hydrogels are promising for wearable sensors in human motion detection owing to their skin‐like softness, strain sensitivity, and biocompatibility. However, their practical application in aqueous environments is severely hindered by swelling‐induced mechanical...

Association of lipid-frailty composite indices with cardiovascular disease risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: evidence from the UK Biobank and CHARLS

Non-traditional lipid indices have been increasingly investigated as predictors of cardiovascular disease (CVD) risk, and frailty reflects cumulative physiological decline. Whether integrating these complementary dimensions improves CVD risk prediction remains unexplored. We aime...

AI-assisted speaking practice for EFL learners: effects on anxiety, enjoyment, and engagement compared to traditional teacher-led practice

Abstract Although recent studies have demonstrated the potential of AI chatbots in reducing foreign language speaking anxiety (FLSA) and enhancing positive emotions, significant gaps remain in the literature. Most previous research has examined anxiety, enjoyment, and engagement...

Exploratory data analysis of tonometry and PTT/PIR signals for cuffless blood pressure monitoring: dynamic responsiveness versus baseline stability

OBJECTIVE: Sensing modalities for cuffless blood pressure (BP) monitoring remain insufficiently characterized. To address this, we used exploratory data analysis (EDA) to evaluate multimodal physiological signals' associations with reference BP, to gain insight into their BP-rela...

Stabilizing telerobotic endobronchial imaging and interventions in breathing lungs with a helical brace

Physiological motion in dynamic luminal organs, such as respiration-induced lung displacement, compromises the stability of tool-tissue interaction during telerobotic endoluminal imaging and interventions. However, existing devices for stabilizing the distal end of a catheter or...

Higher inter-rater agreement but more low-risk judgments: the influence of rater experience on RoB 2 assessments

It remains unclear whether risk-of-bias judgments made using the revised Cochrane risk-of-bias tool for randomized trials (RoB 2) by less experienced raters, even after standard training, systematically differ from those made by experienced raters. Our study recruited 12 inexperi...

Global bounded solutions of the 3D Patlak-Keller-Segel-Navier-Stokes system via Couette flow and logistic source

As is well-known, the solutions to the Patlak-Keller-Segel system in 3D may blow up in finite time regardless of any initial cell mass. In this paper, we investigate the existence of global bounded solutions of the 3D Patlak-Keller-Segel-Navier-Stokes system with a large initial...

Global Paid and Unpaid Productivity Losses Due to Gastrointestinal Cancer Mortality

OBJECTIVES: Gastrointestinal (GI) cancers contribute substantially to premature mortality, yet their full economic burden, including unpaid work, remains underquantified. We aimed to estimate global productivity losses attributable to GI cancer mortality, considering paid and unp...